Analysis of Dysferlin Direct Interactions with Putative Repair Proteins Links Apoptotic Signaling to Ca<sup>2+</sup> Elevation via PDCD6 and FKBP8

Analysis of Dysferlin Direct Interactions with Putative Repair Proteins Links Apoptotic Signaling to Ca<sup>2+</sup> Elevation via PDCD6 and FKBP8

Quantitative surface plasmon resonance (SPR) was utilized to determine binding strength and calcium dependence of direct interactions between dysferlin and proteins likely to mediate skeletal muscle repair, interrupted in limb girdle muscular dystrophy type 2B/R2. Dysferlin canonical C2A (cC2A) and...

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Bibliographic Details
Main Authors: Dennis G. Drescher, Marian J. Drescher, Dakshnamurthy Selvakumar, Neeraja P. Annam
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
calcium dependence
C2 domains
dysferlin
FKBP8
limb girdle muscular dystrophy type 2B/R2
PDCD6
Online Access:https://www.mdpi.com/1422-0067/24/5/4707

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