N-Terminal Pro-Brain Natriuretic Peptide (Nt-proBNP) Serum Concentrations in Apparently Healthy Bosnian Women
Brain natriuretic peptide (BNP) is a cardiac hormone secreted predominantly from the ventricles. This hormone is produced as pre-prohormone BNP (pro BNP), than cleaved by corine to biologically active 32-aminoacid BNP and non-biologically active N-terminal-pro brain natriuretic peptide (NTproBNP). N...
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| Format: | Article |
| Language: | English |
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Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2007-11-01
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| Series: | Biomolecules & Biomedicine |
| Subjects: | |
| Online Access: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/3018 |
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| author | Almira Hadžović-Džuvo Elma Kučukalić-Selimović Emina Nakaš-Ićindić Asija Zaćiragić Zdenka Dražeta |
| author_facet | Almira Hadžović-Džuvo Elma Kučukalić-Selimović Emina Nakaš-Ićindić Asija Zaćiragić Zdenka Dražeta |
| author_sort | Almira Hadžović-Džuvo |
| collection | DOAJ |
| description | Brain natriuretic peptide (BNP) is a cardiac hormone secreted predominantly from the ventricles. This hormone is produced as pre-prohormone BNP (pro BNP), than cleaved by corine to biologically active 32-aminoacid BNP and non-biologically active N-terminal-pro brain natriuretic peptide (NTproBNP). NTproBNP has been found to be a useful marker for the diagnosis of heart failure and left ventricular systolic dysfunction. Recent studies showed that concentration of BNP and NTproBNP predict cardiovascular disease in apparently healthy individuals but their full screening characteristics are not firmly established. As NTproBNP serum concentration is altered by numerous factors there are also interindividual variations in NTproBNP values.
There are no previous results for Bosnian population so the aim of this study was to asses normal range of NTproBNP serum concentrations in apparently healthy women using electrochemiluminescence immunoassay (Elecsys, Roche Diagnostic). A group of 45, healthy females, aged 39,19 (±6,62), were enrolled in this study. Mean serum concentration of NTproBNP was 60,32 (±36,25) pg/ml, with the range of 112,60 pg/ml (minimum-maximum:13,6-126,00 pg/ml).
We conclude that NTproBNP serum concentration in apparently healthy Bosnian women was not different from the average values of NTproBNP obtained on Europen’s population. Thus, we suggest that the NTproBNP serum upper cut off values measured by using electrochemiluminescence immunoassay “ECLIA” (Elecsys 2010, Roche Diagnostic) for Bosnian females, aged <50 years, should be 155 pg/ml as reported by Roche Diagnostic.
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| first_indexed | 2024-04-24T23:31:57Z |
| format | Article |
| id | doaj.art-eceb011a99ed49cfa5f100ae7adb01da |
| institution | Directory Open Access Journal |
| issn | 2831-0896 2831-090X |
| language | English |
| last_indexed | 2024-04-24T23:31:57Z |
| publishDate | 2007-11-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
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| series | Biomolecules & Biomedicine |
| spelling | doaj.art-eceb011a99ed49cfa5f100ae7adb01da2024-03-15T14:38:19ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2007-11-017410.17305/bjbms.2007.3018603N-Terminal Pro-Brain Natriuretic Peptide (Nt-proBNP) Serum Concentrations in Apparently Healthy Bosnian WomenAlmira Hadžović-Džuvo0Elma Kučukalić-Selimović1Emina Nakaš-Ićindić2Asija Zaćiragić3Zdenka Dražeta4Institute of Physiology and Biochemistry, Faculty of Medicine, University of SarajevoInstitute of Nuclear Medicine, University of Sarajevo Clinics CentreInstitute of Physiology and Biochemistry, Faculty of Medicine, University of SarajevoInstitute of Physiology and Biochemistry, Faculty of Medicine, University of SarajevoInstitute of Nuclear Medicine, University of Sarajevo Clinics CentreBrain natriuretic peptide (BNP) is a cardiac hormone secreted predominantly from the ventricles. This hormone is produced as pre-prohormone BNP (pro BNP), than cleaved by corine to biologically active 32-aminoacid BNP and non-biologically active N-terminal-pro brain natriuretic peptide (NTproBNP). NTproBNP has been found to be a useful marker for the diagnosis of heart failure and left ventricular systolic dysfunction. Recent studies showed that concentration of BNP and NTproBNP predict cardiovascular disease in apparently healthy individuals but their full screening characteristics are not firmly established. As NTproBNP serum concentration is altered by numerous factors there are also interindividual variations in NTproBNP values. There are no previous results for Bosnian population so the aim of this study was to asses normal range of NTproBNP serum concentrations in apparently healthy women using electrochemiluminescence immunoassay (Elecsys, Roche Diagnostic). A group of 45, healthy females, aged 39,19 (±6,62), were enrolled in this study. Mean serum concentration of NTproBNP was 60,32 (±36,25) pg/ml, with the range of 112,60 pg/ml (minimum-maximum:13,6-126,00 pg/ml). We conclude that NTproBNP serum concentration in apparently healthy Bosnian women was not different from the average values of NTproBNP obtained on Europen’s population. Thus, we suggest that the NTproBNP serum upper cut off values measured by using electrochemiluminescence immunoassay “ECLIA” (Elecsys 2010, Roche Diagnostic) for Bosnian females, aged <50 years, should be 155 pg/ml as reported by Roche Diagnostic. https://www.bjbms.org/ojs/index.php/bjbms/article/view/3018NTproBNP serum concentrationfemaleshealthy subjects |
| spellingShingle | Almira Hadžović-Džuvo Elma Kučukalić-Selimović Emina Nakaš-Ićindić Asija Zaćiragić Zdenka Dražeta N-Terminal Pro-Brain Natriuretic Peptide (Nt-proBNP) Serum Concentrations in Apparently Healthy Bosnian Women Biomolecules & Biomedicine NTproBNP serum concentration females healthy subjects |
| title | N-Terminal Pro-Brain Natriuretic Peptide (Nt-proBNP) Serum Concentrations in Apparently Healthy Bosnian Women |
| title_full | N-Terminal Pro-Brain Natriuretic Peptide (Nt-proBNP) Serum Concentrations in Apparently Healthy Bosnian Women |
| title_fullStr | N-Terminal Pro-Brain Natriuretic Peptide (Nt-proBNP) Serum Concentrations in Apparently Healthy Bosnian Women |
| title_full_unstemmed | N-Terminal Pro-Brain Natriuretic Peptide (Nt-proBNP) Serum Concentrations in Apparently Healthy Bosnian Women |
| title_short | N-Terminal Pro-Brain Natriuretic Peptide (Nt-proBNP) Serum Concentrations in Apparently Healthy Bosnian Women |
| title_sort | n terminal pro brain natriuretic peptide nt probnp serum concentrations in apparently healthy bosnian women |
| topic | NTproBNP serum concentration females healthy subjects |
| url | https://www.bjbms.org/ojs/index.php/bjbms/article/view/3018 |
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