Invasive meningococcal disease epidemiology and vaccination strategies in four Southern European countries: a review of the available data
Introduction Invasive meningococcal disease (IMD) is a major health concern which can be prevented through vaccination. Conjugate vaccines against serogroups A, C, W, and Y and two protein-based vaccines against serogroup B are currently available in the European Union. Areas covered We present epid...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-12-01
|
| Series: | Expert Review of Vaccines |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/14760584.2023.2225596 |
| _version_ | 1797680393374138368 |
|---|---|
| author | Irini Zografaki Marios Detsis Maria Del Amo Raffaella Iantomasi Ana Maia Eva Agostina Montuori Cristina Mendez |
| author_facet | Irini Zografaki Marios Detsis Maria Del Amo Raffaella Iantomasi Ana Maia Eva Agostina Montuori Cristina Mendez |
| author_sort | Irini Zografaki |
| collection | DOAJ |
| description | Introduction Invasive meningococcal disease (IMD) is a major health concern which can be prevented through vaccination. Conjugate vaccines against serogroups A, C, W, and Y and two protein-based vaccines against serogroup B are currently available in the European Union. Areas covered We present epidemiologic data for Italy, Portugal, Greece, and Spain using publicly available reports from national reference laboratories and national or regional immunization programs (1999–2019), aiming to confirm risk groups, and describe time trends in overall incidence and serogroup distribution, as well as impact of immunization. Analysis of circulating MenB isolates in terms of the surface factor H binding protein (fHbp) using PubMLST is discussed as fHbp represents an important MenB vaccine antigen. Predictions of potential reactivity of the two available MenB vaccines (MenB-fHbp and 4CMenB) with circulating MenB isolates are also provided as assessed using the recently developed MenDeVAR tool. Expert opinion Understanding dynamics of IMD and continued genomic surveillance are essential for evaluating vaccine effectiveness, but also prompting proactive immunization programs to prevent future outbreaks. Importantly, the successful design of further effective meningococcal vaccines to fight IMD relies on considering the unpredictable epidemiology of the disease and combining lessons learnt from capsule polysaccharide vaccines and protein-based vaccines. |
| first_indexed | 2024-03-11T23:29:21Z |
| format | Article |
| id | doaj.art-ed16696fb1aa41af89394560cd0c8369 |
| institution | Directory Open Access Journal |
| issn | 1476-0584 1744-8395 |
| language | English |
| last_indexed | 2024-03-11T23:29:21Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Expert Review of Vaccines |
| spelling | doaj.art-ed16696fb1aa41af89394560cd0c83692023-09-20T10:33:44ZengTaylor & Francis GroupExpert Review of Vaccines1476-05841744-83952023-12-0122154556210.1080/14760584.2023.22255962225596Invasive meningococcal disease epidemiology and vaccination strategies in four Southern European countries: a review of the available dataIrini Zografaki0Marios Detsis1Maria Del Amo2Raffaella Iantomasi3Ana Maia4Eva Agostina Montuori5Cristina Mendez6Pfizer GreecePfizer GreecePfizer SpainPfizer ItalyPfizer PortugalPfizer ItalyPfizer SpainIntroduction Invasive meningococcal disease (IMD) is a major health concern which can be prevented through vaccination. Conjugate vaccines against serogroups A, C, W, and Y and two protein-based vaccines against serogroup B are currently available in the European Union. Areas covered We present epidemiologic data for Italy, Portugal, Greece, and Spain using publicly available reports from national reference laboratories and national or regional immunization programs (1999–2019), aiming to confirm risk groups, and describe time trends in overall incidence and serogroup distribution, as well as impact of immunization. Analysis of circulating MenB isolates in terms of the surface factor H binding protein (fHbp) using PubMLST is discussed as fHbp represents an important MenB vaccine antigen. Predictions of potential reactivity of the two available MenB vaccines (MenB-fHbp and 4CMenB) with circulating MenB isolates are also provided as assessed using the recently developed MenDeVAR tool. Expert opinion Understanding dynamics of IMD and continued genomic surveillance are essential for evaluating vaccine effectiveness, but also prompting proactive immunization programs to prevent future outbreaks. Importantly, the successful design of further effective meningococcal vaccines to fight IMD relies on considering the unpredictable epidemiology of the disease and combining lessons learnt from capsule polysaccharide vaccines and protein-based vaccines.http://dx.doi.org/10.1080/14760584.2023.2225596factor h binding proteininvasive meningococcal diseasemendevarneisseria meningitidisserogroupsouthern europevaccine |
| spellingShingle | Irini Zografaki Marios Detsis Maria Del Amo Raffaella Iantomasi Ana Maia Eva Agostina Montuori Cristina Mendez Invasive meningococcal disease epidemiology and vaccination strategies in four Southern European countries: a review of the available data Expert Review of Vaccines factor h binding protein invasive meningococcal disease mendevar neisseria meningitidis serogroup southern europe vaccine |
| title | Invasive meningococcal disease epidemiology and vaccination strategies in four Southern European countries: a review of the available data |
| title_full | Invasive meningococcal disease epidemiology and vaccination strategies in four Southern European countries: a review of the available data |
| title_fullStr | Invasive meningococcal disease epidemiology and vaccination strategies in four Southern European countries: a review of the available data |
| title_full_unstemmed | Invasive meningococcal disease epidemiology and vaccination strategies in four Southern European countries: a review of the available data |
| title_short | Invasive meningococcal disease epidemiology and vaccination strategies in four Southern European countries: a review of the available data |
| title_sort | invasive meningococcal disease epidemiology and vaccination strategies in four southern european countries a review of the available data |
| topic | factor h binding protein invasive meningococcal disease mendevar neisseria meningitidis serogroup southern europe vaccine |
| url | http://dx.doi.org/10.1080/14760584.2023.2225596 |
| work_keys_str_mv | AT irinizografaki invasivemeningococcaldiseaseepidemiologyandvaccinationstrategiesinfoursoutherneuropeancountriesareviewoftheavailabledata AT mariosdetsis invasivemeningococcaldiseaseepidemiologyandvaccinationstrategiesinfoursoutherneuropeancountriesareviewoftheavailabledata AT mariadelamo invasivemeningococcaldiseaseepidemiologyandvaccinationstrategiesinfoursoutherneuropeancountriesareviewoftheavailabledata AT raffaellaiantomasi invasivemeningococcaldiseaseepidemiologyandvaccinationstrategiesinfoursoutherneuropeancountriesareviewoftheavailabledata AT anamaia invasivemeningococcaldiseaseepidemiologyandvaccinationstrategiesinfoursoutherneuropeancountriesareviewoftheavailabledata AT evaagostinamontuori invasivemeningococcaldiseaseepidemiologyandvaccinationstrategiesinfoursoutherneuropeancountriesareviewoftheavailabledata AT cristinamendez invasivemeningococcaldiseaseepidemiologyandvaccinationstrategiesinfoursoutherneuropeancountriesareviewoftheavailabledata |