Neuroanatomical, neurochemical, and neurodevelopmental basis of obsessive-Compulsive symptoms in schizophrenia
The prevalence of the obsessive-compulsive symptoms in schizophrenia (OCSS) appears to be higher than that expected on the basis of comorbidity rates. Review of brain abnormalities in schizophrenia and obsessive-compulsive disorder (OCD) reveals involvement of similar regions namely the frontal lobe...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2009-01-01
|
| Series: | Indian Journal of Psychological Medicine |
| Subjects: | |
| Online Access: | http://www.ijpm.info/article.asp?issn=0253-7176;year=2009;volume=31;issue=1;spage=3;epage=10;aulast=Venkatasubramanian |
| _version_ | 1818611694541209600 |
|---|---|
| author | Venkatasubramanian Ganesan Rao Naren Behere Rishikesh |
| author_facet | Venkatasubramanian Ganesan Rao Naren Behere Rishikesh |
| author_sort | Venkatasubramanian Ganesan |
| collection | DOAJ |
| description | The prevalence of the obsessive-compulsive symptoms in schizophrenia (OCSS) appears to be higher than that expected on the basis of comorbidity rates. Review of brain abnormalities in schizophrenia and obsessive-compulsive disorder (OCD) reveals involvement of similar regions namely the frontal lobe, the basal ganglia, the thalamus, and the cerebellum, in both the disorders. Neurodevelopmental etiopathogenesis has been proposed to explain schizophrenia as well as OCD. Significant overlap in neurotransmitter dysfunction (serotonin, glutamate, and dopamine) has been documented between schizophrenia and OCD. The New-onset obsessive-compulsive (OC) symptoms have been reported with the use of atypical antipsychotics in the schizophrenia patients In this background, OCSS is an emerging area of recent interests. This article attempts to review the literature on the neurobiology of OCSS. Neuroimaging, neuropsychological, and neuromotor abnormalities in OCSS discussed in the context of neurodevelopmental etiopathogenesis suggest glutamate abnormalities in OCSS. Atypical antipsychotic induced OCSS points towards the possible roles of glutamate and serotonin. Dopamine may be responsible for the beneficial role of antipsychotics in the treatment of OCD. In summary, we propose that glutamate, serotonin, and dopamine abnormalities may be the probable basis for OCSS. |
| first_indexed | 2024-12-16T15:34:24Z |
| format | Article |
| id | doaj.art-ecf95e2f9cee4962ab0096d318e29eb6 |
| institution | Directory Open Access Journal |
| issn | 0253-7176 |
| language | English |
| last_indexed | 2024-12-16T15:34:24Z |
| publishDate | 2009-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Indian Journal of Psychological Medicine |
| spelling | doaj.art-ecf95e2f9cee4962ab0096d318e29eb62022-12-21T22:26:15ZengSAGE PublishingIndian Journal of Psychological Medicine0253-71762009-01-01311310Neuroanatomical, neurochemical, and neurodevelopmental basis of obsessive-Compulsive symptoms in schizophreniaVenkatasubramanian GanesanRao NarenBehere RishikeshThe prevalence of the obsessive-compulsive symptoms in schizophrenia (OCSS) appears to be higher than that expected on the basis of comorbidity rates. Review of brain abnormalities in schizophrenia and obsessive-compulsive disorder (OCD) reveals involvement of similar regions namely the frontal lobe, the basal ganglia, the thalamus, and the cerebellum, in both the disorders. Neurodevelopmental etiopathogenesis has been proposed to explain schizophrenia as well as OCD. Significant overlap in neurotransmitter dysfunction (serotonin, glutamate, and dopamine) has been documented between schizophrenia and OCD. The New-onset obsessive-compulsive (OC) symptoms have been reported with the use of atypical antipsychotics in the schizophrenia patients In this background, OCSS is an emerging area of recent interests. This article attempts to review the literature on the neurobiology of OCSS. Neuroimaging, neuropsychological, and neuromotor abnormalities in OCSS discussed in the context of neurodevelopmental etiopathogenesis suggest glutamate abnormalities in OCSS. Atypical antipsychotic induced OCSS points towards the possible roles of glutamate and serotonin. Dopamine may be responsible for the beneficial role of antipsychotics in the treatment of OCD. In summary, we propose that glutamate, serotonin, and dopamine abnormalities may be the probable basis for OCSS.http://www.ijpm.info/article.asp?issn=0253-7176;year=2009;volume=31;issue=1;spage=3;epage=10;aulast=VenkatasubramanianSchizophreniaobsessive-compulsive symptomsneurodevelopment |
| spellingShingle | Venkatasubramanian Ganesan Rao Naren Behere Rishikesh Neuroanatomical, neurochemical, and neurodevelopmental basis of obsessive-Compulsive symptoms in schizophrenia Indian Journal of Psychological Medicine Schizophrenia obsessive-compulsive symptoms neurodevelopment |
| title | Neuroanatomical, neurochemical, and neurodevelopmental basis of obsessive-Compulsive symptoms in schizophrenia |
| title_full | Neuroanatomical, neurochemical, and neurodevelopmental basis of obsessive-Compulsive symptoms in schizophrenia |
| title_fullStr | Neuroanatomical, neurochemical, and neurodevelopmental basis of obsessive-Compulsive symptoms in schizophrenia |
| title_full_unstemmed | Neuroanatomical, neurochemical, and neurodevelopmental basis of obsessive-Compulsive symptoms in schizophrenia |
| title_short | Neuroanatomical, neurochemical, and neurodevelopmental basis of obsessive-Compulsive symptoms in schizophrenia |
| title_sort | neuroanatomical neurochemical and neurodevelopmental basis of obsessive compulsive symptoms in schizophrenia |
| topic | Schizophrenia obsessive-compulsive symptoms neurodevelopment |
| url | http://www.ijpm.info/article.asp?issn=0253-7176;year=2009;volume=31;issue=1;spage=3;epage=10;aulast=Venkatasubramanian |
| work_keys_str_mv | AT venkatasubramanianganesan neuroanatomicalneurochemicalandneurodevelopmentalbasisofobsessivecompulsivesymptomsinschizophrenia AT raonaren neuroanatomicalneurochemicalandneurodevelopmentalbasisofobsessivecompulsivesymptomsinschizophrenia AT behererishikesh neuroanatomicalneurochemicalandneurodevelopmentalbasisofobsessivecompulsivesymptomsinschizophrenia |