Human Tau Expression Does Not Induce Mouse Retina Neurodegeneration, Suggesting Differential Toxicity of Tau in Brain vs. Retinal Neurons

Human Tau Expression Does Not Induce Mouse Retina Neurodegeneration, Suggesting Differential Toxicity of Tau in Brain vs. Retinal Neurons

The implication of the microtubule-associated protein (MAP) Tau in the ocular manifestations of Alzheimer’s disease (AD) is elusive due to the lack of relevant animal model. However, signs of AD have been reported in the brain of transgenic mice expressing human Tau (hTau). To assess whether hTau is...

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Bibliographic Details
Main Authors: Léa Rodriguez, Julius Baya Mdzomba, Sandrine Joly, Mélissa Boudreau-Laprise, Emmanuel Planel, Vincent Pernet
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
human Tau
Alzheimer’s disease
retina
electroretinogram
photoreceptors
bipolar cells
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00293/full

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