A unified framework for measuring selection on cellular lineages and traits

A unified framework for measuring selection on cellular lineages and traits

Intracellular states probed by gene expression profiles and metabolic activities are intrinsically noisy, causing phenotypic variations among cellular lineages. Understanding the adaptive and evolutionary roles of such variations requires clarifying their linkage to population growth rates. Extendin...

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Bibliographic Details
Main Authors: Shunpei Yamauchi, Takashi Nozoe, Reiko Okura, Edo Kussell, Yuichi Wakamoto
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-12-01
Series:eLife
Subjects:
cell lineage statistics
phenotypic heterogeneity
selection strength
fitness
cumulant
population growth rate
Online Access:https://elifesciences.org/articles/72299

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