Sea bass (Lateolabrax maculatus) exerts anti‐ulcerative colitis effects through gut microbiota modulation
Abstract Traditional Chinese medicinal books have noted that sea bass (Lateolabrax maculatus) may effectively manage inflammation‐linked conditions. The folk use of sea bass during pregnancy as nutritional care is also popular in China. However, scientific verification of health benefits of sea bass...
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| Format: | Article |
| Language: | English |
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Wiley
2024-03-01
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| Series: | Food Frontiers |
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| Online Access: | https://doi.org/10.1002/fft2.344 |
| _version_ | 1827314846879711232 |
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| author | Jiali Chen Yuhang Xiao Kejian Wang Xiuqiong Fu Yueyao Fan Muhammad Jahangir Hossen Yingjie Chen Weibin Bai Zhiling Yu Baojun Xu |
| author_facet | Jiali Chen Yuhang Xiao Kejian Wang Xiuqiong Fu Yueyao Fan Muhammad Jahangir Hossen Yingjie Chen Weibin Bai Zhiling Yu Baojun Xu |
| author_sort | Jiali Chen |
| collection | DOAJ |
| description | Abstract Traditional Chinese medicinal books have noted that sea bass (Lateolabrax maculatus) may effectively manage inflammation‐linked conditions. The folk use of sea bass during pregnancy as nutritional care is also popular in China. However, scientific verification of health benefits of sea bass remains a lack of report. Our previous studies have proven that sea bass has therapeutic benefits for ulcerative colitis (UC). However, a further investigation on the interacted mechanism among sea bass, UC, and gut microbiota has still not been fully explored and clarified. Hence, gut microbiota as the crucial mechanism of UC was evaluated. Gut ecosystem was analyzed by 16sRNA sequencing. The potential microbial biomarker was found through LEfSe analysis. Flow cytometry was then further applied to verify the identified biomarker. Results revealed that sea bass could effectively recover the abundance of UC‐mediated microbiota. LEfSe analysis found that Christensenellaceae could be identified as the potential biomarker for sea bass‐mediated gut microbiota in UC. Further in vitro study conjointly confirmed that the identified bioactive constituent of sea bass could significantly promote the growth of Christensenella minuta. Sufficient results derived that sea bass could ameliorate UC through gut microbiota modulation. C. minuta was identified as the promising microbial biomarker for the mechanism of sea bass in treating intestinal inflammation. It provided further elucidation on the pharmacological mechanism of sea bass in alleviating UC through gut microbiota modulation. It is a crucial driving force for the progress of scientific research on the dietary therapy of sea bass. |
| first_indexed | 2024-04-24T22:44:10Z |
| format | Article |
| id | doaj.art-ed0b96f63d4940a89d6f5fdb1aa4a0de |
| institution | Directory Open Access Journal |
| issn | 2643-8429 |
| language | English |
| last_indexed | 2024-04-24T22:44:10Z |
| publishDate | 2024-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Food Frontiers |
| spelling | doaj.art-ed0b96f63d4940a89d6f5fdb1aa4a0de2024-03-18T16:46:15ZengWileyFood Frontiers2643-84292024-03-015252253410.1002/fft2.344Sea bass (Lateolabrax maculatus) exerts anti‐ulcerative colitis effects through gut microbiota modulationJiali Chen0Yuhang Xiao1Kejian Wang2Xiuqiong Fu3Yueyao Fan4Muhammad Jahangir Hossen5Yingjie Chen6Weibin Bai7Zhiling Yu8Baojun Xu9Department of Food Science and Engineering Institute of Food Safety and Nutrition Guangdong Engineering Technology Center of Food Safety Molecular Rapid Detection Jinan University Guangzhou ChinaDepartment of Food Science and Engineering Institute of Food Safety and Nutrition Guangdong Engineering Technology Center of Food Safety Molecular Rapid Detection Jinan University Guangzhou ChinaInnovative Institute of Chinese Medicine and Pharmacy, Shandong