Engineering of small-molecule lipidic prodrugs as novel nanomedicines for enhanced drug delivery
Abstract A widely established prodrug strategy can effectively optimize the unappealing properties of therapeutic agents in cancer treatment. Among them, lipidic prodrugs extremely uplift the physicochemical properties, site-specificity, and antitumor activities of therapeutic agents while reducing...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-01-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-022-01257-4 |
| _version_ | 1811187742204231680 |
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| author | Lingling Huang Jianmiao Yang Tiantian Wang Jianqing Gao Donghang Xu |
| author_facet | Lingling Huang Jianmiao Yang Tiantian Wang Jianqing Gao Donghang Xu |
| author_sort | Lingling Huang |
| collection | DOAJ |
| description | Abstract A widely established prodrug strategy can effectively optimize the unappealing properties of therapeutic agents in cancer treatment. Among them, lipidic prodrugs extremely uplift the physicochemical properties, site-specificity, and antitumor activities of therapeutic agents while reducing systemic toxicity. Although great perspectives have been summarized in the progress of prodrug-based nanoplatforms, no attention has been paid to emphasizing the rational design of small-molecule lipidic prodrugs (SLPs). With the aim of outlining the prospect of the SLPs approach, the review will first provide an overview of conjugation strategies that are amenable to SLPs fabrication. Then, the rational design of SLPs in response to the physiological barriers of chemotherapeutic agents is highlighted. Finally, their biomedical applications are also emphasized with special functions, followed by a brief introduction of the promising opportunities and potential challenges of SLPs-based drug delivery systems (DDSs) in clinical application. Graphical Abstract |
| first_indexed | 2024-04-11T14:07:31Z |
| format | Article |
| id | doaj.art-ed08acb75a284ceab255a834cdfbcd9f |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-11T14:07:31Z |
| publishDate | 2022-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-ed08acb75a284ceab255a834cdfbcd9f2022-12-22T04:19:50ZengBMCJournal of Nanobiotechnology1477-31552022-01-0120111510.1186/s12951-022-01257-4Engineering of small-molecule lipidic prodrugs as novel nanomedicines for enhanced drug deliveryLingling Huang0Jianmiao Yang1Tiantian Wang2Jianqing Gao3Donghang Xu4Department of Pharmacy, The Second Affiliated Hospital, Zhejiang University School of MedicineTaizhou Hospital of Zhejiang ProvinceDepartment of Pharmacy, The Second Affiliated Hospital, Zhejiang University School of MedicineZhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang UniversityDepartment of Pharmacy, The Second Affiliated Hospital, Zhejiang University School of MedicineAbstract A widely established prodrug strategy can effectively optimize the unappealing properties of therapeutic agents in cancer treatment. Among them, lipidic prodrugs extremely uplift the physicochemical properties, site-specificity, and antitumor activities of therapeutic agents while reducing systemic toxicity. Although great perspectives have been summarized in the progress of prodrug-based nanoplatforms, no attention has been paid to emphasizing the rational design of small-molecule lipidic prodrugs (SLPs). With the aim of outlining the prospect of the SLPs approach, the review will first provide an overview of conjugation strategies that are amenable to SLPs fabrication. Then, the rational design of SLPs in response to the physiological barriers of chemotherapeutic agents is highlighted. Finally, their biomedical applications are also emphasized with special functions, followed by a brief introduction of the promising opportunities and potential challenges of SLPs-based drug delivery systems (DDSs) in clinical application. Graphical Abstracthttps://doi.org/10.1186/s12951-022-01257-4CancerSmall moleculeLipidic prodrugNanomedicineDrug delivery |
| spellingShingle | Lingling Huang Jianmiao Yang Tiantian Wang Jianqing Gao Donghang Xu Engineering of small-molecule lipidic prodrugs as novel nanomedicines for enhanced drug delivery Journal of Nanobiotechnology Cancer Small molecule Lipidic prodrug Nanomedicine Drug delivery |
| title | Engineering of small-molecule lipidic prodrugs as novel nanomedicines for enhanced drug delivery |
| title_full | Engineering of small-molecule lipidic prodrugs as novel nanomedicines for enhanced drug delivery |
| title_fullStr | Engineering of small-molecule lipidic prodrugs as novel nanomedicines for enhanced drug delivery |
| title_full_unstemmed | Engineering of small-molecule lipidic prodrugs as novel nanomedicines for enhanced drug delivery |
| title_short | Engineering of small-molecule lipidic prodrugs as novel nanomedicines for enhanced drug delivery |
| title_sort | engineering of small molecule lipidic prodrugs as novel nanomedicines for enhanced drug delivery |
| topic | Cancer Small molecule Lipidic prodrug Nanomedicine Drug delivery |
| url | https://doi.org/10.1186/s12951-022-01257-4 |
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