Understanding the effects of nutrition and post-exercise nutrition on skeletal muscle protein turnover: Insights from stable isotope studies
Summary: Skeletal muscle is the largest organ of the human body and plays a pivotal role in whole-body homeostasis through the maintenance of physical and metabolic health. Establishing strategies aimed at increasing the amount, and minimising loss, of muscle mass are of upmost importance. Muscle ma...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-04-01
|
| Series: | Clinical Nutrition Open Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667268521000127 |
| _version_ | 1818934955456069632 |
|---|---|
| author | Sophie Joanisse James McKendry Changhyun Lim Everson A. Nunes Tanner Stokes Jonathan C. Mcleod Stuart M. Phillips |
| author_facet | Sophie Joanisse James McKendry Changhyun Lim Everson A. Nunes Tanner Stokes Jonathan C. Mcleod Stuart M. Phillips |
| author_sort | Sophie Joanisse |
| collection | DOAJ |
| description | Summary: Skeletal muscle is the largest organ of the human body and plays a pivotal role in whole-body homeostasis through the maintenance of physical and metabolic health. Establishing strategies aimed at increasing the amount, and minimising loss, of muscle mass are of upmost importance. Muscle mass is primarily dictated by the meal-to-meal fluctuations in muscle protein synthesis (MPS) and muscle protein breakdown (MPB), each of which can be quantified through the use of stable isotopically labelled tracers. Importantly, both MPS and MPB can be influenced by external factors such as nutritional manipulation, specifically protein ingestion, and changes in loading via exercise. To date, research involving stable isotopic tracers has focused on determining the optimal dose, timing surrounding bouts of exercise, distribution and composition of protein to maximally stimulate MPS and inhibit MPB, both at rest and following exercise. In this review we focus on the use of these stable isotopically-labeled tracers to unravel the intricacies of skeletal muscle protein turnover in response to specific nutritional interventions. |
| first_indexed | 2024-12-20T05:12:30Z |
| format | Article |
| id | doaj.art-ecf9d52dba444555a5eaca052ec7391d |
| institution | Directory Open Access Journal |
| issn | 2667-2685 |
| language | English |
| last_indexed | 2024-12-20T05:12:30Z |
| publishDate | 2021-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical Nutrition Open Science |
| spelling | doaj.art-ecf9d52dba444555a5eaca052ec7391d2022-12-21T19:52:14ZengElsevierClinical Nutrition Open Science2667-26852021-04-01365677Understanding the effects of nutrition and post-exercise nutrition on skeletal muscle protein turnover: Insights from stable isotope studiesSophie Joanisse0James McKendry1Changhyun Lim2Everson A. Nunes3Tanner Stokes4Jonathan C. Mcleod5Stuart M. Phillips6Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, CanadaExercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, CanadaExercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, CanadaExercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, CanadaExercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, CanadaExercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, CanadaCorresponding author. Department of Kinesiology, McMaster University, 1280 Main St. West, Hamilton, Ontario, L8S 4K1, Canada. Tel.: +905 525 9140x24465; Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, CanadaSummary: Skeletal muscle is the largest organ of the human body and plays a pivotal role in whole-body homeostasis through the maintenance of physical and metabolic health. Establishing strategies aimed at increasing the amount, and minimising loss, of muscle mass are of upmost importance. Muscle mass is primarily dictated by the meal-to-meal fluctuations in muscle protein synthesis (MPS) and muscle protein breakdown (MPB), each of which can be quantified through the use of stable isotopically labelled tracers. Importantly, both MPS and MPB can be influenced by external factors such as nutritional manipulation, specifically protein ingestion, and changes in loading via exercise. To date, research involving stable isotopic tracers has focused on determining the optimal dose, timing surrounding bouts of exercise, distribution and composition of protein to maximally stimulate MPS and inhibit MPB, both at rest and following exercise. In this review we focus on the use of these stable isotopically-labeled tracers to unravel the intricacies of skeletal muscle protein turnover in response to specific nutritional interventions.http://www.sciencedirect.com/science/article/pii/S2667268521000127TracersSkeletal muscleProteinResistance exerciseMetabolism |
| spellingShingle | Sophie Joanisse James McKendry Changhyun Lim Everson A. Nunes Tanner Stokes Jonathan C. Mcleod Stuart M. Phillips Understanding the effects of nutrition and post-exercise nutrition on skeletal muscle protein turnover: Insights from stable isotope studies Clinical Nutrition Open Science Tracers Skeletal muscle Protein Resistance exercise Metabolism |
| title | Understanding the effects of nutrition and post-exercise nutrition on skeletal muscle protein turnover: Insights from stable isotope studies |
| title_full | Understanding the effects of nutrition and post-exercise nutrition on skeletal muscle protein turnover: Insights from stable isotope studies |
| title_fullStr | Understanding the effects of nutrition and post-exercise nutrition on skeletal muscle protein turnover: Insights from stable isotope studies |
| title_full_unstemmed | Understanding the effects of nutrition and post-exercise nutrition on skeletal muscle protein turnover: Insights from stable isotope studies |
| title_short | Understanding the effects of nutrition and post-exercise nutrition on skeletal muscle protein turnover: Insights from stable isotope studies |
| title_sort | understanding the effects of nutrition and post exercise nutrition on skeletal muscle protein turnover insights from stable isotope studies |
| topic | Tracers Skeletal muscle Protein Resistance exercise Metabolism |
| url | http://www.sciencedirect.com/science/article/pii/S2667268521000127 |
| work_keys_str_mv | AT sophiejoanisse understandingtheeffectsofnutritionandpostexercisenutritiononskeletalmuscleproteinturnoverinsightsfromstableisotopestudies AT jamesmckendry understandingtheeffectsofnutritionandpostexercisenutritiononskeletalmuscleproteinturnoverinsightsfromstableisotopestudies AT changhyunlim understandingtheeffectsofnutritionandpostexercisenutritiononskeletalmuscleproteinturnoverinsightsfromstableisotopestudies AT eversonanunes understandingtheeffectsofnutritionandpostexercisenutritiononskeletalmuscleproteinturnoverinsightsfromstableisotopestudies AT tannerstokes understandingtheeffectsofnutritionandpostexercisenutritiononskeletalmuscleproteinturnoverinsightsfromstableisotopestudies AT jonathancmcleod understandingtheeffectsofnutritionandpostexercisenutritiononskeletalmuscleproteinturnoverinsightsfromstableisotopestudies AT stuartmphillips understandingtheeffectsofnutritionandpostexercisenutritiononskeletalmuscleproteinturnoverinsightsfromstableisotopestudies |