Relation between Serum Uric Acid and Peripheral Neuropathy in Cases of Type 2 Diabetes Mellitus
Background: Peripheral neuropathy is a common sequel of diabetes mellitus type 2, and may occur as an initial manifestation of diabetes. The role of uric acid in diabetic neuropathy as a microvascular complication of diabetes type 2 has been reported in numerous studies.Aim of the Work: The objectiv...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Al-Azhar University, Faculty of Medicine (Damietta)
2023-01-01
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| Series: | International Journal of Medical Arts |
| Subjects: | |
| Online Access: | https://ijma.journals.ekb.eg/article_292144_e3bcdc17af3c72caaf5c1dd24216445e.pdf |
| Summary: | Background: Peripheral neuropathy is a common sequel of diabetes mellitus type 2, and may occur as an initial manifestation of diabetes. The role of uric acid in diabetic neuropathy as a microvascular complication of diabetes type 2 has been reported in numerous studies.Aim of the Work: The objective of the study is to assess the relationship between serum uric acid levels and diabetic neuropathy in cases with diabetes mellitus type 2. Patients and Methods: A case-controlled study included 168 cases with type 2 diabetes mellitus, conducted at internal medicine and neurology departments. Two groups of diabetic patients [type 2 DM] each one was 84 in number; 1st one diabetic with peripheral neuropathy and 2nd group was diabetics without peripheral neuropathy. All patients submitted to history taking, general and neurological examination, biochemical study, and electro-physiological examination. Results: The serum uric acid mean level was a statistically significant higher in the 1st group in comparison with the 2nd group [4.71 ± 0.97 vs. 4.35 ± 0.9]. The severity of polyneuropathy in the 1st group showed that 38 patients had mild diabetic peripheral neuropathy [DPN], while 22 patients had moderate DPN and 24 patients had severe DPN. Uric acid levels in these three subgroups were respectively as follows: [4.6 ± 0.8] mg/dl, [4.9 ± 0.5] mg/dl and [5.3 ± 0.6] mg/dl. Regarding the relation of severity of peripheral polyneuropathy to serum uric acid level, there was a statistically significant relation between mild and moderate poly-neuropathy and a statistically significant relation between Mild to severe polyneuropathy. The logistic regression model revealed that an increase in uric acid level is an important indicator for a more severe degree of peripheral neuropathy.Conclusion: The severity of diabetic polyneuropathy is increased with the increase of uric acid serum level. |
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| ISSN: | 2636-4174 2682-3780 |