Premature Puberty and Thimerosal-Containing Hepatitis B Vaccination: A Case-Control Study in the Vaccine Safety Datalink
Studies suggest a relationship between exposure to endocrine disrupters, such as mercury (Hg), and premature puberty. Hg exposure from Thimerosal-containing hepatitis B vaccine, administered at specific intervals within the first six months of life, and the child’s long-term risk of being...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-11-01
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| Series: | Toxics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2305-6304/6/4/67 |
| _version_ | 1811240901352095744 |
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| author | David A. Geier Janet K. Kern Mark R. Geier |
| author_facet | David A. Geier Janet K. Kern Mark R. Geier |
| author_sort | David A. Geier |
| collection | DOAJ |
| description | Studies suggest a relationship between exposure to endocrine disrupters, such as mercury (Hg), and premature puberty. Hg exposure from Thimerosal-containing hepatitis B vaccine, administered at specific intervals within the first six months of life, and the child’s long-term risk of being diagnosed with premature puberty (ICD-9 code: 259.1), was retrospectively examined, using a hypothesis-testing, longitudinal case-control design on prospectively collected data, in the Vaccine Safety Datalink (VSD). Cases diagnosed with premature puberty were significantly more likely to have received increased exposure to Hg from hepatitis B vaccines preserved with Thimerosal given in the first month after birth (odds ratio (OR) = 1.803), first two months after birth (OR = 1.768), and first six months after birth (OR = 2.0955), compared to control subjects. When the data were separated by gender, the effects remained among females but not males. Female cases, as compared to female controls, were significantly more likely in a dose-dependent manner to have received a greater exposure to Hg from hepatitis B vaccines preserved with Thimerosal, given in the first six months after birth (OR = 1.0281 per µg Hg). The results of this study show a dose-dependent association between increasing organic Hg exposure from Thimerosal-containing hepatitis B vaccines administered within the first six months of life and the long-term risk of the child being diagnosed with premature puberty. |
| first_indexed | 2024-04-12T13:27:48Z |
| format | Article |
| id | doaj.art-ed270be3a199408b8817a663e3c7c772 |
| institution | Directory Open Access Journal |
| issn | 2305-6304 |
| language | English |
| last_indexed | 2024-04-12T13:27:48Z |
| publishDate | 2018-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj.art-ed270be3a199408b8817a663e3c7c7722022-12-22T03:31:16ZengMDPI AGToxics2305-63042018-11-01646710.3390/toxics6040067toxics6040067Premature Puberty and Thimerosal-Containing Hepatitis B Vaccination: A Case-Control Study in the Vaccine Safety DatalinkDavid A. Geier0Janet K. Kern1Mark R. Geier2Institute of Chronic Illnesses, Inc., 14 Redgate Court, Silver Spring, MD 20905, USAInstitute of Chronic Illnesses, Inc., 14 Redgate Court, Silver Spring, MD 20905, USAInstitute of Chronic Illnesses, Inc., 14 Redgate Court, Silver Spring, MD 20905, USAStudies suggest a relationship between exposure to endocrine disrupters, such as mercury (Hg), and premature puberty. Hg exposure from Thimerosal-containing hepatitis B vaccine, administered at specific intervals within the first six months of life, and the child’s long-term risk of being diagnosed with premature puberty (ICD-9 code: 259.1), was retrospectively examined, using a hypothesis-testing, longitudinal case-control design on prospectively collected data, in the Vaccine Safety Datalink (VSD). Cases diagnosed with premature puberty were significantly more likely to have received increased exposure to Hg from hepatitis B vaccines preserved with Thimerosal given in the first month after birth (odds ratio (OR) = 1.803), first two months after birth (OR = 1.768), and first six months after birth (OR = 2.0955), compared to control subjects. When the data were separated by gender, the effects remained among females but not males. Female cases, as compared to female controls, were significantly more likely in a dose-dependent manner to have received a greater exposure to Hg from hepatitis B vaccines preserved with Thimerosal, given in the first six months after birth (OR = 1.0281 per µg Hg). The results of this study show a dose-dependent association between increasing organic Hg exposure from Thimerosal-containing hepatitis B vaccines administered within the first six months of life and the long-term risk of the child being diagnosed with premature puberty.https://www.mdpi.com/2305-6304/6/4/67ethylmercurymercurymerthiolatepremature pubertythiomersal |
| spellingShingle | David A. Geier Janet K. Kern Mark R. Geier Premature Puberty and Thimerosal-Containing Hepatitis B Vaccination: A Case-Control Study in the Vaccine Safety Datalink Toxics ethylmercury mercury merthiolate premature puberty thiomersal |
| title | Premature Puberty and Thimerosal-Containing Hepatitis B Vaccination: A Case-Control Study in the Vaccine Safety Datalink |
| title_full | Premature Puberty and Thimerosal-Containing Hepatitis B Vaccination: A Case-Control Study in the Vaccine Safety Datalink |
| title_fullStr | Premature Puberty and Thimerosal-Containing Hepatitis B Vaccination: A Case-Control Study in the Vaccine Safety Datalink |
| title_full_unstemmed | Premature Puberty and Thimerosal-Containing Hepatitis B Vaccination: A Case-Control Study in the Vaccine Safety Datalink |
| title_short | Premature Puberty and Thimerosal-Containing Hepatitis B Vaccination: A Case-Control Study in the Vaccine Safety Datalink |
| title_sort | premature puberty and thimerosal containing hepatitis b vaccination a case control study in the vaccine safety datalink |
| topic | ethylmercury mercury merthiolate premature puberty thiomersal |
| url | https://www.mdpi.com/2305-6304/6/4/67 |
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