The Role of the Epidermal Growth Factor Receptor in Diabetic Kidney Disease
The epidermal growth factor receptor (EGFR) is expressed in numerous cell types in the adult mammalian kidney and is activated by a family of EGF-like ligands. <i>EGFR</i> activation has been implicated in a variety of physiologic and pathophysiologic functions. There is increasing evide...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/21/3416 |
| _version_ | 1827647043810623488 |
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| author | Raymond C. Harris |
| author_facet | Raymond C. Harris |
| author_sort | Raymond C. Harris |
| collection | DOAJ |
| description | The epidermal growth factor receptor (EGFR) is expressed in numerous cell types in the adult mammalian kidney and is activated by a family of EGF-like ligands. <i>EGFR</i> activation has been implicated in a variety of physiologic and pathophysiologic functions. There is increasing evidence that aberrant <i>EGFR</i> activation is a mediator of progressive kidney injury in diabetic kidney disease. This review will highlight recent studies indicating its potential role and mechanisms of injury of both glomerular and tubular cells in development and progression of diabetic kidney disease. |
| first_indexed | 2024-03-09T19:11:48Z |
| format | Article |
| id | doaj.art-ed01d6558bf447cf8be12db613ab3fd3 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T19:11:48Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-ed01d6558bf447cf8be12db613ab3fd32023-11-24T04:08:24ZengMDPI AGCells2073-44092022-10-011121341610.3390/cells11213416The Role of the Epidermal Growth Factor Receptor in Diabetic Kidney DiseaseRaymond C. Harris0Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt Center for Kidney Disease, Vanderbilt University Medical Center, Nashville, TN 37232, USAThe epidermal growth factor receptor (EGFR) is expressed in numerous cell types in the adult mammalian kidney and is activated by a family of EGF-like ligands. <i>EGFR</i> activation has been implicated in a variety of physiologic and pathophysiologic functions. There is increasing evidence that aberrant <i>EGFR</i> activation is a mediator of progressive kidney injury in diabetic kidney disease. This review will highlight recent studies indicating its potential role and mechanisms of injury of both glomerular and tubular cells in development and progression of diabetic kidney disease.https://www.mdpi.com/2073-4409/11/21/3416EGFkidneydiabetesnephropathy |
| spellingShingle | Raymond C. Harris The Role of the Epidermal Growth Factor Receptor in Diabetic Kidney Disease Cells EGF kidney diabetes nephropathy |
| title | The Role of the Epidermal Growth Factor Receptor in Diabetic Kidney Disease |
| title_full | The Role of the Epidermal Growth Factor Receptor in Diabetic Kidney Disease |
| title_fullStr | The Role of the Epidermal Growth Factor Receptor in Diabetic Kidney Disease |
| title_full_unstemmed | The Role of the Epidermal Growth Factor Receptor in Diabetic Kidney Disease |
| title_short | The Role of the Epidermal Growth Factor Receptor in Diabetic Kidney Disease |
| title_sort | role of the epidermal growth factor receptor in diabetic kidney disease |
| topic | EGF kidney diabetes nephropathy |
| url | https://www.mdpi.com/2073-4409/11/21/3416 |
| work_keys_str_mv | AT raymondcharris theroleoftheepidermalgrowthfactorreceptorindiabetickidneydisease AT raymondcharris roleoftheepidermalgrowthfactorreceptorindiabetickidneydisease |