Akt isoforms in the immune system
Akt is a PI3K-activated serine-threonine kinase that exists in three distinct isoforms. Akt’s expression in most immune cells, either at baseline or upon activation, reflects its importance in the immune system. While Akt is most highly expressed in innate immune cells, it plays crucial roles in bot...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.990874/full |
| _version_ | 1811339529755295744 |
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| author | Mireia Guerau-de-Arellano Mireia Guerau-de-Arellano Mireia Guerau-de-Arellano Mireia Guerau-de-Arellano Mireia Guerau-de-Arellano Zayda L. Piedra-Quintero Philip N. Tsichlis Philip N. Tsichlis |
| author_facet | Mireia Guerau-de-Arellano Mireia Guerau-de-Arellano Mireia Guerau-de-Arellano Mireia Guerau-de-Arellano Mireia Guerau-de-Arellano Zayda L. Piedra-Quintero Philip N. Tsichlis Philip N. Tsichlis |
| author_sort | Mireia Guerau-de-Arellano |
| collection | DOAJ |
| description | Akt is a PI3K-activated serine-threonine kinase that exists in three distinct isoforms. Akt’s expression in most immune cells, either at baseline or upon activation, reflects its importance in the immune system. While Akt is most highly expressed in innate immune cells, it plays crucial roles in both innate and adaptive immune cell development and/or effector functions. In this review, we explore what’s known about the role of Akt in innate and adaptive immune cells. Wherever possible, we discuss the overlapping and distinct role of the three Akt isoforms, namely Akt1, Akt2, and Akt3, in immune cells. |
| first_indexed | 2024-04-13T18:28:05Z |
| format | Article |
| id | doaj.art-ed1c0cae6a8e4117bb2d5e49302d3186 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T18:28:05Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-ed1c0cae6a8e4117bb2d5e49302d31862022-12-22T02:35:12ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-08-011310.3389/fimmu.2022.990874990874Akt isoforms in the immune systemMireia Guerau-de-Arellano0Mireia Guerau-de-Arellano1Mireia Guerau-de-Arellano2Mireia Guerau-de-Arellano3Mireia Guerau-de-Arellano4Zayda L. Piedra-Quintero5Philip N. Tsichlis6Philip N. Tsichlis7School of Health and Rehabilitation Sciences, Division of Medical Laboratory Science, College of Medicine, Wexner Medical Center, The Ohio State University, Columbus, OH, United StatesInstitute for Behavioral Medicine Research, The Ohio State University, Columbus, OH, United StatesDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, United StatesDepartment of Neuroscience, The Ohio State University, Columbus, OH, United StatesThe Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, OH, United StatesSchool of Health and Rehabilitation Sciences, Division of Medical Laboratory Science, College of Medicine, Wexner Medical Center, The Ohio State University, Columbus, OH, United StatesThe Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, OH, United StatesDepartment of Cancer Biology and Genetics, The Ohio State University, Columbus, OH, United StatesAkt is a PI3K-activated serine-threonine kinase that exists in three distinct isoforms. Akt’s expression in most immune cells, either at baseline or upon activation, reflects its importance in the immune system. While Akt is most highly expressed in innate immune cells, it plays crucial roles in both innate and adaptive immune cell development and/or effector functions. In this review, we explore what’s known about the role of Akt in innate and adaptive immune cells. Wherever possible, we discuss the overlapping and distinct role of the three Akt isoforms, namely Akt1, Akt2, and Akt3, in immune cells.https://www.frontiersin.org/articles/10.3389/fimmu.2022.990874/fullAktAkt1Akt2Akt3immune cells |
| spellingShingle | Mireia Guerau-de-Arellano Mireia Guerau-de-Arellano Mireia Guerau-de-Arellano Mireia Guerau-de-Arellano Mireia Guerau-de-Arellano Zayda L. Piedra-Quintero Philip N. Tsichlis Philip N. Tsichlis Akt isoforms in the immune system Frontiers in Immunology Akt Akt1 Akt2 Akt3 immune cells |
| title | Akt isoforms in the immune system |
| title_full | Akt isoforms in the immune system |
| title_fullStr | Akt isoforms in the immune system |
| title_full_unstemmed | Akt isoforms in the immune system |
| title_short | Akt isoforms in the immune system |
| title_sort | akt isoforms in the immune system |
| topic | Akt Akt1 Akt2 Akt3 immune cells |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.990874/full |
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