The Effects of Olive Leaf Extract Administration on the Cerebral Hypoperfusion-Induced Electrophysiological Alterations in Rat Heart
Background and Aim: In the present study, the role of ethanolic extract of olive (Olea europaea) leaf administration against the cerebral hypoperfusion-induced electrophysiological alterations and left ventricular thickness in rat heart was studied. Materials and Methods: The right carotid artery w...
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| Format: | Article |
| Language: | English |
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Lorestan University of Medical Sciences
2017-12-01
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| Series: | Herbal Medicines Journal |
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| Online Access: | http://hmj.lums.ac.ir/index.php/hmj/article/view/624 |
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| author | Mehrnoush Moghaddasi Majid Taati Hasan Noroozi Sam Bamani Lirgeshasi Soheila Pourkhodadad Bahram Delfan Afshin Nazari * |
| author_facet | Mehrnoush Moghaddasi Majid Taati Hasan Noroozi Sam Bamani Lirgeshasi Soheila Pourkhodadad Bahram Delfan Afshin Nazari * |
| author_sort | Mehrnoush Moghaddasi |
| collection | DOAJ |
| description | Background and Aim: In the present study, the role of ethanolic extract of olive (Olea europaea) leaf administration against the cerebral hypoperfusion-induced electrophysiological alterations and left ventricular thickness in rat heart was studied.
Materials and Methods: The right carotid artery was occluded with a 5-0 silk suture and the left carotid artery was occluded after a week. The olive (Olea europaea) leaf extract was administered orally (by gavage) to three experimental groups of rats in 100, 200 and 300 mg/kg/day for two weeks after the left carotid artery occlusion and processed in 25 days. The sham and hypoperfusion groups were fed with normal saline. Each group had 6 rats. After 25 days, electrophysiological heart parameters, i.e. HR, QTc, QRS duration, QT interval, PR interval, RR interval, ST amplitude, T wave amplitude and also the thickness of left ventricle (TLV) were assessed.
Results: The administration of olive leaf extract (100, 200 and 300 mg/kg) exhibited its cardioprotective effect by both stabilizing heart rate and preventing ECG changes (such as shortening of PR, QRS, QT and QTc intervals, prominent T waves and ST elevation). Moreover, olive leaf extract (100, 200 and 300 mg/kg) prevented cardiac hypertrophy after cerebral hypoperfusion.
Conclusion: Our results indicated that post-treatment with ethanolic extract of olive leaves could prove beneficial effects in managing the cerebral hypoperfusion-induced cardiac abnormality in rats. |
| first_indexed | 2024-12-13T12:15:07Z |
| format | Article |
| id | doaj.art-ecf320d386744f1884eda38d2d97183f |
| institution | Directory Open Access Journal |
| issn | 2538-2144 2538-2144 |
| language | English |
| last_indexed | 2024-12-13T12:15:07Z |
| publishDate | 2017-12-01 |
| publisher | Lorestan University of Medical Sciences |
| record_format | Article |
| series | Herbal Medicines Journal |
| spelling | doaj.art-ecf320d386744f1884eda38d2d97183f2022-12-21T23:46:45ZengLorestan University of Medical SciencesHerbal Medicines Journal2538-21442538-21442017-12-010010.22087/hmj.v0i0.624525The Effects of Olive Leaf Extract Administration on the Cerebral Hypoperfusion-Induced Electrophysiological Alterations in Rat HeartMehrnoush MoghaddasiMajid TaatiHasan NorooziSam Bamani LirgeshasiSoheila PourkhodadadBahram DelfanAfshin Nazari *Background and Aim: In the present study, the role of ethanolic extract of olive (Olea europaea) leaf administration against the cerebral hypoperfusion-induced electrophysiological alterations and left ventricular thickness in rat heart was studied. Materials and Methods: The right carotid artery was occluded with a 5-0 silk suture and the left carotid artery was occluded after a week. The olive (Olea europaea) leaf extract was administered orally (by gavage) to three experimental groups of rats in 100, 200 and 300 mg/kg/day for two weeks after the left carotid artery occlusion and processed in 25 days. The sham and hypoperfusion groups were fed with normal saline. Each group had 6 rats. After 25 days, electrophysiological heart parameters, i.e. HR, QTc, QRS duration, QT interval, PR interval, RR interval, ST amplitude, T wave amplitude and also the thickness of left ventricle (TLV) were assessed. Results: The administration of olive leaf extract (100, 200 and 300 mg/kg) exhibited its cardioprotective effect by both stabilizing heart rate and preventing ECG changes (such as shortening of PR, QRS, QT and QTc intervals, prominent T waves and ST elevation). Moreover, olive leaf extract (100, 200 and 300 mg/kg) prevented cardiac hypertrophy after cerebral hypoperfusion. Conclusion: Our results indicated that post-treatment with ethanolic extract of olive leaves could prove beneficial effects in managing the cerebral hypoperfusion-induced cardiac abnormality in rats.http://hmj.lums.ac.ir/index.php/hmj/article/view/624Electrocardiogram, Cerebral hypoperfusion, Left ventricle, Olive leaf extract |
| spellingShingle | Mehrnoush Moghaddasi Majid Taati Hasan Noroozi Sam Bamani Lirgeshasi Soheila Pourkhodadad Bahram Delfan Afshin Nazari * The Effects of Olive Leaf Extract Administration on the Cerebral Hypoperfusion-Induced Electrophysiological Alterations in Rat Heart Herbal Medicines Journal Electrocardiogram, Cerebral hypoperfusion, Left ventricle, Olive leaf extract |
| title | The Effects of Olive Leaf Extract Administration on the Cerebral Hypoperfusion-Induced Electrophysiological Alterations in Rat Heart |
| title_full | The Effects of Olive Leaf Extract Administration on the Cerebral Hypoperfusion-Induced Electrophysiological Alterations in Rat Heart |
| title_fullStr | The Effects of Olive Leaf Extract Administration on the Cerebral Hypoperfusion-Induced Electrophysiological Alterations in Rat Heart |
| title_full_unstemmed | The Effects of Olive Leaf Extract Administration on the Cerebral Hypoperfusion-Induced Electrophysiological Alterations in Rat Heart |
| title_short | The Effects of Olive Leaf Extract Administration on the Cerebral Hypoperfusion-Induced Electrophysiological Alterations in Rat Heart |
| title_sort | effects of olive leaf extract administration on the cerebral hypoperfusion induced electrophysiological alterations in rat heart |
| topic | Electrocardiogram, Cerebral hypoperfusion, Left ventricle, Olive leaf extract |
| url | http://hmj.lums.ac.ir/index.php/hmj/article/view/624 |
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