Transient HES5 Activity Instructs Mesodermal Cells toward a Cardiac Fate

Transient HES5 Activity Instructs Mesodermal Cells toward a Cardiac Fate

Notch signaling plays a role in specifying a cardiac fate but the downstream effectors remain unknown. In this study we implicate the Notch downstream effector HES5 in cardiogenesis. We show transient Hes5 expression in early mesoderm of gastrulating embryos and demonstrate, by loss and gain-of-func...

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Bibliographic Details
Main Authors: Ana G. Freire, Avinash Waghray, Francisca Soares-da-Silva, Tatiana P. Resende, Dung-Fang Lee, Carlos-Filipe Pereira, Diana S. Nascimento, Ihor R. Lemischka, Perpétua Pinto-do-Ó
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Stem Cell Reports
Subjects:
Hes5
notch signaling pathway
cardiac fate specification
nascent mesoderm
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117302321

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