Phenanthrene Antibiotic Targets Bacterial Membranes and Kills Staphylococcus aureus With a Low Propensity for Resistance Development

Phenanthrene Antibiotic Targets Bacterial Membranes and Kills Staphylococcus aureus With a Low Propensity for Resistance Development

New classes of antibiotics with different mechanisms of action are urgently required for combating antimicrobial resistance. Blestriacin, a dihydro-biphenanthrene with significant antibacterial activity, was recently isolated from the fibrous roots of Bletilla striata. Here, we report the further ch...

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Bibliographic Details
Main Authors: Bo-Chen Chen, Chang-Xin Lin, Ni-Pi Chen, Cheng-Xian Gao, Ying-Jie Zhao, Chao-Dong Qian
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Microbiology
Subjects:
dihydro-biphenanthrene
natural product
antibiotic
mode of action
bactericidal effect
membrane-damaging activity
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.01593/full

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