Characterising Alzheimer's disease through integrative NMR- and LC-MS-based metabolomics

Characterising Alzheimer's disease through integrative NMR- and LC-MS-based metabolomics

Background: Alzheimer's Disease (AD) is a complex and multifactorial disease and novel approaches are needed to illuminate the underlying pathology. Metabolites comprise the end-product of genes, transcripts, and protein regulations and might reflect disease pathogenesis. Blood is a common biof...

Full description

Bibliographic Details
Main Authors:	Jonas Ellegaard Nielsen, Raluca Georgiana Maltesen, Jesper F. Havelund, Nils J. Færgeman, Charlotte Held Gotfredsen, Karsten Vestergård, Søren Risom Kristensen, Shona Pedersen
Format:	Article
Language:	English
Published:	Elsevier 2021-12-01
Series:	Metabolism Open
Subjects:	Alzheimer Metabolites Blood Extracellular vesicles Mass spectrometry Nuclear magnetic resonance
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589936821000499

Similar Items

Shotgun-based proteomics of extracellular vesicles in Alzheimer’s disease reveals biomarkers involved in immunological and coagulation pathways
by: Jonas Ellegaard Nielsen, et al.
Published: (2021-09-01)

Novel Blood-Derived Extracellular Vesicle-Based Biomarkers in Alzheimer’s Disease Identified by Proximity Extension Assay
by: Jonas Ellegaard Nielsen, et al.
Published: (2020-07-01)

Serum NMR-Based Metabolomics Profiling Identifies Lipoprotein Subfraction Variables and Amino Acid Reshuffling in Myeloma Development and Progression
by: Shona Pedersen, et al.
Published: (2023-07-01)

Reply to a letter from Jackson J et al: Effect of pH on thrombin activity measured by calibrated automated thrombinography
by: Søren Risom Kristensen, et al.
Published: (2020-08-01)

Thrombin generation measured on ST Genesia, a new platform in the coagulation routine lab: Assessment of analytical and between‐subject variation
by: Søren Risom Kristensen, et al.
Published: (2022-01-01)

The effect of pH on thrombin generation–An unrecognized potential source of variation
by: Søren Risom Kristensen, et al.
Published: (2020-02-01)

Investigation of procoagulant activity in extracellular vesicles isolated by differential ultracentrifugation
by: Thøger Nielsen, et al.
Published: (2018-12-01)

Increased activity of procoagulant factors in patients with small cell lung cancer.
by: Shona Pedersen, et al.
Published: (2021-01-01)

Extracellular vesicle-associated procoagulant phospholipid and tissue factor activity in multiple myeloma.
by: Thøger Nielsen, et al.
Published: (2019-01-01)

Preliminary investigation of elevated collagen and blood‐clotting markers as potential noninvasive biomarkers for small cell lung cancer
by: Jeppe Thorlacius‐Ussing, et al.
Published: (2023-10-01)

Biomarker Research in Parkinson’s Disease Using Metabolite Profiling
by: Jesper F. Havelund, et al.
Published: (2017-08-01)

NMR and LC-MS-Based Metabolomics to Study Osmotic Stress in Lignan-Deficient Flax
by: Kamar Hamade, et al.
Published: (2021-02-01)

Ethyl Pyruvate Increases Post-Ischemic Levels of Mitochondrial Energy Metabolites: A <sup>13</sup>C-Labeled Cerebral Microdialysis Study
by: Kevin H. Nygaard, et al.
Published: (2020-07-01)

In Vivo Microdialysis of Endogenous and <sup>13</sup>C-labeled TCA Metabolites in Rat Brain: Reversible and Persistent Effects of Mitochondrial Inhibition and Transient Cerebral Ischemia
by: Jesper F. Havelund, et al.
Published: (2019-09-01)

Impaired glucocorticoid receptor expression in liver disrupts feeding-induced gene expression, glucose uptake, and glycogen storage
by: Stine M. Præstholm, et al.
Published: (2021-11-01)

Correlations Between LC-MS/MS-Detected Glycomics and NMR-Detected Metabolomics in Caenorhabditis elegans Development
by: M. Osman Sheikh, et al.
Published: (2019-06-01)

LC-MS and NMR Based Plant Metabolomics: A Comprehensive Phytochemical Investigation of <i>Symphytum anatolicum</i>
by: Hilal Kılınc, et al.
Published: (2023-10-01)

Characterisation of protein unfolding by NMR diffusion measurements
by: Jones, J, et al.
Published: (1997)

