Effect of Carbohydrate-Restricted Dietary Pattern on Insulin Treatment Rate, Lipid Metabolism and Nutritional Status in Pregnant Women with Gestational Diabetes in Beijing, China
Carbohydrates play an important role in blood glucose control in pregnant women with GDM. Carbohydrate-restricted dietary (CRD) pattern for gestational diabetes mellitus (GDM) has been widely used in clinics, but the change in insulin utilization rate beyond CRD intervention in GDM remains unclear....
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MDPI AG
2022-01-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/2/359 |
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| author | Mingxuan Cui Xuening Li Chen Yang Linlin Wang Lulu Lu Shilong Zhao Qianying Guo Peng Liu |
| author_facet | Mingxuan Cui Xuening Li Chen Yang Linlin Wang Lulu Lu Shilong Zhao Qianying Guo Peng Liu |
| author_sort | Mingxuan Cui |
| collection | DOAJ |
| description | Carbohydrates play an important role in blood glucose control in pregnant women with GDM. Carbohydrate-restricted dietary (CRD) pattern for gestational diabetes mellitus (GDM) has been widely used in clinics, but the change in insulin utilization rate beyond CRD intervention in GDM remains unclear. The aim of the present study was to explore the application of insulin in pregnancy with GDM, as well as the influence of CRD pattern on lipid metabolism and nutritional state. A retrospective study of 265 women with GDM who delivered in Peking University People’s Hospital from July 2018 to January 2020 was conducted using a questionnaire survey. Women were divided into a CRD group or a control group according to whether they had received CRD intervention during pregnancy. There was no statistically significant difference in the rate of insulin therapy between the two groups (<i>p</i> > 0.05), the initial gestational week of the CRD group combined with insulin treatment was significantly higher than that of the control group (<i>p</i> < 0.05), and the risk of insulin therapy was positively correlated with fasting plasma glucose (FPG) in early pregnancy (<i>p</i> < 0.05). The incidence of abnormal low-density lipoprotein cholesterol levels in the CRD group was significantly lower than that in the control group (<i>p</i> < 0.05). There were no significant differences in nutritional indexes between the two groups. The results indicate that CRD intervention may be effective in delaying the use of insulin and improving the blood lipids metabolism during GDM pregnancy, while nutritional status may not be significantly affected under CRD intervention, and a high FPG in early pregnancy with GDM may be a risk factor for combined insulin therapy with CRD intervention. |
| first_indexed | 2024-03-10T00:47:34Z |
| format | Article |
| id | doaj.art-ecf37ec668e743bea42b985948677329 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T00:47:34Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-ecf37ec668e743bea42b9859486773292023-11-23T14:58:10ZengMDPI AGNutrients2072-66432022-01-0114235910.3390/nu14020359Effect of Carbohydrate-Restricted Dietary Pattern on Insulin Treatment Rate, Lipid Metabolism and Nutritional Status in Pregnant Women with Gestational Diabetes in Beijing, ChinaMingxuan Cui0Xuening Li1Chen Yang2Linlin Wang3Lulu Lu4Shilong Zhao5Qianying Guo6Peng Liu7Department of Clinical Nutrition, Peking University People’s Hospital, Beijing 100044, ChinaDepartment of Clinical Nutrition, Peking University People’s Hospital, Beijing 100044, ChinaInstitute of Reproductive and Child Health, National Health Commission Key Laboratory of Reproductive Health, School of Public Health, Peking University, Beijing 100191, ChinaInstitute of Reproductive and Child Health, National Health Commission Key Laboratory of Reproductive Health, School of Public Health, Peking University, Beijing 100191, ChinaDepartment of Clinical Nutrition, Peking University People’s Hospital, Beijing 100044, ChinaDepartment of Clinical Nutrition, Peking University People’s Hospital, Beijing 100044, ChinaDepartment of Clinical Nutrition, Peking University People’s Hospital, Beijing 100044, ChinaDepartment of Clinical Nutrition, Peking University People’s Hospital, Beijing 100044, ChinaCarbohydrates play an important role in blood glucose control in pregnant women with GDM. Carbohydrate-restricted dietary (CRD) pattern for gestational diabetes mellitus (GDM) has been widely used in clinics, but the change in insulin utilization rate beyond CRD intervention in GDM remains unclear. The aim of the present study was to explore the application of insulin in pregnancy with GDM, as well as the influence of CRD pattern on lipid metabolism and nutritional state. A retrospective study of 265 women with GDM who delivered in Peking University People’s Hospital from July 2018 to January 2020 was conducted using a questionnaire survey. Women were divided into a CRD group or a control group according to whether they had received CRD intervention during pregnancy. There was no statistically significant difference in the rate of insulin therapy between the two groups (<i>p</i> > 0.05), the initial gestational week of the CRD group combined with insulin treatment was significantly higher than that of the control group (<i>p</i> < 0.05), and the risk of insulin therapy was positively correlated with fasting plasma glucose (FPG) in early pregnancy (<i>p</i> < 0.05). The incidence of abnormal low-density lipoprotein cholesterol levels in the CRD group was significantly lower than that in the control group (<i>p</i> < 0.05). There were no significant differences in nutritional indexes between the two groups. The results indicate that CRD intervention may be effective in delaying the use of insulin and improving the blood lipids metabolism during GDM pregnancy, while nutritional status may not be significantly affected under CRD intervention, and a high FPG in early pregnancy with GDM may be a risk factor for combined insulin therapy with CRD intervention.https://www.mdpi.com/2072-6643/14/2/359carbohydrate-restricted dietary patterngestational diabetes mellitusinsulin treatment ratelipid metabolismnutritional status |
| spellingShingle | Mingxuan Cui Xuening Li Chen Yang Linlin Wang Lulu Lu Shilong Zhao Qianying Guo Peng Liu Effect of Carbohydrate-Restricted Dietary Pattern on Insulin Treatment Rate, Lipid Metabolism and Nutritional Status in Pregnant Women with Gestational Diabetes in Beijing, China Nutrients carbohydrate-restricted dietary pattern gestational diabetes mellitus insulin treatment rate lipid metabolism nutritional status |
| title | Effect of Carbohydrate-Restricted Dietary Pattern on Insulin Treatment Rate, Lipid Metabolism and Nutritional Status in Pregnant Women with Gestational Diabetes in Beijing, China |
| title_full | Effect of Carbohydrate-Restricted Dietary Pattern on Insulin Treatment Rate, Lipid Metabolism and Nutritional Status in Pregnant Women with Gestational Diabetes in Beijing, China |
| title_fullStr | Effect of Carbohydrate-Restricted Dietary Pattern on Insulin Treatment Rate, Lipid Metabolism and Nutritional Status in Pregnant Women with Gestational Diabetes in Beijing, China |
| title_full_unstemmed | Effect of Carbohydrate-Restricted Dietary Pattern on Insulin Treatment Rate, Lipid Metabolism and Nutritional Status in Pregnant Women with Gestational Diabetes in Beijing, China |
| title_short | Effect of Carbohydrate-Restricted Dietary Pattern on Insulin Treatment Rate, Lipid Metabolism and Nutritional Status in Pregnant Women with Gestational Diabetes in Beijing, China |
| title_sort | effect of carbohydrate restricted dietary pattern on insulin treatment rate lipid metabolism and nutritional status in pregnant women with gestational diabetes in beijing china |
| topic | carbohydrate-restricted dietary pattern gestational diabetes mellitus insulin treatment rate lipid metabolism nutritional status |
| url | https://www.mdpi.com/2072-6643/14/2/359 |
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