The Metabolic Fingerprint of Doxorubicin-Induced Cardiotoxicity in Male CD-1 Mice Fades Away with Time While Autophagy Increases

The Metabolic Fingerprint of Doxorubicin-Induced Cardiotoxicity in Male CD-1 Mice Fades Away with Time While Autophagy Increases

The cardiotoxicity of doxorubicin (DOX) may manifest at the beginning/during treatment or years after, compromising patients’ quality of life. We intended to study the cardiac pathways one week (short-term, control 1 [CTRL1] and DOX1 groups) or five months (long-term, CTRL2 and DOX2 groups) after DO...

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Bibliographic Details
Main Authors: Sofia Reis Brandão, Ana Reis-Mendes, Maria João Neuparth, Félix Carvalho, Rita Ferreira, Vera Marisa Costa
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Pharmaceuticals
Subjects:
cardio-oncology
doxorubicin
energetic metabolism
apoptosis
autophagy
Online Access:https://www.mdpi.com/1424-8247/16/11/1613

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