Epidemiological characteristics and risk factors of lung adenocarcinoma: A retrospective observational study from North China
BackgroundThe main aim of the study was to determine the risk factors of lung adenocarcinoma and to analyze the variations in the incidence of lung adenocarcinoma according to time, sex, and smoking status in North China.MethodsPatients with lung cancer in local household registries diagnosed and tr...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.892571/full |
| _version_ | 1811344155853455360 |
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| author | Daojuan Li Jin Shi Xiaoping Dong Di Liang Jing Jin Yutong He |
| author_facet | Daojuan Li Jin Shi Xiaoping Dong Di Liang Jing Jin Yutong He |
| author_sort | Daojuan Li |
| collection | DOAJ |
| description | BackgroundThe main aim of the study was to determine the risk factors of lung adenocarcinoma and to analyze the variations in the incidence of lung adenocarcinoma according to time, sex, and smoking status in North China.MethodsPatients with lung cancer in local household registries diagnosed and treated for the first time in the investigating hospital were enrolled from 11 cities in North China between 2010 and 2017. Baseline characteristics and tumor-related information were extracted from the patients’ hospital medical record, clinical course records, and clinical examination. Some of the variables, such as smoking, alcohol consumption, medical history, and family history of cancer, were obtained from interviews with the enrolled patients. The statistical method used were the chi-square test and multi-factor logistic regression analysis. The time trend was statistically analyzed using Joinpoint regression models, and p values were calculated.ResultsA total of 23,674 lung cancer cases were enrolled. People in severely polluted cities were at higher risk for lung adenocarcinoma (p < 0.001). Most patients with lung adenocarcinoma had no history of lung-related diseases (p = 0.001). Anatomically, lung adenocarcinoma was more likely to occur in the right lung (p < 0.001). Non-manual labor workers were more likely to develop from lung adenocarcinoma than manual workers (p = 0.015). Notably, non-smokers were more likely to develop lung adenocarcinoma than smokers (p < 0.001). The proportion of lung adenocarcinoma increased significantly in Hebei Province (p < 0.001). Among non-smokers, the proportion of lung adenocarcinoma showed a higher rise than in smokers (p < 0.001).ConclusionsLung adenocarcinoma is the most common histological type of lung cancer in North China (Hebei Province), and the proportion of lung adenocarcinoma is increasing, especially among non-smokers. Lung adenocarcinoma is more common in women, severely polluted cities, individuals with no history of lung-related diseases, in the right lung, and in non-smokers. These can serve as a great guide in determining the accuracy of lung adenocarcinoma high-risk groups and lung cancer risk assessment models. |
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| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-13T19:42:45Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-ed0e8cc5c0634de28711001f76f96a6b2022-12-22T02:32:50ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-08-011210.3389/fonc.2022.892571892571Epidemiological characteristics and risk factors of lung adenocarcinoma: A retrospective observational study from North ChinaDaojuan LiJin ShiXiaoping DongDi LiangJing JinYutong HeBackgroundThe main aim of the study was to determine the risk factors of lung adenocarcinoma and to analyze the variations in the incidence of lung adenocarcinoma according to time, sex, and smoking status in North China.MethodsPatients with lung cancer in local household registries diagnosed and treated for the first time in the investigating hospital were enrolled from 11 cities in North China between 2010 and 2017. Baseline characteristics and tumor-related information were extracted from the patients’ hospital medical record, clinical course records, and clinical examination. Some of the variables, such as smoking, alcohol consumption, medical history, and family history of cancer, were obtained from interviews with the enrolled patients. The statistical method used were the chi-square test and multi-factor logistic regression analysis. The time trend was statistically analyzed using Joinpoint regression models, and p values were calculated.ResultsA total of 23,674 lung cancer cases were enrolled. People in severely polluted cities were at higher risk for lung adenocarcinoma (p < 0.001). Most patients with lung adenocarcinoma had no history of lung-related diseases (p = 0.001). Anatomically, lung adenocarcinoma was more likely to occur in the right lung (p < 0.001). Non-manual labor workers were more likely to develop from lung adenocarcinoma than manual workers (p = 0.015). Notably, non-smokers were more likely to develop lung adenocarcinoma than smokers (p < 0.001). The proportion of lung adenocarcinoma increased significantly in Hebei Province (p < 0.001). Among non-smokers, the proportion of lung adenocarcinoma showed a higher rise than in smokers (p < 0.001).ConclusionsLung adenocarcinoma is the most common histological type of lung cancer in North China (Hebei Province), and the proportion of lung adenocarcinoma is increasing, especially among non-smokers. Lung adenocarcinoma is more common in women, severely polluted cities, individuals with no history of lung-related diseases, in the right lung, and in non-smokers. These can serve as a great guide in determining the accuracy of lung adenocarcinoma high-risk groups and lung cancer risk assessment models.https://www.frontiersin.org/articles/10.3389/fonc.2022.892571/fulllung adenocarcinomaepidemiologyrisk factorsnever-smokersNorth China |
| spellingShingle | Daojuan Li Jin Shi Xiaoping Dong Di Liang Jing Jin Yutong He Epidemiological characteristics and risk factors of lung adenocarcinoma: A retrospective observational study from North China Frontiers in Oncology lung adenocarcinoma epidemiology risk factors never-smokers North China |
| title | Epidemiological characteristics and risk factors of lung adenocarcinoma: A retrospective observational study from North China |
| title_full | Epidemiological characteristics and risk factors of lung adenocarcinoma: A retrospective observational study from North China |
| title_fullStr | Epidemiological characteristics and risk factors of lung adenocarcinoma: A retrospective observational study from North China |
| title_full_unstemmed | Epidemiological characteristics and risk factors of lung adenocarcinoma: A retrospective observational study from North China |
| title_short | Epidemiological characteristics and risk factors of lung adenocarcinoma: A retrospective observational study from North China |
| title_sort | epidemiological characteristics and risk factors of lung adenocarcinoma a retrospective observational study from north china |
| topic | lung adenocarcinoma epidemiology risk factors never-smokers North China |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.892571/full |
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