Identification of circRNA biomarkers in osteosarcoma: An updated systematic review and meta-analysis
Circular RNAs (circRNAs) play a crucial role in cancer development and progression. This study aimed to identify potential circRNA biomarkers for osteosarcoma. Articles published from January 2010 to September 2023 were searched across eight databases to compare circRNA expression profiles in osteos...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2024-06-01
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| Series: | Non-coding RNA Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468054024000076 |
| _version_ | 1797234078207967232 |
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| author | Chunbin Zhou Lois Balmer Manshu Song Gehendra Mahara Kezhou Wu Wei Wang Hu Wang |
| author_facet | Chunbin Zhou Lois Balmer Manshu Song Gehendra Mahara Kezhou Wu Wei Wang Hu Wang |
| author_sort | Chunbin Zhou |
| collection | DOAJ |
| description | Circular RNAs (circRNAs) play a crucial role in cancer development and progression. This study aimed to identify potential circRNA biomarkers for osteosarcoma. Articles published from January 2010 to September 2023 were searched across eight databases to compare circRNA expression profiles in osteosarcoma and control samples (human, animal and cell lines). Meta-analysis was conducted under a random effects model. Subgroup analysis of circRNAs in different samples and tissues was performed. Diagnostic value was evaluated using receiver operator characteristic curves. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis explored functions of circRNA host genes. A circRNA-miRNA-mRNA axis depicted the regulatory mechanism in osteosarcoma. Among 1356 circRNAs with differential expression were identified across 226 original studies, only 74 were reported in at least three published sub-studies. Meta-analysis identified 58 dysregulated circRNAs (52 upregulated and 6 downregulated). Eleven circRNAs consistently showed dysregulation in tissues and cell lines, with hsa_circ_0005721 showing potential as a circulating biomarker in osteosarcoma. Sensitivity analysis demonstrated 97 % consistency. The overall area under the curve was 0.87 (95 % CI, 0.83–0.89). GO and KEGG enrichment analyses revealed host gene involvement in cancer. The circRNA-miRNA-mRNA axis revealed the regulatory axis and interactions within osteosarcoma specifically. This study demonstrates circRNAs as potential diagnostic biomarkers for osteosarcoma. Consistently reported dysregulated circRNAs are potential biomarkers in osteosarcoma pathogenesis, with hsa_circ_0005721 as a potential circulating biomarker for diagnosis and treatment. |
| first_indexed | 2024-04-24T16:26:20Z |
| format | Article |
| id | doaj.art-ed0271088c204055b0007f0220d713b8 |
| institution | Directory Open Access Journal |
| issn | 2468-0540 |
| language | English |
| last_indexed | 2024-04-24T16:26:20Z |
| publishDate | 2024-06-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Non-coding RNA Research |
| spelling | doaj.art-ed0271088c204055b0007f0220d713b82024-03-31T04:37:46ZengKeAi Communications Co., Ltd.Non-coding RNA Research2468-05402024-06-0192341349Identification of circRNA biomarkers in osteosarcoma: An updated systematic review and meta-analysisChunbin Zhou0Lois Balmer1Manshu Song2Gehendra Mahara3Kezhou Wu4Wei Wang5Hu Wang6Center for Precision Health, School of Medical and Health Science, Edith Cowan University, Perth, WA, 6027, Australia; Department of Orthopaedics, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, 515041, ChinaCenter for Precision Health, School of Medical and Health Science, Edith Cowan University, Perth, WA, 6027, AustraliaCenter for Precision Health, School of Medical and Health Science, Edith Cowan University, Perth, WA, 6027, AustraliaClinical Research Center, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, 515041, China; Department of Cardiovascular Medicine, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, 515041, ChinaDepartment of Orthopaedics, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, 515041, ChinaCenter for Precision Health, School of Medical and Health Science, Edith Cowan University, Perth, WA, 6027, Australia; The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, 515041, China; Corresponding author. Room 521, Building 21/270 Joondalup Drive, Perth, WA, 6027, Australia.Department of Orthopaedics, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, 515041, China; Minimally Invasive Spine Center, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, 515041, China; Corresponding author. No.57 Changping Road, Shantou, Guangdong, 515041, China.Circular RNAs (circRNAs) play a crucial role in cancer development and progression. This study aimed to identify potential circRNA biomarkers for osteosarcoma. Articles published from January 2010 to September 2023 were searched across eight databases to compare circRNA expression profiles in osteosarcoma and control samples (human, animal and cell lines). Meta-analysis was conducted under a random effects model. Subgroup analysis of circRNAs in different samples and tissues was performed. Diagnostic value was evaluated using receiver operator characteristic curves. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis explored functions of circRNA host genes. A circRNA-miRNA-mRNA axis depicted the regulatory mechanism in osteosarcoma. Among 1356 circRNAs with differential expression were identified across 226 original studies, only 74 were reported in at least three published sub-studies. Meta-analysis identified 58 dysregulated circRNAs (52 upregulated and 6 downregulated). Eleven circRNAs consistently showed dysregulation in tissues and cell lines, with hsa_circ_0005721 showing potential as a circulating biomarker in osteosarcoma. Sensitivity analysis demonstrated 97 % consistency. The overall area under the curve was 0.87 (95 % CI, 0.83–0.89). GO and KEGG enrichment analyses revealed host gene involvement in cancer. The circRNA-miRNA-mRNA axis revealed the regulatory axis and interactions within osteosarcoma specifically. This study demonstrates circRNAs as potential diagnostic biomarkers for osteosarcoma. Consistently reported dysregulated circRNAs are potential biomarkers in osteosarcoma pathogenesis, with hsa_circ_0005721 as a potential circulating biomarker for diagnosis and treatment.http://www.sciencedirect.com/science/article/pii/S2468054024000076OsteosarcomaCircRNAMeta-analysisBioinformaticsSystematic review |
| spellingShingle | Chunbin Zhou Lois Balmer Manshu Song Gehendra Mahara Kezhou Wu Wei Wang Hu Wang Identification of circRNA biomarkers in osteosarcoma: An updated systematic review and meta-analysis Non-coding RNA Research Osteosarcoma CircRNA Meta-analysis Bioinformatics Systematic review |
| title | Identification of circRNA biomarkers in osteosarcoma: An updated systematic review and meta-analysis |
| title_full | Identification of circRNA biomarkers in osteosarcoma: An updated systematic review and meta-analysis |
| title_fullStr | Identification of circRNA biomarkers in osteosarcoma: An updated systematic review and meta-analysis |
| title_full_unstemmed | Identification of circRNA biomarkers in osteosarcoma: An updated systematic review and meta-analysis |
| title_short | Identification of circRNA biomarkers in osteosarcoma: An updated systematic review and meta-analysis |
| title_sort | identification of circrna biomarkers in osteosarcoma an updated systematic review and meta analysis |
| topic | Osteosarcoma CircRNA Meta-analysis Bioinformatics Systematic review |
| url | http://www.sciencedirect.com/science/article/pii/S2468054024000076 |
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