Perioperative treatment in resectable gastric cancer with spartalizumab in combination with fluorouracil, leucovorin, oxaliplatin and docetaxel (FLOT): a phase II study (GASPAR)

Perioperative treatment in resectable gastric cancer with spartalizumab in combination with fluorouracil, leucovorin, oxaliplatin and docetaxel (FLOT): a phase II study (GASPAR)

Abstract Background Perioperative chemotherapy and surgery are a standard of care for patients with resectable gastric or gastroesophageal junction (GEJ) adenocarcinoma. However, the prognosis remains poor for this population. The FLOT (fluorouracil, leucovorin, oxaliplatin, and docetaxel) regimen i...

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Main Authors: Mélanie Dos Santos, Justine Lequesne, Alexandra Leconte, Stéphane Corbinais, Aurélie Parzy, Jean-Marc Guilloit, Sharmini Varatharajah, Pierre-Emmanuel Brachet, Marine Dorbeau, Dominique Vaur, Louis-Bastien Weiswald, Laurent Poulain, Corentin Le Gallic, Marie Castera-Tellier, Marie-Pierre Galais, Bénédicte Clarisse
Format: Article
Language:English
Published: BMC 2022-05-01
Series:BMC Cancer
Subjects:
Gastric cancer
Gastroesophageal junction cancer
Neoadjuvant treatment
Immunotherapy
Spartalizumab
Online Access:https://doi.org/10.1186/s12885-022-09623-z

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