Esophageal cancer metabolite biomarkers detected by LC-MS and NMR methods.
by: Jian Zhang, et al.
Published: (2012-01-01)

Identification of Sulfur Mustard Hydrolysis Products by LC-UV-SPE NMR
by: Urs C. Meier
Published: (2014-04-01)

Classification of raw stingless bee honeys by bee species origins using the NMR- and LC-MS-based metabolomics approach
by: Ismail, Intan Safinar, et al.
Published: (2018)

Classification of Raw Stingless Bee Honeys by Bee Species Origins Using the NMR- and LC-MS-Based Metabolomics Approach
by: Muhammad Taufiq Atsifa Razali, et al.
Published: (2018)

Based on 1H NMR and LC-MS metabolomics reveals biomarkers with neuroprotective effects in multi-parts ginseng powder
by: Nanxi Zhang, et al.
Published: (2023-07-01)

Classification of Raw Stingless Bee Honeys by Bee Species Origins Using the NMR- and LC-MS-Based Metabolomics Approach
by: Muhammad Taufiq Atsifa Razali, et al.
Published: (2018-08-01)

An Integrated NMR, LC-DAD-MS, LC-QTOF Metabolomic Characterization of <i>Sartoria hedysaroides</i>: Correlation of Antioxidant and Enzyme Inhibitory Activity with Chemical Composition by Multivariate Data Analysis
by: Stefano Dall’Acqua, et al.
Published: (2022-01-01)

Effect of trans fatty acid intake on LC-MS and NMR plasma profiles.
by: Gözde Gürdeniz, et al.
Published: (2013-01-01)

<sup>1</sup>H-NMR and LC-MS Based Metabolomics Analysis of Wild and Cultivated <i>Amaranthus</i> spp.
by: Nolitha Nkobole, et al.
Published: (2021-02-01)

Postprandial Increase in Blood Plasma Levels of Tissue Factor–Bearing (and Other) Microvesicles Measured by Flow Cytometry: Fact or Artifact?
by: Morten Mørk, et al.
Published: (2018-04-01)

Qualitative Factor-Based Comparison of NMR, Targeted and Untargeted GC-MS and LC-MS on the Metabolomic Profiles of Rioja and Priorat Red Wines
by: Dimitrios Kioroglou, et al.
Published: (2020-09-01)

Characterisation of an Aromatic Plant-based Formula using UV-Vis Spectroscopy, LC–ESI(+)QTOF-MS and HPLC-DAD Analysis
by: Florina Bunghez, et al.
Published: (2013-11-01)

Harnessing NMR relaxation interference effects to characterise supramolecular assemblies
by: Baldwin, A, et al.
Published: (2016)

Harnessing NMR relaxation interference effects to characterise supramolecular assemblies.
by: Karunanithy, G, et al.
Published: (2016)

HYDROSTANNYLATION OF SULPHUR AND NITROGENSUBSTITUTED PHENYLACETYLENES: NMR CHARACTERISATION OF THE REACTION PRODUCTS
by: Lebl, Tomas, et al.
Published: (1999-04-01)

LC-DAD–ESI-MS/MS and NMR Analysis of Conifer Wood Specialized Metabolites
by: Andrzej Patyra, et al.
Published: (2022-10-01)

Rapid Identification of Bioactive Carbohydrazide Reaction Products by an LC-DAD-SPE-NMR Approach
by: Iva Habinovec, et al.
Published: (2015-12-01)

NMR CHARACTERIZATION OF SELF-ASSOCIATION DOMAINS PROMOTED BY INTERACTIONS WITH LC8 HUB PROTEIN
by: Elisar Barbar, et al.
Published: (2014-02-01)

Metabolic Profiling of a Porcine Combat Trauma-Injury Model Using NMR and Multi-Mode LC-MS Metabolomics—A Preliminary Study
by: Anna Karen Carrasco Laserna, et al.
Published: (2020-09-01)

Prospects and limitations of antibody-mediated clearing of lipoproteins from blood plasma prior to nanoparticle tracking analysis of extracellular vesicles
by: Morten Mørk, et al.
Published: (2017-12-01)

Characterisation of tri-ruthenium dihydride complexes through the computation of NMR parameters.
by: Al-Ibadi, M, et al.
Published: (2012)

Membrane Protein Structure Determination and Characterisation by Solution and Solid-State NMR
by: Vivien Yeh, et al.
Published: (2020-11-01)