Association of serum leptin and ghrelin levels with smoking status on body weight: a systematic review and meta-analysis
Background and aimsSmoking cigarettes is a major global health problem that affects appetite and weight. The aim of this systematic review was to determine how smoking affected plasma leptin and ghrelin levels.MethodsA comprehensive search of PubMed, Scopus, Web of Science, and Ovid was conducted us...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1296764/full |
| _version_ | 1797405277100703744 |
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| author | Nour Shaheen Ahmed Shaheen Rehab Adel Diab Abdelrahman M. Saad Omar Ahmed Abdelwahab Sama Soliman Mahmoud Tarek Hefnawy Alaa Ramadan Mostafa Meshref Abdulqadir J. Nashwan |
| author_facet | Nour Shaheen Ahmed Shaheen Rehab Adel Diab Abdelrahman M. Saad Omar Ahmed Abdelwahab Sama Soliman Mahmoud Tarek Hefnawy Alaa Ramadan Mostafa Meshref Abdulqadir J. Nashwan |
| author_sort | Nour Shaheen |
| collection | DOAJ |
| description | Background and aimsSmoking cigarettes is a major global health problem that affects appetite and weight. The aim of this systematic review was to determine how smoking affected plasma leptin and ghrelin levels.MethodsA comprehensive search of PubMed, Scopus, Web of Science, and Ovid was conducted using a well-established methodology to gather all related publications.ResultsA total of 40 studies were included in the analysis of 11,336 patients. The overall effect showed a with a mean difference (MD) of −1.92[95%CI; −2.63: −1.20] and p = 0.00001. Subgroup analysis by study design revealed significant differences as well, but with high heterogeneity within the subgroups (I2 of 82.3%). Subgroup by sex showed that there was a significant difference in mean difference between the smoking and non-smoking groups for males (MD = −5.75[95% CI; −8.73: −2.77], p = 0.0002) but not for females (MD = −3.04[95% CI; −6.6:0.54], p = 0.10). Healthy, pregnant, diabetic and CVD subgroups found significant differences in the healthy (MD = −1.74[95% CI; −03.13: −0.35], p = 0.01) and diabetic (MD = −7.69[95% CI, −1.64: −0.73], p = 0.03). subgroups, but not in the pregnant or cardiovascular disease subgroups. On the other hand, the meta-analysis found no statistically significant difference in Ghrelin serum concentration between smokers and non-smokers (MD = 0.52[95% CI, −0.60:1.63], p = 0.36) and observed heterogeneity in the studies (I2 = 68%).ConclusionThis study demonstrates a correlation between smoking and serum leptin/ghrelin levels, which explains smoking’s effect on body weight.Systematic review registrationhttps://www.crd.york.ac.uk/ prospero/display_record.php, identifier (Record ID=326680). |
| first_indexed | 2024-03-09T03:07:29Z |
| format | Article |
| id | doaj.art-ed293ab6716b4eb5b64b54a4c3f036ad |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-03-09T03:07:29Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-ed293ab6716b4eb5b64b54a4c3f036ad2023-12-04T06:10:26ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402023-12-011410.3389/fpsyt.2023.12967641296764Association of serum leptin and ghrelin levels with smoking status on body weight: a systematic review and meta-analysisNour Shaheen0Ahmed Shaheen1Rehab Adel Diab2Abdelrahman M. Saad3Omar Ahmed Abdelwahab4Sama Soliman5Mahmoud Tarek Hefnawy6Alaa Ramadan7Mostafa Meshref8Abdulqadir J. Nashwan9Alexandria Faculty of Medicine, Alexandria University, Alexandria, EgyptAlexandria Faculty of Medicine, Alexandria University, Alexandria, EgyptFaculty of Medicine, Al-Azhar University, Medical Research Group of Egypt, Cairo, EgyptAlexandria Faculty of Medicine, Alexandria University, Alexandria, EgyptFaculty of Medicine, Al-Azhar University, Medical Research Group of Egypt, Cairo, EgyptFaculty of Medicine, The Pavlov First State Medical University of St. Petersburg, St. Petersburg, RussiaFaculty of Medicine, Zagazig University, Medical Research Group of Egypt, Cairo, EgyptFaculty of Medicine, South Valley University, Qena, EgyptNeurology Department, Faculty of Medicine, Al-Azhar University, Cairo, EgyptNursing Department, Hamad Medical Corporation, Doha, QatarBackground and aimsSmoking cigarettes is a major global health problem that affects appetite and weight. The aim of this systematic review was to determine how smoking affected plasma leptin and ghrelin levels.MethodsA comprehensive search of PubMed, Scopus, Web of Science, and Ovid was conducted using a well-established methodology to gather all related publications.ResultsA total of 40 studies were included in the analysis of 11,336 patients. The overall effect showed a with a mean difference (MD) of −1.92[95%CI; −2.63: −1.20] and p = 0.00001. Subgroup analysis by study design revealed significant differences as well, but with high heterogeneity within the subgroups (I2 of 82.3%). Subgroup by sex showed that there was a significant difference in mean difference between the smoking and non-smoking groups for males (MD = −5.75[95% CI; −8.73: −2.77], p = 0.0002) but not for females (MD = −3.04[95% CI; −6.6:0.54], p = 0.10). Healthy, pregnant, diabetic and CVD subgroups found significant differences in the healthy (MD = −1.74[95% CI; −03.13: −0.35], p = 0.01) and diabetic (MD = −7.69[95% CI, −1.64: −0.73], p = 0.03). subgroups, but not in the pregnant or cardiovascular disease subgroups. On the other hand, the meta-analysis found no statistically significant difference in Ghrelin serum concentration between smokers and non-smokers (MD = 0.52[95% CI, −0.60:1.63], p = 0.36) and observed heterogeneity in the studies (I2 = 68%).ConclusionThis study demonstrates a correlation between smoking and serum leptin/ghrelin levels, which explains smoking’s effect on body weight.Systematic review registrationhttps://www.crd.york.ac.uk/ prospero/display_record.php, identifier (Record ID=326680).https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1296764/fullsmokingleptinghrelinobesitycigarette smoking |
| spellingShingle | Nour Shaheen Ahmed Shaheen Rehab Adel Diab Abdelrahman M. Saad Omar Ahmed Abdelwahab Sama Soliman Mahmoud Tarek Hefnawy Alaa Ramadan Mostafa Meshref Abdulqadir J. Nashwan Association of serum leptin and ghrelin levels with smoking status on body weight: a systematic review and meta-analysis Frontiers in Psychiatry smoking leptin ghrelin obesity cigarette smoking |
| title | Association of serum leptin and ghrelin levels with smoking status on body weight: a systematic review and meta-analysis |
| title_full | Association of serum leptin and ghrelin levels with smoking status on body weight: a systematic review and meta-analysis |
| title_fullStr | Association of serum leptin and ghrelin levels with smoking status on body weight: a systematic review and meta-analysis |
| title_full_unstemmed | Association of serum leptin and ghrelin levels with smoking status on body weight: a systematic review and meta-analysis |
| title_short | Association of serum leptin and ghrelin levels with smoking status on body weight: a systematic review and meta-analysis |
| title_sort | association of serum leptin and ghrelin levels with smoking status on body weight a systematic review and meta analysis |
| topic | smoking leptin ghrelin obesity cigarette smoking |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1296764/full |
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