Cu-Catalyzed Arylation of Bromo-Difluoro-Acetamides by Aryl Boronic Acids, Aryl Trialkoxysilanes and Dimethyl-Aryl-Sulfonium Salts: New Entries to Aromatic Amides

Cu-Catalyzed Arylation of Bromo-Difluoro-Acetamides by Aryl Boronic Acids, Aryl Trialkoxysilanes and Dimethyl-Aryl-Sulfonium Salts: New Entries to Aromatic Amides

We describe a mechanism-guided discovery of a synthetic methodology that enables the preparation of aromatic amides from 2-bromo-2,2-difluoroacetamides utilizing a copper-catalyzed direct arylation. Readily available and structurally simple aryl precursors such as aryl boronic acids, aryl trialkoxys...

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Bibliographic Details
Main Authors: Satenik Mkrtchyan, Michał Jakubczyk, Suneel Lanka, Michael Pittelkow, Viktor O. Iaroshenko
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Molecules
Subjects:
fluorine
amides
copper
catalysis
C-C-coupling
boronic acids
Online Access:https://www.mdpi.com/1420-3049/26/10/2957

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