Design, Rational Repurposing, Synthesis, In Vitro Evaluation, Homology Modeling and In Silico Study of Sulfuretin Analogs as Potential Antileishmanial Hit Compounds

Design, Rational Repurposing, Synthesis, In Vitro Evaluation, Homology Modeling and In Silico Study of Sulfuretin Analogs as Potential Antileishmanial Hit Compounds

Direct growth inhibition of infectious organisms coupled with immunomodulation to counteract the immunosuppressive environment might be a beneficial therapeutic approach. Herein, a library of sulfuretin analogs were developed with potential capabilities to inhibit production of the immunosuppressive...

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Bibliographic Details
Main Authors: Ahmed H.E. Hassan, Trong-Nhat Phan, Yeonwoo Choi, Suyeon Moon, Joo Hwan No, Yong Sup Lee
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Pharmaceuticals
Subjects:
antileishmanial agents
repurposing
<i>Leishmania donovani</i>
promastigotes
fumarate reductase
Online Access:https://www.mdpi.com/1424-8247/15/9/1058

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