Retrospective evaluation of risk factors for development of kidney injury after parenteral furosemide treatment of left‐sided congestive heart failure in dogs
Abstract Background Kidney injury (KI) has been documented in dogs treated with furosemide for left‐sided congestive heart failure (CHF). Hypothesis/Objectives Determine risk factors for development of KI in furosemide‐treated dogs and determine the effect of KI on survival. Animals Seventy‐nine cli...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-11-01
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| Series: | Journal of Veterinary Internal Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jvim.16571 |
| _version_ | 1797976889383452672 |
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| author | Maria E. Giorgi Jonathan P. Mochel Lingnan Yuan Darcy B. Adin Jessica L. Ward |
| author_facet | Maria E. Giorgi Jonathan P. Mochel Lingnan Yuan Darcy B. Adin Jessica L. Ward |
| author_sort | Maria E. Giorgi |
| collection | DOAJ |
| description | Abstract Background Kidney injury (KI) has been documented in dogs treated with furosemide for left‐sided congestive heart failure (CHF). Hypothesis/Objectives Determine risk factors for development of KI in furosemide‐treated dogs and determine the effect of KI on survival. Animals Seventy‐nine client‐owned dogs receiving parenteral furosemide for CHF. Methods Serum creatinine (sCr) and electrolyte concentrations were determined during hospitalization and at first outpatient reevaluation to detect and stage KI (increase in sCr ≥0.3 mg/dL). Furosemide dosage administered between timepoints was calculated. Multivariable modeling was performed to identify predictors of KI and percent change in serum biochemistry results over time. Results Kidney injury was identified in 38/79 (48%) dogs and mostly occurred during hospitalization. Kidney injury was Grade I in 25 dogs, Grade II in 9 dogs, and Grade III in 4 dogs. Higher blood pressure was associated with acute KI during hospitalization (odds ratio, 1.03; 95% confidence interval [95% CI] 1.01‐1.07; P = .03) whereas PO furosemide dosage was associated with KI after hospital discharge (odds ratio, 7.77; 95% CI, 2.05‐68.6; P = .02). Baseline sCr and use of a furosemide continuous rate infusion were not associated with increased risk of KI. Kidney injury was not associated with long‐term outcome. Of 13 dogs with Grade II‐III KI, azotemia was reversible in 9 dogs, and 6 dogs survived >1 year after KI. Conclusions and Clinical Importance In this cohort of dogs receiving parenteral furosemide for CHF, KI was common, mostly nonazotemic (Grade I), and did not impact survival. |
| first_indexed | 2024-04-11T04:58:10Z |
| format | Article |
| id | doaj.art-ed05b7b1ea684dcda3c4856442aa5b55 |
| institution | Directory Open Access Journal |
| issn | 0891-6640 1939-1676 |
| language | English |
| last_indexed | 2024-04-11T04:58:10Z |
| publishDate | 2022-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj.art-ed05b7b1ea684dcda3c4856442aa5b552022-12-26T07:32:23ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762022-11-013662042205210.1111/jvim.16571Retrospective evaluation of risk factors for development of kidney injury after parenteral furosemide treatment of left‐sided congestive heart failure in dogsMaria E. Giorgi0Jonathan P. Mochel1Lingnan Yuan2Darcy B. Adin3Jessica L. Ward4Department of Veterinary Clinical Sciences College of Veterinary Medicine, Iowa State University Ames Iowa USADepartment of Biomedical Sciences, SMART Pharmacology College of Veterinary Medicine, Iowa State University Ames Iowa USADepartment of Biomedical Sciences, SMART Pharmacology College of Veterinary Medicine, Iowa State University Ames Iowa USADepartment of Large Animal Clinical Sciences College of Veterinary Medicine, University of Florida Gainesville Florida USADepartment of Veterinary Clinical Sciences College of Veterinary Medicine, Iowa State University Ames Iowa USAAbstract Background Kidney injury (KI) has been documented in dogs treated with furosemide for left‐sided congestive heart failure (CHF). Hypothesis/Objectives Determine risk factors for development of KI in furosemide‐treated dogs and determine the effect of KI on survival. Animals Seventy‐nine client‐owned dogs receiving parenteral furosemide for CHF. Methods Serum creatinine (sCr) and electrolyte concentrations were determined during hospitalization and at first outpatient reevaluation to detect and stage KI (increase in sCr ≥0.3 mg/dL). Furosemide dosage administered between timepoints was calculated. Multivariable modeling was performed to identify predictors of KI and percent change in serum biochemistry results over time. Results Kidney injury was identified in 38/79 (48%) dogs and mostly occurred during hospitalization. Kidney injury was Grade I in 25 dogs, Grade II in 9 dogs, and Grade III in 4 dogs. Higher blood pressure was associated with acute KI during hospitalization (odds ratio, 1.03; 95% confidence interval [95% CI] 1.01‐1.07; P = .03) whereas PO furosemide dosage was associated with KI after hospital discharge (odds ratio, 7.77; 95% CI, 2.05‐68.6; P = .02). Baseline sCr and use of a furosemide continuous rate infusion were not associated with increased risk of KI. Kidney injury was not associated with long‐term outcome. Of 13 dogs with Grade II‐III KI, azotemia was reversible in 9 dogs, and 6 dogs survived >1 year after KI. Conclusions and Clinical Importance In this cohort of dogs receiving parenteral furosemide for CHF, KI was common, mostly nonazotemic (Grade I), and did not impact survival.https://doi.org/10.1111/jvim.16571acute renal failurecardiorenal syndromecardiovascularclinical chemistryclinical pathologyheart failure |
| spellingShingle | Maria E. Giorgi Jonathan P. Mochel Lingnan Yuan Darcy B. Adin Jessica L. Ward Retrospective evaluation of risk factors for development of kidney injury after parenteral furosemide treatment of left‐sided congestive heart failure in dogs Journal of Veterinary Internal Medicine acute renal failure cardiorenal syndrome cardiovascular clinical chemistry clinical pathology heart failure |
| title | Retrospective evaluation of risk factors for development of kidney injury after parenteral furosemide treatment of left‐sided congestive heart failure in dogs |
| title_full | Retrospective evaluation of risk factors for development of kidney injury after parenteral furosemide treatment of left‐sided congestive heart failure in dogs |
| title_fullStr | Retrospective evaluation of risk factors for development of kidney injury after parenteral furosemide treatment of left‐sided congestive heart failure in dogs |
| title_full_unstemmed | Retrospective evaluation of risk factors for development of kidney injury after parenteral furosemide treatment of left‐sided congestive heart failure in dogs |
| title_short | Retrospective evaluation of risk factors for development of kidney injury after parenteral furosemide treatment of left‐sided congestive heart failure in dogs |
| title_sort | retrospective evaluation of risk factors for development of kidney injury after parenteral furosemide treatment of left sided congestive heart failure in dogs |
| topic | acute renal failure cardiorenal syndrome cardiovascular clinical chemistry clinical pathology heart failure |
| url | https://doi.org/10.1111/jvim.16571 |
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