What's in a Gene Pseudoexfoliation Syndrome and Pigment Dispersion Syndrome in the Same Patient
Pseudoexfoliation syndrome (PXS) and pigment dispersion syndrome (PDS) are two of the commonest disorders to produce secondary open-angle glaucoma through trabecular meshwork blockage. Each is a defined clinical entity, and while genetics likely play a significant role in the pathogenesis of both, t...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2016-01-01
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| Series: | Case Reports in Ophthalmology |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/443697 |
| _version_ | 1831726536028323840 |
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| author | Olya Pokrovskaya Colm O''Brien |
| author_facet | Olya Pokrovskaya Colm O''Brien |
| author_sort | Olya Pokrovskaya |
| collection | DOAJ |
| description | Pseudoexfoliation syndrome (PXS) and pigment dispersion syndrome (PDS) are two of the commonest disorders to produce secondary open-angle glaucoma through trabecular meshwork blockage. Each is a defined clinical entity, and while genetics likely play a significant role in the pathogenesis of both, the specific genes involved appear to be distinct. There is surprisingly little published in the literature regarding the coexistence of PDS and PXS in the same patient. We present the intriguing case of a patient who developed PDS in one eye and PXS in the other. This unusual case acts as a platform for an interesting discussion of the genomics of PXS and PDS. |
| first_indexed | 2024-12-21T06:11:12Z |
| format | Article |
| id | doaj.art-ed106a6178324a9eb10b959f004aee5b |
| institution | Directory Open Access Journal |
| issn | 1663-2699 |
| language | English |
| last_indexed | 2024-12-21T06:11:12Z |
| publishDate | 2016-01-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Ophthalmology |
| spelling | doaj.art-ed106a6178324a9eb10b959f004aee5b2022-12-21T19:13:32ZengKarger PublishersCase Reports in Ophthalmology1663-26992016-01-0171546010.1159/000443697443697What's in a Gene Pseudoexfoliation Syndrome and Pigment Dispersion Syndrome in the Same PatientOlya PokrovskayaColm O''BrienPseudoexfoliation syndrome (PXS) and pigment dispersion syndrome (PDS) are two of the commonest disorders to produce secondary open-angle glaucoma through trabecular meshwork blockage. Each is a defined clinical entity, and while genetics likely play a significant role in the pathogenesis of both, the specific genes involved appear to be distinct. There is surprisingly little published in the literature regarding the coexistence of PDS and PXS in the same patient. We present the intriguing case of a patient who developed PDS in one eye and PXS in the other. This unusual case acts as a platform for an interesting discussion of the genomics of PXS and PDS.http://www.karger.com/Article/FullText/443697PseudoexfoliationPigment dispersionGlaucomaLOXL1 |
| spellingShingle | Olya Pokrovskaya Colm O''Brien What's in a Gene Pseudoexfoliation Syndrome and Pigment Dispersion Syndrome in the Same Patient Case Reports in Ophthalmology Pseudoexfoliation Pigment dispersion Glaucoma LOXL1 |
| title | What's in a Gene Pseudoexfoliation Syndrome and Pigment Dispersion Syndrome in the Same Patient |
| title_full | What's in a Gene Pseudoexfoliation Syndrome and Pigment Dispersion Syndrome in the Same Patient |
| title_fullStr | What's in a Gene Pseudoexfoliation Syndrome and Pigment Dispersion Syndrome in the Same Patient |
| title_full_unstemmed | What's in a Gene Pseudoexfoliation Syndrome and Pigment Dispersion Syndrome in the Same Patient |
| title_short | What's in a Gene Pseudoexfoliation Syndrome and Pigment Dispersion Syndrome in the Same Patient |
| title_sort | what s in a gene pseudoexfoliation syndrome and pigment dispersion syndrome in the same patient |
| topic | Pseudoexfoliation Pigment dispersion Glaucoma LOXL1 |
| url | http://www.karger.com/Article/FullText/443697 |
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