A specific, non-immune system-related isoform of the human inducible nitric oxide synthase is expressed during differentiation of human stem cells into various cell types

A specific, non-immune system-related isoform of the human inducible nitric oxide synthase is expressed during differentiation of human stem cells into various cell types

Abstract Background NOS2 expression is mostly found in bacteria-exposed or cytokine-treated tissues and is mostly connected to innate immune reactions. There are three isoforms of NOS2 (NOS2-1 to -3). In RNA-seq data sets, analyzing inflammatory gene expression, only expression of the NOS2-1 mRNA is...

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Bibliographic Details
Main Authors: Fabian Gather, Irmgard Ihrig-Biedert, Paul Kohlhas, Tamara Krutenko, Michael Peitz, Oliver Brüstle, Andrea Pautz, Hartmut Kleinert
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Cell Communication and Signaling
Subjects:
iNOS
NOS2
hPSCs
Online Access:https://doi.org/10.1186/s12964-022-00855-x

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