The Role of Endocan in Selected Kidney Diseases
Endocan, previously referred to as an endothelial-cell-specific molecule-1 (ESM-1) is a member of a proteoglycan family that is secreted by vascular endothelial cells of different organs, mainly lungs and kidneys. It is assumed to participate in endothelial activation and the triggering of inflammat...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/17/6119 |
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| author | Magdalena Nalewajska Klaudia Gurazda Małgorzata Marchelek-Myśliwiec Andrzej Pawlik Violetta Dziedziejko |
| author_facet | Magdalena Nalewajska Klaudia Gurazda Małgorzata Marchelek-Myśliwiec Andrzej Pawlik Violetta Dziedziejko |
| author_sort | Magdalena Nalewajska |
| collection | DOAJ |
| description | Endocan, previously referred to as an endothelial-cell-specific molecule-1 (ESM-1) is a member of a proteoglycan family that is secreted by vascular endothelial cells of different organs, mainly lungs and kidneys. It is assumed to participate in endothelial activation and the triggering of inflammatory reactions, especially in microvasculatures. Thanks to its solubility in human fluids, i.e., urine and blood plasma, its stability and its low concentrations in physiological conditions, endocan has been proposed as an easily available, non-invasive biomarker for identifying and predicting the course of many diseases. Recently, endocan has been studied in relation to kidney diseases. In general, endocan levels have been linked to worse clinical outcomes of renal dysfunction; however, results are conflicting and require further evaluation. In this review, authors summarize available knowledge regarding the role of endocan in pathogenesis and progression of selected kidney diseases. |
| first_indexed | 2024-03-10T16:51:20Z |
| format | Article |
| id | doaj.art-ecfd1480d3a344f9bc6094f5097fff6a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T16:51:20Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ecfd1480d3a344f9bc6094f5097fff6a2023-11-20T11:18:17ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-08-012117611910.3390/ijms21176119The Role of Endocan in Selected Kidney DiseasesMagdalena Nalewajska0Klaudia Gurazda1Małgorzata Marchelek-Myśliwiec2Andrzej Pawlik3Violetta Dziedziejko4Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Powstańców Wlkp 72 Str, 70-111 Szczecin, PolandDepartment of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstańców Wlkp 72 Str, 70-111 Szczecin, PolandDepartment of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Powstańców Wlkp 72 Str, 70-111 Szczecin, PolandDepartment of Physiology, Pomeranian Medical University, Powstańców Wlkp 72 Str, 70-111 Szczecin, PolandDepartment of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstańców Wlkp 72 Str, 70-111 Szczecin, PolandEndocan, previously referred to as an endothelial-cell-specific molecule-1 (ESM-1) is a member of a proteoglycan family that is secreted by vascular endothelial cells of different organs, mainly lungs and kidneys. It is assumed to participate in endothelial activation and the triggering of inflammatory reactions, especially in microvasculatures. Thanks to its solubility in human fluids, i.e., urine and blood plasma, its stability and its low concentrations in physiological conditions, endocan has been proposed as an easily available, non-invasive biomarker for identifying and predicting the course of many diseases. Recently, endocan has been studied in relation to kidney diseases. In general, endocan levels have been linked to worse clinical outcomes of renal dysfunction; however, results are conflicting and require further evaluation. In this review, authors summarize available knowledge regarding the role of endocan in pathogenesis and progression of selected kidney diseases.https://www.mdpi.com/1422-0067/21/17/6119endocanESM-1acute kidney injurychronic kidney diseaserenal replacement therapykidney transplantation |
| spellingShingle | Magdalena Nalewajska Klaudia Gurazda Małgorzata Marchelek-Myśliwiec Andrzej Pawlik Violetta Dziedziejko The Role of Endocan in Selected Kidney Diseases International Journal of Molecular Sciences endocan ESM-1 acute kidney injury chronic kidney disease renal replacement therapy kidney transplantation |
| title | The Role of Endocan in Selected Kidney Diseases |
| title_full | The Role of Endocan in Selected Kidney Diseases |
| title_fullStr | The Role of Endocan in Selected Kidney Diseases |
| title_full_unstemmed | The Role of Endocan in Selected Kidney Diseases |
| title_short | The Role of Endocan in Selected Kidney Diseases |
| title_sort | role of endocan in selected kidney diseases |
| topic | endocan ESM-1 acute kidney injury chronic kidney disease renal replacement therapy kidney transplantation |
| url | https://www.mdpi.com/1422-0067/21/17/6119 |
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