Coinfection with Mycoplasma Pneumoniae and Chlamydia Pneumoniae in ruptured plaques associated with acute myocardial infarction
OBJECTIVE: To study atheromas, Mycoplasma pneumoniae (M. pneumoniae), and Chlamydia pneumoniae (C. pneumoniae). METHODS: C. pneumoniae was studied with immunohistochemistry and M. pneumoniae with in situ hybridization (ISH), in segments of coronary arteries (SCA) as follows: group A - thrombosed rup...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Cardiologia (SBC)
2003-07-01
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| Series: | Arquivos Brasileiros de Cardiologia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2003000900001 |
| _version_ | 1818531934297391104 |
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| author | Maria de Lourdes Higuchi Marcia Martins Reis Nádia Vieira Sambiase Suely Aparecida Pinheiro Palomino Jussara Bianchi Castelli Paulo Sampaio Gutierrez Vera Demarchi Aiello José Antonio Franchini Ramires |
| author_facet | Maria de Lourdes Higuchi Marcia Martins Reis Nádia Vieira Sambiase Suely Aparecida Pinheiro Palomino Jussara Bianchi Castelli Paulo Sampaio Gutierrez Vera Demarchi Aiello José Antonio Franchini Ramires |
| author_sort | Maria de Lourdes Higuchi |
| collection | DOAJ |
| description | OBJECTIVE: To study atheromas, Mycoplasma pneumoniae (M. pneumoniae), and Chlamydia pneumoniae (C. pneumoniae). METHODS: C. pneumoniae was studied with immunohistochemistry and M. pneumoniae with in situ hybridization (ISH), in segments of coronary arteries (SCA) as follows: group A - thrombosed ruptured plaques (TRP) of 23 patients who died due to acute myocardial infarction (AMI); group B - 23 nonruptured plaques (NRP) of group A patients; group C - NRP of 11 coronary patients who did not die due to AMI; and group D - 11 SCA from patients with dilated cardiomyopathy or Chagas' disease without atherosclerosis. RESULTS: The mean number of C. pneumoniae+ cells/400x in groups A, B, C, and D was, respectively, 3.3±3.6; 1.0±1.3; 1.2±2.4; and 0.4±0.3; and the percentage of M. pneumoniae area was, respectively, 3.9±3.5; 1.5± 1.6; 0.9±0.9; and 0.4±0.2. More M. pneumoniae and C. pneumoniae were found in of group A than in group B (P<0.01). Good correlation was seen between the area of the vessel and the M. pneumoniae area in the plaque (r = 0.46; P=0.001) and between C. pneumoniae+ cells and CD4+ T lymphocytes (r = 0.42; P<0.01). The number of C. pneumoniae+ cells correlated with CD20+ B cells (r=0.48; P<0.01). CONCLUSION: M. pneumoniae and C. pneumoniae are more frequently found in TRP correlate with the intensity of the inflammation and diameter of the vessel (positive remodeling). |
| first_indexed | 2024-12-11T17:38:57Z |
| format | Article |
| id | doaj.art-ed1ff23dceef45e6b0260f4e784f6385 |
| institution | Directory Open Access Journal |
| issn | 0066-782X 1678-4170 |
| language | English |
| last_indexed | 2024-12-11T17:38:57Z |
| publishDate | 2003-07-01 |
| publisher | Sociedade Brasileira de Cardiologia (SBC) |
| record_format | Article |
| series | Arquivos Brasileiros de Cardiologia |
| spelling | doaj.art-ed1ff23dceef45e6b0260f4e784f63852022-12-22T00:56:35ZengSociedade Brasileira de Cardiologia (SBC)Arquivos Brasileiros de Cardiologia0066-782X1678-41702003-07-01811122210.1590/S0066-782X2003000900001Coinfection with Mycoplasma Pneumoniae and Chlamydia Pneumoniae in ruptured plaques associated with acute myocardial infarctionMaria de Lourdes HiguchiMarcia Martins ReisNádia Vieira SambiaseSuely Aparecida Pinheiro PalominoJussara Bianchi CastelliPaulo Sampaio GutierrezVera Demarchi AielloJosé Antonio Franchini RamiresOBJECTIVE: To study atheromas, Mycoplasma pneumoniae (M. pneumoniae), and Chlamydia pneumoniae (C. pneumoniae). METHODS: C. pneumoniae was studied with immunohistochemistry and M. pneumoniae with in situ hybridization (ISH), in segments of coronary arteries (SCA) as follows: group A - thrombosed ruptured plaques (TRP) of 23 patients who died due to acute myocardial infarction (AMI); group B - 23 nonruptured plaques (NRP) of group A patients; group C - NRP of 11 coronary patients who did not die due to AMI; and group D - 11 SCA from patients with dilated cardiomyopathy or Chagas' disease without atherosclerosis. RESULTS: The mean number of C. pneumoniae+ cells/400x in groups A, B, C, and D was, respectively, 3.3±3.6; 1.0±1.3; 1.2±2.4; and 0.4±0.3; and the percentage of M. pneumoniae area was, respectively, 3.9±3.5; 1.5± 1.6; 0.9±0.9; and 0.4±0.2. More M. pneumoniae and C. pneumoniae were found in of group A than in group B (P<0.01). Good correlation was seen between the area of the vessel and the M. pneumoniae area in the plaque (r = 0.46; P=0.001) and between C. pneumoniae+ cells and CD4+ T lymphocytes (r = 0.42; P<0.01). The number of C. pneumoniae+ cells correlated with CD20+ B cells (r=0.48; P<0.01). CONCLUSION: M. pneumoniae and C. pneumoniae are more frequently found in TRP correlate with the intensity of the inflammation and diameter of the vessel (positive remodeling).http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2003000900001Mycoplasma pneumoniaeChlamydia pneumoniaeacute myocardial infarction |
| spellingShingle | Maria de Lourdes Higuchi Marcia Martins Reis Nádia Vieira Sambiase Suely Aparecida Pinheiro Palomino Jussara Bianchi Castelli Paulo Sampaio Gutierrez Vera Demarchi Aiello José Antonio Franchini Ramires Coinfection with Mycoplasma Pneumoniae and Chlamydia Pneumoniae in ruptured plaques associated with acute myocardial infarction Arquivos Brasileiros de Cardiologia Mycoplasma pneumoniae Chlamydia pneumoniae acute myocardial infarction |
| title | Coinfection with Mycoplasma Pneumoniae and Chlamydia Pneumoniae in ruptured plaques associated with acute myocardial infarction |
| title_full | Coinfection with Mycoplasma Pneumoniae and Chlamydia Pneumoniae in ruptured plaques associated with acute myocardial infarction |
| title_fullStr | Coinfection with Mycoplasma Pneumoniae and Chlamydia Pneumoniae in ruptured plaques associated with acute myocardial infarction |
| title_full_unstemmed | Coinfection with Mycoplasma Pneumoniae and Chlamydia Pneumoniae in ruptured plaques associated with acute myocardial infarction |
| title_short | Coinfection with Mycoplasma Pneumoniae and Chlamydia Pneumoniae in ruptured plaques associated with acute myocardial infarction |
| title_sort | coinfection with mycoplasma pneumoniae and chlamydia pneumoniae in ruptured plaques associated with acute myocardial infarction |
| topic | Mycoplasma pneumoniae Chlamydia pneumoniae acute myocardial infarction |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2003000900001 |
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