Diabetic retinopathy is associated with the presence and burden of subclinical carotid atherosclerosis in type 1 diabetes
Abstract Background Cardiovascular (CV) disease due to atherosclerosis is a major cause of morbidity and mortality in adult patients with diabetes, either type 1 or type 2 diabetes. The aim of the study was to assess the association of the frequency and the burden of subclinical carotid atherosclero...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-05-01
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| Series: | Cardiovascular Diabetology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12933-018-0706-z |
| _version_ | 1819183139169239040 |
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| author | Marc Carbonell Esmeralda Castelblanco Xavier Valldeperas Àngels Betriu Alícia Traveset Minerva Granado-Casas Marta Hernández Federico Vázquez Mariona Martín Esther Rubinat Albert Lecube Josep Franch-Nadal Elvira Fernández Manel Puig-Domingo Angelo Avogaro Núria Alonso Dídac Mauricio |
| author_facet | Marc Carbonell Esmeralda Castelblanco Xavier Valldeperas Àngels Betriu Alícia Traveset Minerva Granado-Casas Marta Hernández Federico Vázquez Mariona Martín Esther Rubinat Albert Lecube Josep Franch-Nadal Elvira Fernández Manel Puig-Domingo Angelo Avogaro Núria Alonso Dídac Mauricio |
| author_sort | Marc Carbonell |
| collection | DOAJ |
| description | Abstract Background Cardiovascular (CV) disease due to atherosclerosis is a major cause of morbidity and mortality in adult patients with diabetes, either type 1 or type 2 diabetes. The aim of the study was to assess the association of the frequency and the burden of subclinical carotid atherosclerotic disease in patients with type 1 diabetes according to the presence and severity of diabetic retinopathy (DR). Methods A cross-sectional study was conducted in 340 patients with type 1 diabetes (41.5% with DR), and in 304 non-diabetic individuals. All participants were free from previous CV disease and chronic kidney disease (CKD). B-mode carotid ultrasound imaging was performed in all the study subjects. Patients with type 1 diabetes underwent a full eye examination, and DR patients were divided into two groups: mild disease and advanced disease. Results In the group of patients with type 1 diabetes, the percentage of patients with carotid plaques was higher in those with DR compared with those without DR (44.7% vs. 24.1%, p < 0.001). Patients with DR also presented a higher incidence of ≥ 2 carotid plaques (25.5% vs. 11.1%, p < 0.001). Apart from other traditional cardiovascular risk factors, the presence of advanced stages of DR was independently associated with the presence (p = 0.044) and the burden (≥ 2 carotid plaques; p = 0.009) of subclinical carotid atherosclerosis. Conclusions In patients with type 1 diabetes without previous CV disease or established CKD, the presence of advanced stages of DR is associated with a higher atherosclerotic burden in the carotid arteries. The presence of DR identifies patients at risk for carotid atherosclerotic disease. |
| first_indexed | 2024-12-22T22:57:16Z |
| format | Article |
| id | doaj.art-ed18c8423e1b414f89447d8c4a024a3e |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-12-22T22:57:16Z |
| publishDate | 2018-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-ed18c8423e1b414f89447d8c4a024a3e2022-12-21T18:09:47ZengBMCCardiovascular Diabetology1475-28402018-05-0117111010.1186/s12933-018-0706-zDiabetic retinopathy is associated with the presence and burden of subclinical carotid atherosclerosis in type 1 diabetesMarc Carbonell0Esmeralda Castelblanco1Xavier Valldeperas2Àngels Betriu3Alícia Traveset4Minerva Granado-Casas5Marta Hernández6Federico Vázquez7Mariona Martín8Esther Rubinat9Albert Lecube10Josep Franch-Nadal11Elvira Fernández12Manel Puig-Domingo13Angelo Avogaro14Núria Alonso15Dídac Mauricio16Department of Ophthalmology, University Hospital Germans Trias i PujolDepartment of Endocrinology and Nutrition, University Hospital and Health Science Research Institute Germans Trias i PujolDepartment of Ophthalmology, University Hospital Germans Trias i PujolBiomedical Research Institute of LleidaDepartment of Ophthalmology, University Hospital Arnau de VilanovaDepartment of Endocrinology and Nutrition, University Hospital