Hypoxic microenvironment induced spatial transcriptome changes in pancreatic cancer
Objective: Hypoxia is a significant feature of solid tumors, including pancreatic ductal adenocarcinoma (PDAC). It is associated with tumor invasion, metastasis, and drug resistance. However, the spatial distribution of hypoxia-related heterogeneity in PDAC remains unclear. Methods: Spatial transcri...
Main Authors: | Huizhi Sun, Danfang Zhang, Chongbiao Huang, Yuhong Guo, Zhao Yang, Nan Yao, Xueyi Dong, Runfen Cheng, Nan Zhao, Jie Meng, Baocun Sun, Jihui Hao |
---|---|
Format: | Article |
Language: | English |
Published: |
China Anti-Cancer Association
2021-05-01
|
Series: | Cancer Biology & Medicine |
Subjects: | |
Online Access: | http://www.cancerbiomed.org/index.php/cocr/article/view/1864 |
Similar Items
-
MIF promotes cell invasion by the LRP1-uPAR interaction in pancreatic cancer cells
by: Huizhi Sun, et al.
Published: (2023-01-01) -
ENO1 expression and Erk phosphorylation in PDAC and their effects on tumor cell apoptosis in a hypoxic microenvironment
by: Huizhi Sun, et al.
Published: (2022-11-01) -
The relevance between hypoxia-dependent spatial transcriptomics and the prognosis and efficacy of immunotherapy in claudin-low breast cancer
by: Huizhi Sun, et al.
Published: (2023-01-01) -
Spatial maps of hepatocellular carcinoma transcriptomes highlight an unexplored landscape of heterogeneity and a novel gene signature for survival
by: Nan Zhao, et al.
Published: (2022-02-01) -
Pancreatic Ductal Adenocarcinoma: The Characteristics of Contrast-Enhanced Ultrasound Are Correlated with the Hypoxic Microenvironment
by: Lan Wang, et al.
Published: (2023-10-01)