Base-Resolution Analysis of DNA Methylation Patterns Downstream of Dnmt3a in Mouse Naïve B Cells

Base-Resolution Analysis of DNA Methylation Patterns Downstream of Dnmt3a in Mouse Naïve B Cells

The DNA methyltransferase, Dnmt3a, is dynamically regulated throughout mammalian B cell development and upon activation by antigenic stimulation. Dnmt3a inactivation in hematopoietic stem cells has been shown to drive B cell-related malignancies, including chronic lymphocytic leukemia, and associate...

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Bibliographic Details
Main Authors: Christopher G. Duncan, Hrisavgi D. Kondilis-Mangum, Sara A. Grimm, Pierre R. Bushel, Kaliopi Chrysovergis, John D. Roberts, Frederick L. Tyson, B. Alex Merrick, Paul A. Wade
Format: Article
Language:English
Published: Oxford University Press 2018-03-01
Series:G3: Genes, Genomes, Genetics
Subjects:
B cell
DNA methylation
Dnmt3a
whole genome bisulfite sequencing
gene body
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.117.300446

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