and Health Science Research Institute Germans Trias i PujolBiomedical Research Institute of LleidaDepartment of Endocrinology and Nutrition, University Hospital and Health Science Research Institute Germans Trias i PujolDepartment of Endocrinology and Nutrition, University Hospital and Health Science Research Institute Germans Trias i PujolBiomedical Research Institute of LleidaBiomedical Research Institute of LleidaCenter for Biomedical Research on Diabetes and Associated Metabolic Diseases (CIBERDEM)Biomedical Research Institute of LleidaDepartment of Endocrinology and Nutrition, University Hospital and Health Science Research Institute Germans Trias i PujolDepartment of Medicine, University of PadovaDepartment of Endocrinology and Nutrition, University Hospital and Health Science Research Institute Germans Trias i PujolDepartment of Endocrinology and Nutrition, University Hospital and Health Science Research Institute Germans Trias i PujolAbstract Background Cardiovascular (CV) disease due to atherosclerosis is a major cause of morbidity and mortality in adult patients with diabetes, either type 1 or type 2 diabetes. The aim of the study was to assess the association of the frequency and the burden of subclinical carotid atherosclerotic disease in patients with type 1 diabetes according to the presence and severity of diabetic retinopathy (DR). Methods A cross-sectional study was conducted in 340 patients with type 1 diabetes (41.5% with DR), and in 304 non-diabetic individuals. All participants were free from previous CV disease and chronic kidney disease (CKD). B-mode carotid ultrasound imaging was performed in all the study subjects. Patients with type 1 diabetes underwent a full eye examination, and DR patients were divided into two groups: mild disease and advanced disease. Results In the group of patients with type 1 diabetes, the percentage of patients with carotid plaques was higher in those with DR compared with those without DR (44.7% vs. 24.1%, p < 0.001). Patients with DR also presented a higher incidence of ≥ 2 carotid plaques (25.5% vs. 11.1%, p < 0.001). Apart from other traditional cardiovascular risk factors, the presence of advanced stages of DR was independently associated with the presence (p = 0.044) and the burden (≥ 2 carotid plaques; p = 0.009) of subclinical carotid atherosclerosis. Conclusions In patients with type 1 diabetes without previous CV disease or established CKD, the presence of advanced stages of DR is associated with a higher atherosclerotic burden in the carotid arteries. The presence of DR identifies patients at risk for carotid atherosclerotic disease.http://link.springer.com/article/10.1186/s12933-018-0706-zType 1 diabetesRetinopathySubclinical carotid atherosclerosis |
| spellingShingle | Marc Carbonell Esmeralda Castelblanco Xavier Valldeperas Àngels Betriu Alícia Traveset Minerva Granado-Casas Marta Hernández Federico Vázquez Mariona Martín Esther Rubinat Albert Lecube Josep Franch-Nadal Elvira Fernández Manel Puig-Domingo Angelo Avogaro Núria Alonso Dídac Mauricio Diabetic retinopathy is associated with the presence and burden of subclinical carotid atherosclerosis in type 1 diabetes Cardiovascular Diabetology Type 1 diabetes Retinopathy Subclinical carotid atherosclerosis |
| title | Diabetic retinopathy is associated with the presence and burden of subclinical carotid atherosclerosis in type 1 diabetes |
| title_full | Diabetic retinopathy is associated with the presence and burden of subclinical carotid atherosclerosis in type 1 diabetes |
| title_fullStr | Diabetic retinopathy is associated with the presence and burden of subclinical carotid atherosclerosis in type 1 diabetes |
| title_full_unstemmed | Diabetic retinopathy is associated with the presence and burden of subclinical carotid atherosclerosis in type 1 diabetes |
| title_short | Diabetic retinopathy is associated with the presence and burden of subclinical carotid atherosclerosis in type 1 diabetes |
| title_sort | diabetic retinopathy is associated with the presence and burden of subclinical carotid atherosclerosis in type 1 diabetes |
| topic | Type 1 diabetes Retinopathy Subclinical carotid atherosclerosis |
| url | http://link.springer.com/article/10.1186/s12933-018-0706-z |
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