Bach2 Deficiency Leads to Spontaneous Expansion of IL-4-Producing T Follicular Helper Cells and Autoimmunity

Bach2 Deficiency Leads to Spontaneous Expansion of IL-4-Producing T Follicular Helper Cells and Autoimmunity

The transcription factor Bach2 is a susceptible gene for numerous autoimmune diseases including systemic lupus erythematosus (SLE). Bach2−/− mice can develop a lupus-like autoimmune disease. However, the exact cellular and molecular mechanisms via which Bach2 protects the hosts from developing autoi...

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Bibliographic Details
Main Authors: Heng Zhang, Qianwen Hu, Min Zhang, Fang Yang, Cheng Peng, Zhen Zhang, Chuanxin Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Immunology
Subjects:
Bach2
T follicular helper cells
IL-4
autoimmunity
BCL6
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02050/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.02050/full

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