University of Traditional Chinese MedicineShandong ChinaCentre for Cancer and Inflammation Research School of Chinese Medicine Hong Kong Baptist University Hong Kong ChinaDepartment of Food Science and Engineering Institute of Food Safety and Nutrition Guangdong Engineering Technology Center of Food Safety Molecular Rapid Detection Jinan University Guangzhou ChinaDepartment of Animal Science Patuakhali Science and Technology University Patuakhali BangladeshCentre for Cancer and Inflammation Research School of Chinese Medicine Hong Kong Baptist University Hong Kong ChinaDepartment of Food Science and Engineering Institute of Food Safety and Nutrition Guangdong Engineering Technology Center of Food Safety Molecular Rapid Detection Jinan University Guangzhou ChinaCentre for Cancer and Inflammation Research School of Chinese Medicine Hong Kong Baptist University Hong Kong ChinaFood Science and Technology Program Department of Life Sciences BNU‐HKBU United International College Zhuhai ChinaAbstract Traditional Chinese medicinal books have noted that sea bass (Lateolabrax maculatus) may effectively manage inflammation‐linked conditions. The folk use of sea bass during pregnancy as nutritional care is also popular in China. However, scientific verification of health benefits of sea bass remains a lack of report. Our previous studies have proven that sea bass has therapeutic benefits for ulcerative colitis (UC). However, a further investigation on the interacted mechanism among sea bass, UC, and gut microbiota has still not been fully explored and clarified. Hence, gut microbiota as the crucial mechanism of UC was evaluated. Gut ecosystem was analyzed by 16sRNA sequencing. The potential microbial biomarker was found through LEfSe analysis. Flow cytometry was then further applied to verify the identified biomarker. Results revealed that sea bass could effectively recover the abundance of UC‐mediated microbiota. LEfSe analysis found that Christensenellaceae could be identified as the potential biomarker for sea bass‐mediated gut microbiota in UC. Further in vitro study conjointly confirmed that the identified bioactive constituent of sea bass could significantly promote the growth of Christensenella minuta. Sufficient results derived that sea bass could ameliorate UC through gut microbiota modulation. C. minuta was identified as the promising microbial biomarker for the mechanism of sea bass in treating intestinal inflammation. It provided further elucidation on the pharmacological mechanism of sea bass in alleviating UC through gut microbiota modulation. It is a crucial driving force for the progress of scientific research on the dietary therapy of sea bass.https://doi.org/10.1002/fft2.344biomarkerChristensenella minutagut microbiotasea bassulcerative colitis |
| spellingShingle | Jiali Chen Yuhang Xiao Kejian Wang Xiuqiong Fu Yueyao Fan Muhammad Jahangir Hossen Yingjie Chen Weibin Bai Zhiling Yu Baojun Xu Sea bass (Lateolabrax maculatus) exerts anti‐ulcerative colitis effects through gut microbiota modulation Food Frontiers biomarker Christensenella minuta gut microbiota sea bass ulcerative colitis |
| title | Sea bass (Lateolabrax maculatus) exerts anti‐ulcerative colitis effects through gut microbiota modulation |
| title_full | Sea bass (Lateolabrax maculatus) exerts anti‐ulcerative colitis effects through gut microbiota modulation |
| title_fullStr | Sea bass (Lateolabrax maculatus) exerts anti‐ulcerative colitis effects through gut microbiota modulation |
| title_full_unstemmed | Sea bass (Lateolabrax maculatus) exerts anti‐ulcerative colitis effects through gut microbiota modulation |
| title_short | Sea bass (Lateolabrax maculatus) exerts anti‐ulcerative colitis effects through gut microbiota modulation |
| title_sort | sea bass lateolabrax maculatus exerts anti ulcerative colitis effects through gut microbiota modulation |
| topic | biomarker Christensenella minuta gut microbiota sea bass ulcerative colitis |
| url | https://doi.org/10.1002/fft2.344 |
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