Microbial-Derived Uremic Toxins: Role in the Pathogenesis of Comorbidities in Patients with Chronic Kidney Disease
Аim: to analyze the significance of microbial-derived uremic toxins (MDUT) in the pathogenesis of comorbidities in patients with chronic kidney disease (CKD).Key findings. Increased excretion of nitrogen metabolism products into the intestines of patients with CKD is associated with uremic dysbiosis...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2023-09-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| Subjects: | |
| Online Access: | https://www.gastro-j.ru/jour/article/view/895 |
| _version_ | 1797245159696498688 |
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| author | M. O. Pyatchenkov A. A. Vlasov E. V. Sherbakov S. P. Salikova |
| author_facet | M. O. Pyatchenkov A. A. Vlasov E. V. Sherbakov S. P. Salikova |
| author_sort | M. O. Pyatchenkov |
| collection | DOAJ |
| description | Аim: to analyze the significance of microbial-derived uremic toxins (MDUT) in the pathogenesis of comorbidities in patients with chronic kidney disease (CKD).Key findings. Increased excretion of nitrogen metabolism products into the intestines of patients with CKD is associated with uremic dysbiosis; changes in the metabolic activity of the gut microbiota and the leaky gut syndrome; which largely cause the accumulation of MDUT in the internal environment of the body: indoxyl sulfate; p-cresyl sulfate; trimethylamine-N-oxide; etc. The results of recent studies allow to consider these metabolites as an independent risk factor for adverse outcomes in people with CKD due to the progression of renal dysfunction to the terminal stage; as well as frequent cardiovascular; neurological; bone mineral; nutritional and other complications.Conclusion. MDUT are one of the key modulators of the pathogenetic relationship between the gut and kidneys. Therapeutic manipulations with intestinal microbiota can be considered a promising strategy for preventing complications associated with uremia. |
| first_indexed | 2024-03-08T09:21:30Z |
| format | Article |
| id | doaj.art-ececbd4d510f4f39a441f8c7079ff7da |
| institution | Directory Open Access Journal |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| last_indexed | 2024-04-24T19:22:29Z |
| publishDate | 2023-09-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj.art-ececbd4d510f4f39a441f8c7079ff7da2024-03-25T16:53:10ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732023-09-0133371510.22416/1382-4376-2023-33-3-7-15554Microbial-Derived Uremic Toxins: Role in the Pathogenesis of Comorbidities in Patients with Chronic Kidney DiseaseM. O. Pyatchenkov0A. A. Vlasov1E. V. Sherbakov2S. P. Salikova3Kirov Military Medical AcademyKirov Military Medical AcademyKirov Military Medical AcademyKirov Military Medical AcademyАim: to analyze the significance of microbial-derived uremic toxins (MDUT) in the pathogenesis of comorbidities in patients with chronic kidney disease (CKD).Key findings. Increased excretion of nitrogen metabolism products into the intestines of patients with CKD is associated with uremic dysbiosis; changes in the metabolic activity of the gut microbiota and the leaky gut syndrome; which largely cause the accumulation of MDUT in the internal environment of the body: indoxyl sulfate; p-cresyl sulfate; trimethylamine-N-oxide; etc. The results of recent studies allow to consider these metabolites as an independent risk factor for adverse outcomes in people with CKD due to the progression of renal dysfunction to the terminal stage; as well as frequent cardiovascular; neurological; bone mineral; nutritional and other complications.Conclusion. MDUT are one of the key modulators of the pathogenetic relationship between the gut and kidneys. Therapeutic manipulations with intestinal microbiota can be considered a promising strategy for preventing complications associated with uremia.https://www.gastro-j.ru/jour/article/view/895uremic toxinsgut microbiotachronic kidney diseasecomorbidities |
| spellingShingle | M. O. Pyatchenkov A. A. Vlasov E. V. Sherbakov S. P. Salikova Microbial-Derived Uremic Toxins: Role in the Pathogenesis of Comorbidities in Patients with Chronic Kidney Disease Российский журнал гастроэнтерологии, гепатологии, колопроктологии uremic toxins gut microbiota chronic kidney disease comorbidities |
| title | Microbial-Derived Uremic Toxins: Role in the Pathogenesis of Comorbidities in Patients with Chronic Kidney Disease |
| title_full | Microbial-Derived Uremic Toxins: Role in the Pathogenesis of Comorbidities in Patients with Chronic Kidney Disease |
| title_fullStr | Microbial-Derived Uremic Toxins: Role in the Pathogenesis of Comorbidities in Patients with Chronic Kidney Disease |
| title_full_unstemmed | Microbial-Derived Uremic Toxins: Role in the Pathogenesis of Comorbidities in Patients with Chronic Kidney Disease |
| title_short | Microbial-Derived Uremic Toxins: Role in the Pathogenesis of Comorbidities in Patients with Chronic Kidney Disease |
| title_sort | microbial derived uremic toxins role in the pathogenesis of comorbidities in patients with chronic kidney disease |
| topic | uremic toxins gut microbiota chronic kidney disease comorbidities |
| url | https://www.gastro-j.ru/jour/article/view/895 |
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