Probing milk extracellular vesicles for intestinal delivery of RNA therapies

Probing milk extracellular vesicles for intestinal delivery of RNA therapies

Abstract Background Oral delivery remains unattainable for nucleic acid therapies. Many nanoparticle-based drug delivery systems have been investigated for this, but most suffer from poor gut stability, poor mucus diffusion and/or inefficient epithelial uptake. Extracellular vesicles from bovine mil...

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Bibliographic Details
Main Authors: Yunyue Zhang, Mona Belaid, Xiang Luo, Armond Daci, Rinë Limani, Julia Mantaj, Matthias Zilbauer, Komal Nayak, Driton Vllasaliu
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Journal of Nanobiotechnology
Subjects:
Extracellular vesicles
Oral nucleic acid delivery
siRNA
Inflammatory bowel disease
Intestinal epithelium
Online Access:https://doi.org/10.1186/s12951-023-02173-x

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