Mechanisms of Long Non-Coding RNA in Breast Cancer
The landscape of pervasive transcription in eukaryotic genomes has made space for the identification of thousands of transcripts that are difficult to frame in a specific functional category. A new class has been broadly named as long non-coding RNAs (lncRNAs) and shortly defined as transcripts that...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/5/4538 |
| _version_ | 1797615205958549504 |
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| author | Bianca Giuliani Chiara Tordonato Francesco Nicassio |
| author_facet | Bianca Giuliani Chiara Tordonato Francesco Nicassio |
| author_sort | Bianca Giuliani |
| collection | DOAJ |
| description | The landscape of pervasive transcription in eukaryotic genomes has made space for the identification of thousands of transcripts that are difficult to frame in a specific functional category. A new class has been broadly named as long non-coding RNAs (lncRNAs) and shortly defined as transcripts that are longer than 200 nucleotides with no or limited coding potential. So far, about 19,000 lncRNAs genes have been annotated in the human genome (Gencode 41), nearly matching the number of protein-coding genes. A key scientific priority is the functional characterization of lncRNAs, a major challenge in molecular biology that has encouraged many high-throughput efforts. LncRNA studies have been stimulated by the enormous clinical potential that these molecules promise and have been based on the characterization of their expression and functional mechanisms. In this review, we illustrate some of these mechanisms as they have been pictured in the context of breast cancer. |
| first_indexed | 2024-03-11T07:23:06Z |
| format | Article |
| id | doaj.art-ecec933b372a40ffa9aba6e3dd7de8b5 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T07:23:06Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ecec933b372a40ffa9aba6e3dd7de8b52023-11-17T07:49:55ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-02-01245453810.3390/ijms24054538Mechanisms of Long Non-Coding RNA in Breast CancerBianca Giuliani0Chiara Tordonato1Francesco Nicassio2Center for Genomic Science of IIT@SEMM, Istituto Italiano di Tecnologia (IIT), 20139 Milan, ItalyIEO, European Institute of Oncology IRCCS, 20139 Milan, ItalyCenter for Genomic Science of IIT@SEMM, Istituto Italiano di Tecnologia (IIT), 20139 Milan, ItalyThe landscape of pervasive transcription in eukaryotic genomes has made space for the identification of thousands of transcripts that are difficult to frame in a specific functional category. A new class has been broadly named as long non-coding RNAs (lncRNAs) and shortly defined as transcripts that are longer than 200 nucleotides with no or limited coding potential. So far, about 19,000 lncRNAs genes have been annotated in the human genome (Gencode 41), nearly matching the number of protein-coding genes. A key scientific priority is the functional characterization of lncRNAs, a major challenge in molecular biology that has encouraged many high-throughput efforts. LncRNA studies have been stimulated by the enormous clinical potential that these molecules promise and have been based on the characterization of their expression and functional mechanisms. In this review, we illustrate some of these mechanisms as they have been pictured in the context of breast cancer.https://www.mdpi.com/1422-0067/24/5/4538LncRNAscancerbreastgene expressionMicroRNAchromatin |
| spellingShingle | Bianca Giuliani Chiara Tordonato Francesco Nicassio Mechanisms of Long Non-Coding RNA in Breast Cancer International Journal of Molecular Sciences LncRNAs cancer breast gene expression MicroRNA chromatin |
| title | Mechanisms of Long Non-Coding RNA in Breast Cancer |
| title_full | Mechanisms of Long Non-Coding RNA in Breast Cancer |
| title_fullStr | Mechanisms of Long Non-Coding RNA in Breast Cancer |
| title_full_unstemmed | Mechanisms of Long Non-Coding RNA in Breast Cancer |
| title_short | Mechanisms of Long Non-Coding RNA in Breast Cancer |
| title_sort | mechanisms of long non coding rna in breast cancer |
| topic | LncRNAs cancer breast gene expression MicroRNA chromatin |
| url | https://www.mdpi.com/1422-0067/24/5/4538 |
| work_keys_str_mv | AT biancagiuliani mechanismsoflongnoncodingrnainbreastcancer AT chiaratordonato mechanismsoflongnoncodingrnainbreastcancer AT francesconicassio mechanismsoflongnoncodingrnainbreastcancer |