Magnetization transfer imaging alterations and its diagnostic value in antipsychotic-naïve first-episode schizophrenia
Abstract Magnetization transfer imaging (MTI) may provide more sensitivity and mechanistic understanding of neuropathological changes associated with schizophrenia than volumetric MRI. This study aims to identify brain magnetization transfer ratio (MTR) changes in antipsychotic-naïve first-episode s...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2022-05-01
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| Series: | Translational Psychiatry |
| Online Access: | https://doi.org/10.1038/s41398-022-01939-5 |
| _version_ | 1811305855993249792 |
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| author | Du Lei Xueling Suo Kun Qin Walter H. L. Pinaya Yuan Ai Wenbin Li Weihong Kuang Su Lui Graham J. Kemp John A. Sweeney Qiyong Gong |
| author_facet | Du Lei Xueling Suo Kun Qin Walter H. L. Pinaya Yuan Ai Wenbin Li Weihong Kuang Su Lui Graham J. Kemp John A. Sweeney Qiyong Gong |
| author_sort | Du Lei |
| collection | DOAJ |
| description | Abstract Magnetization transfer imaging (MTI) may provide more sensitivity and mechanistic understanding of neuropathological changes associated with schizophrenia than volumetric MRI. This study aims to identify brain magnetization transfer ratio (MTR) changes in antipsychotic-naïve first-episode schizophrenia (FES), and to correlate MTR findings with clinical symptom severity. A total of 143 individuals with antipsychotic-naïve FES and 147 healthy controls (HCs) were included and underwent 3.0 T brain MTI between August 2005 and July 2014. Voxelwise analysis was performed to test for MTR differences with family-wise error corrections. Relationships of these differences to symptom severity were assessed using partial correlations. Exploratory analyses using a support vector machine (SVM) classifier were conducted to discriminate FES from HCs using MTR maps. Model performance was examined using a 10-fold stratified cross-validation. Compared with HCs, individuals with FES exhibited higher MTR values in left thalamus, precuneus, cuneus, and paracentral lobule, that were positively correlated with schizophrenia symptom severity [precuneus (r = 0.34, P = 0.0004), cuneus (r = 0.33, P = 0.0006) and paracentral lobule (r = 0.37, P = 0.001)]. Whole-brain MTR maps identified individuals with FES with overall accuracy 75.5% (219 of 290 individuals) based on SVM approach. In antipsychotic-naïve FES, clinically relevant biophysical abnormalities detected by MTI mainly in the left parieto-occipital regions are informative about local brain pathology, and have potential as diagnostic markers. |
| first_indexed | 2024-04-13T08:33:57Z |
| format | Article |
| id | doaj.art-ed12ba8743844d859e379593edc3b6eb |
| institution | Directory Open Access Journal |
| issn | 2158-3188 |
| language | English |
| last_indexed | 2024-04-13T08:33:57Z |
| publishDate | 2022-05-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Translational Psychiatry |
| spelling | doaj.art-ed12ba8743844d859e379593edc3b6eb2022-12-22T02:54:10ZengNature Publishing GroupTranslational Psychiatry2158-31882022-05-011211710.1038/s41398-022-01939-5Magnetization transfer imaging alterations and its diagnostic value in antipsychotic-naïve first-episode schizophreniaDu Lei0Xueling Suo1Kun Qin2Walter H. L. Pinaya3Yuan Ai4Wenbin Li5Weihong Kuang6Su Lui7Graham J. Kemp8John A. Sweeney9Qiyong Gong10Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan UniversityHuaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan UniversityHuaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan UniversityDepartment of Biomedical Engineering, School of Biomedical Engineering & Imaging Sciences, King’s College LondonHuaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan UniversityHuaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan UniversityDepartment of Psychiatry, West China Hospital of Sichuan UniversityHuaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan UniversityLiverpool Magnetic Resonance Imaging Centre (LiMRIC) and Institute of Life Course and Medical Sciences, University of LiverpoolHuaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan UniversityHuaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan UniversityAbstract Magnetization transfer imaging (MTI) may provide more sensitivity and mechanistic understanding of neuropathological changes associated with schizophrenia than volumetric MRI. This study aims to identify brain magnetization transfer ratio (MTR) changes in antipsychotic-naïve first-episode schizophrenia (FES), and to correlate MTR findings with clinical symptom severity. A total of 143 individuals with antipsychotic-naïve FES and 147 healthy controls (HCs) were included and underwent 3.0 T brain MTI between August 2005 and July 2014. Voxelwise analysis was performed to test for MTR differences with family-wise error corrections. Relationships of these differences to symptom severity were assessed using partial correlations. Exploratory analyses using a support vector machine (SVM) classifier were conducted to discriminate FES from HCs using MTR maps. Model performance was examined using a 10-fold stratified cross-validation. Compared with HCs, individuals with FES exhibited higher MTR values in left thalamus, precuneus, cuneus, and paracentral lobule, that were positively correlated with schizophrenia symptom severity [precuneus (r = 0.34, P = 0.0004), cuneus (r = 0.33, P = 0.0006) and paracentral lobule (r = 0.37, P = 0.001)]. Whole-brain MTR maps identified individuals with FES with overall accuracy 75.5% (219 of 290 individuals) based on SVM approach. In antipsychotic-naïve FES, clinically relevant biophysical abnormalities detected by MTI mainly in the left parieto-occipital regions are informative about local brain pathology, and have potential as diagnostic markers.https://doi.org/10.1038/s41398-022-01939-5 |
| spellingShingle | Du Lei Xueling Suo Kun Qin Walter H. L. Pinaya Yuan Ai Wenbin Li Weihong Kuang Su Lui Graham J. Kemp John A. Sweeney Qiyong Gong Magnetization transfer imaging alterations and its diagnostic value in antipsychotic-naïve first-episode schizophrenia Translational Psychiatry |
| title | Magnetization transfer imaging alterations and its diagnostic value in antipsychotic-naïve first-episode schizophrenia |
| title_full | Magnetization transfer imaging alterations and its diagnostic value in antipsychotic-naïve first-episode schizophrenia |
| title_fullStr | Magnetization transfer imaging alterations and its diagnostic value in antipsychotic-naïve first-episode schizophrenia |
| title_full_unstemmed | Magnetization transfer imaging alterations and its diagnostic value in antipsychotic-naïve first-episode schizophrenia |
| title_short | Magnetization transfer imaging alterations and its diagnostic value in antipsychotic-naïve first-episode schizophrenia |
| title_sort | magnetization transfer imaging alterations and its diagnostic value in antipsychotic naive first episode schizophrenia |
| url | https://doi.org/10.1038/s41398-022-01939-5 |
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