Strategies for enhancing cancer chemodynamic therapy performance
Abstract Chemodynamic therapy (CDT) has emerged to be a frontrunner amongst reactive oxygen species‐based cancer treatment modalities. CDT utilizes endogenous H2O2 in tumor microenvironment (TME) to produce cytotoxic hydroxyl radicals (•OH) via Fenton or Fenton‐like reactions. While possessing advan...
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| Format: | Article |
| Language: | English |
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Wiley
2022-04-01
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| Series: | Exploration |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/EXP.20210238 |
| _version_ | 1811242800358883328 |
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| author | Deblin Jana Yanli Zhao |
| author_facet | Deblin Jana Yanli Zhao |
| author_sort | Deblin Jana |
| collection | DOAJ |
| description | Abstract Chemodynamic therapy (CDT) has emerged to be a frontrunner amongst reactive oxygen species‐based cancer treatment modalities. CDT utilizes endogenous H2O2 in tumor microenvironment (TME) to produce cytotoxic hydroxyl radicals (•OH) via Fenton or Fenton‐like reactions. While possessing advantages such as tumor specificity, no need of external stimuli, and low side effects, practical applications of CDT are still impeded owing to the heterogeneity, complexity, and reductive environment of TME. Over the past couple of years, strategies to enhance CDT for efficient tumor regression are in rapid development in synergy with the growth of nanomedicine. In this review, we initially outline the fundamental understanding of Fenton and Fenton‐like reactions and their relationship with CDT. Subsequently, the development in the design of nanosystems for CDT is highlighted in a general manner. Furthermore, recent advancement of the strategies to augment Fenton reactions in TME for enhanced CDT is discussed in detail. Finally, perspectives toward the future development of CDT for better therapeutic outcome are presented. This review is expected to draw attention for collaborative research on CDT in the best interest of its future clinical applications. |
| first_indexed | 2024-04-12T13:56:26Z |
| format | Article |
| id | doaj.art-ed101a42d6e14a2aa9621ad4037f15fa |
| institution | Directory Open Access Journal |
| issn | 2766-8509 2766-2098 |
| language | English |
| last_indexed | 2024-04-12T13:56:26Z |
| publishDate | 2022-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Exploration |
| spelling | doaj.art-ed101a42d6e14a2aa9621ad4037f15fa2022-12-22T03:30:21ZengWileyExploration2766-85092766-20982022-04-0122n/an/a10.1002/EXP.20210238Strategies for enhancing cancer chemodynamic therapy performanceDeblin Jana0Yanli Zhao1Division of Chemistry and Biological Chemistry School of Physical and Mathematical Sciences Nanyang Technological University Singapore SingaporeDivision of Chemistry and Biological Chemistry School of Physical and Mathematical Sciences Nanyang Technological University Singapore SingaporeAbstract Chemodynamic therapy (CDT) has emerged to be a frontrunner amongst reactive oxygen species‐based cancer treatment modalities. CDT utilizes endogenous H2O2 in tumor microenvironment (TME) to produce cytotoxic hydroxyl radicals (•OH) via Fenton or Fenton‐like reactions. While possessing advantages such as tumor specificity, no need of external stimuli, and low side effects, practical applications of CDT are still impeded owing to the heterogeneity, complexity, and reductive environment of TME. Over the past couple of years, strategies to enhance CDT for efficient tumor regression are in rapid development in synergy with the growth of nanomedicine. In this review, we initially outline the fundamental understanding of Fenton and Fenton‐like reactions and their relationship with CDT. Subsequently, the development in the design of nanosystems for CDT is highlighted in a general manner. Furthermore, recent advancement of the strategies to augment Fenton reactions in TME for enhanced CDT is discussed in detail. Finally, perspectives toward the future development of CDT for better therapeutic outcome are presented. This review is expected to draw attention for collaborative research on CDT in the best interest of its future clinical applications.https://doi.org/10.1002/EXP.20210238chemodynamic therapiesFenton/Fenton‐like reactionsnanomaterialsreactive oxygen speciesstimuli |
| spellingShingle | Deblin Jana Yanli Zhao Strategies for enhancing cancer chemodynamic therapy performance Exploration chemodynamic therapies Fenton/Fenton‐like reactions nanomaterials reactive oxygen species stimuli |
| title | Strategies for enhancing cancer chemodynamic therapy performance |
| title_full | Strategies for enhancing cancer chemodynamic therapy performance |
| title_fullStr | Strategies for enhancing cancer chemodynamic therapy performance |
| title_full_unstemmed | Strategies for enhancing cancer chemodynamic therapy performance |
| title_short | Strategies for enhancing cancer chemodynamic therapy performance |
| title_sort | strategies for enhancing cancer chemodynamic therapy performance |
| topic | chemodynamic therapies Fenton/Fenton‐like reactions nanomaterials reactive oxygen species stimuli |
| url | https://doi.org/10.1002/EXP.20210238 |
| work_keys_str_mv | AT deblinjana strategiesforenhancingcancerchemodynamictherapyperformance AT yanlizhao strategiesforenhancingcancerchemodynamictherapyperformance |