Síntese de β-cetoésteres cíclicos: novo procedimento para ciclizações de Dieckmann empregando ALCL3 e trietilamina Synthesis of β-keto esters: new easy procedure for dieckmann cyclization employing aluminum chloride and triethylamine

Síntese de β-cetoésteres cíclicos: novo procedimento para ciclizações de Dieckmann empregando ALCL3 e trietilamina Synthesis of β-keto esters: new easy procedure for dieckmann cyclization employing aluminum chloride and triethylamine

<abstract language="eng">In this communication we describe a new methodology to Dieckmann cyclization of diethyl adipate (1) and diethyl pimelate (3) applying "push-pull" strategy using anhydrous aluminium trichloride and triethylamine in dichloromethane at room temperature...

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Bibliographic Details
Main Authors: Emerson P. Peçanha, Eliezer J. Barreiro, Carlos A. M. Fraga
Format: Article
Language:English
Published: Sociedade Brasileira de Química 1997-08-01
Series:Química Nova
Subjects:
Dieckmann cyclization
cyclopentanone derivatives
cyclohexanone derivatives
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40421997000400016
Description
Summary:<abstract language="eng">In this communication we describe a new methodology to Dieckmann cyclization of diethyl adipate (1) and diethyl pimelate (3) applying "push-pull" strategy using anhydrous aluminium trichloride and triethylamine in dichloromethane at room temperature. This method is very efficient, simple, safe and reproducible, giving the corresponding cyclic &#946;-keto ester derivatives in 84% and 71% yield, respectively.
ISSN:0100-4042
1678-7064

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