Biological therapy in the treatment of moderate-to-severe ulcerative colitis patients: can colectomy be prevented?
Ulcerative colitis treatment intends to induce remission, and its maintenance. Biological drugs, such as infliximab, have been indicated in moderate and severe cases of the disease, which are unresponsive to conventional medication. Randomized controlled trials proved the efficacy of biological trea...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Thieme Revinter Publicações Ltda.
2011-12-01
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| Series: | Journal of Coloproctology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2237-93632011000400002 |
| _version_ | 1819008371781533696 |
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| author | Fábio Vieira Teixeira Rogério Saad Hossne Paulo Gustavo Kotze Rafael Denadai Sender Jankiel Miszputen |
| author_facet | Fábio Vieira Teixeira Rogério Saad Hossne Paulo Gustavo Kotze Rafael Denadai Sender Jankiel Miszputen |
| author_sort | Fábio Vieira Teixeira |
| collection | DOAJ |
| description | Ulcerative colitis treatment intends to induce remission, and its maintenance. Biological drugs, such as infliximab, have been indicated in moderate and severe cases of the disease, which are unresponsive to conventional medication. Randomized controlled trials proved the efficacy of biological treatment with high rates of sustained disease remission and mucosal healing. Recently, the concept of mucosal healing has been inversely associated with surgical treatment. Patients treated with infliximab have lower colectomy rates than those receiving conventional therapies. We suppose that earlier use of biological drugs in disease's course would lead to better clinical control and mucosal healing, with a consequent reduction in colectomy rates. To support this hypothesis, a literature review from January, 1996 to April, 2011 was performed.<br>O tratamento da colite ulcerativa tem como objetivo induzir a remissão, além da manutenção da remissão da doença. Agentes biológicos como o infliximabe têm sido indicados em casos moderados e graves da doença, os quais não respondem à medicação convencional. Ensaios clínicos randomizados comprovaram a eficácia do tratamento biológico com altas taxas de remissão da doença e cicatrização sustentada da mucosa. Recentemente, o conceito de cicatrização da mucosa tem sido inversamente associado com o tratamento cirúrgico. Pacientes tratados com infliximabe têm taxas mais baixas de colectomia se comparados com aqueles que receberam terapias convencionais. Supõe-se que quanto mais cedo for introduzida a terapia biológica no curso da doença, melhor seriam o controle clínico e a cicatrização da mucosa, com consequente redução nas taxas de colectomia. Para apoiar esta hipótese, foi realizada uma revisão da literatura entre janeiro de 1996 e abril de 2011. |
| first_indexed | 2024-12-21T00:39:25Z |
| format | Article |
| id | doaj.art-ed11ad1baa9c40af801d300ce8ef1c46 |
| institution | Directory Open Access Journal |
| issn | 2237-9363 |
| language | English |
| last_indexed | 2024-12-21T00:39:25Z |
| publishDate | 2011-12-01 |
| publisher | Thieme Revinter Publicações Ltda. |
| record_format | Article |
| series | Journal of Coloproctology |
| spelling | doaj.art-ed11ad1baa9c40af801d300ce8ef1c462022-12-21T19:21:44ZengThieme Revinter Publicações Ltda.Journal of Coloproctology2237-93632011-12-0131432532910.1590/S2237-93632011000400002Biological therapy in the treatment of moderate-to-severe ulcerative colitis patients: can colectomy be prevented?Fábio Vieira TeixeiraRogério Saad HossnePaulo Gustavo KotzeRafael DenadaiSender Jankiel MiszputenUlcerative colitis treatment intends to induce remission, and its maintenance. Biological drugs, such as infliximab, have been indicated in moderate and severe cases of the disease, which are unresponsive to conventional medication. Randomized controlled trials proved the efficacy of biological treatment with high rates of sustained disease remission and mucosal healing. Recently, the concept of mucosal healing has been inversely associated with surgical treatment. Patients treated with infliximab have lower colectomy rates than those receiving conventional therapies. We suppose that earlier use of biological drugs in disease's course would lead to better clinical control and mucosal healing, with a consequent reduction in colectomy rates. To support this hypothesis, a literature review from January, 1996 to April, 2011 was performed.<br>O tratamento da colite ulcerativa tem como objetivo induzir a remissão, além da manutenção da remissão da doença. Agentes biológicos como o infliximabe têm sido indicados em casos moderados e graves da doença, os quais não respondem à medicação convencional. Ensaios clínicos randomizados comprovaram a eficácia do tratamento biológico com altas taxas de remissão da doença e cicatrização sustentada da mucosa. Recentemente, o conceito de cicatrização da mucosa tem sido inversamente associado com o tratamento cirúrgico. Pacientes tratados com infliximabe têm taxas mais baixas de colectomia se comparados com aqueles que receberam terapias convencionais. Supõe-se que quanto mais cedo for introduzida a terapia biológica no curso da doença, melhor seriam o controle clínico e a cicatrização da mucosa, com consequente redução nas taxas de colectomia. Para apoiar esta hipótese, foi realizada uma revisão da literatura entre janeiro de 1996 e abril de 2011.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2237-93632011000400002terapia biológicacolectomiacolite ulcerativaresultado do tratamentobiological therapycolectomycolitis, ulcerativetreatment outcome |
| spellingShingle | Fábio Vieira Teixeira Rogério Saad Hossne Paulo Gustavo Kotze Rafael Denadai Sender Jankiel Miszputen Biological therapy in the treatment of moderate-to-severe ulcerative colitis patients: can colectomy be prevented? Journal of Coloproctology terapia biológica colectomia colite ulcerativa resultado do tratamento biological therapy colectomy colitis, ulcerative treatment outcome |
| title | Biological therapy in the treatment of moderate-to-severe ulcerative colitis patients: can colectomy be prevented? |
| title_full | Biological therapy in the treatment of moderate-to-severe ulcerative colitis patients: can colectomy be prevented? |
| title_fullStr | Biological therapy in the treatment of moderate-to-severe ulcerative colitis patients: can colectomy be prevented? |
| title_full_unstemmed | Biological therapy in the treatment of moderate-to-severe ulcerative colitis patients: can colectomy be prevented? |
| title_short | Biological therapy in the treatment of moderate-to-severe ulcerative colitis patients: can colectomy be prevented? |
| title_sort | biological therapy in the treatment of moderate to severe ulcerative colitis patients can colectomy be prevented |
| topic | terapia biológica colectomia colite ulcerativa resultado do tratamento biological therapy colectomy colitis, ulcerative treatment outcome |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2237-93632011000400002 |
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