Positive and negative regulatory mechanisms for fine-tuning cellularity and functions of medullary thymic epithelial cells

Positive and negative regulatory mechanisms for fine-tuning cellularity and functions of medullary thymic epithelial cells

Self-tolerant T cells and regulatory T cells develop in the thymus. A wide variety of cell-cell interactions in the thymus is required for the differentiation, proliferation, and repertoire selection of T cells. Various secreted and cell surface molecules expressed in thymic epithelial cells mediate...

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Bibliographic Details
Main Authors: Taishin eAkiyama, Ryosuke eTateishi, Nobuko eAkiyama, Riko eYoshinaga, Tetsuya J. Kobayashi
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-09-01
Series:Frontiers in Immunology
Subjects:
T cells
mathematical modeling
autoimmune disease
Thymus
negative feedback
Medullary thymic epitheilal cells
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00461/full

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