Hippocampus-retrosplenial cortex interaction is increased during phasic REM and contributes to memory consolidation
Abstract Hippocampal (HPC) theta oscillation during post-training rapid eye movement (REM) sleep supports spatial learning. Theta also modulates neuronal and oscillatory activity in the retrosplenial cortex (RSC) during REM sleep. To investigate the relevance of theta-driven interaction between thes...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-06-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-91659-5 |
| _version_ | 1818844990898438144 |
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| author | Daniel Gomes de Almeida-Filho Bruna Del Vechio Koike Francesca Billwiller Kelly Soares Farias Igor Rafael Praxedes de Sales Pierre-Hervé Luppi Sidarta Ribeiro Claudio Marcos Queiroz |
| author_facet | Daniel Gomes de Almeida-Filho Bruna Del Vechio Koike Francesca Billwiller Kelly Soares Farias Igor Rafael Praxedes de Sales Pierre-Hervé Luppi Sidarta Ribeiro Claudio Marcos Queiroz |
| author_sort | Daniel Gomes de Almeida-Filho |
| collection | DOAJ |
| description | Abstract Hippocampal (HPC) theta oscillation during post-training rapid eye movement (REM) sleep supports spatial learning. Theta also modulates neuronal and oscillatory activity in the retrosplenial cortex (RSC) during REM sleep. To investigate the relevance of theta-driven interaction between these two regions to memory consolidation, we computed the Granger causality within theta range on electrophysiological data recorded in freely behaving rats during REM sleep, both before and after contextual fear conditioning. We found a training-induced modulation of causality between HPC and RSC that was correlated with memory retrieval 24 h later. Retrieval was proportional to the change in the relative influence RSC exerted upon HPC theta oscillation. Importantly, causality peaked during theta acceleration, in synchrony with phasic REM sleep. Altogether, these results support a role for phasic REM sleep in hippocampo-cortical memory consolidation and suggest that causality modulation between RSC and HPC during REM sleep plays a functional role in that phenomenon. |
| first_indexed | 2024-12-19T05:22:33Z |
| format | Article |
| id | doaj.art-ed298cbeaf4e4392add1a42be5f98fa9 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-19T05:22:33Z |
| publishDate | 2021-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-ed298cbeaf4e4392add1a42be5f98fa92022-12-21T20:34:28ZengNature PortfolioScientific Reports2045-23222021-06-0111111410.1038/s41598-021-91659-5Hippocampus-retrosplenial cortex interaction is increased during phasic REM and contributes to memory consolidationDaniel Gomes de Almeida-Filho0Bruna Del Vechio Koike1Francesca Billwiller2Kelly Soares Farias3Igor Rafael Praxedes de Sales4Pierre-Hervé Luppi5Sidarta Ribeiro6Claudio Marcos Queiroz7Brain Institute, Federal University of Rio Grande do NorteBrain Institute, Federal University of Rio Grande do NorteUMR 5292 CNRS/U1028 INSERM, Center of Research in Neuroscience of Lyon, SLEEP Team, Université Claude Bernard Lyon I, Faculté de Médecine RTH LaennecBrain Institute, Federal University of Rio Grande do NorteBrain Institute, Federal University of Rio Grande do NorteUMR 5292 CNRS/U1028 INSERM, Center of Research in Neuroscience of Lyon, SLEEP Team, Université Claude Bernard Lyon I, Faculté de Médecine RTH LaennecBrain Institute, Federal University of Rio Grande do NorteBrain Institute, Federal University of Rio Grande do NorteAbstract Hippocampal (HPC) theta oscillation during post-training rapid eye movement (REM) sleep supports spatial learning. Theta also modulates neuronal and oscillatory activity in the retrosplenial cortex (RSC) during REM sleep. To investigate the relevance of theta-driven interaction between these two regions to memory consolidation, we computed the Granger causality within theta range on electrophysiological data recorded in freely behaving rats during REM sleep, both before and after contextual fear conditioning. We found a training-induced modulation of causality between HPC and RSC that was correlated with memory retrieval 24 h later. Retrieval was proportional to the change in the relative influence RSC exerted upon HPC theta oscillation. Importantly, causality peaked during theta acceleration, in synchrony with phasic REM sleep. Altogether, these results support a role for phasic REM sleep in hippocampo-cortical memory consolidation and suggest that causality modulation between RSC and HPC during REM sleep plays a functional role in that phenomenon.https://doi.org/10.1038/s41598-021-91659-5 |
| spellingShingle | Daniel Gomes de Almeida-Filho Bruna Del Vechio Koike Francesca Billwiller Kelly Soares Farias Igor Rafael Praxedes de Sales Pierre-Hervé Luppi Sidarta Ribeiro Claudio Marcos Queiroz Hippocampus-retrosplenial cortex interaction is increased during phasic REM and contributes to memory consolidation Scientific Reports |
| title | Hippocampus-retrosplenial cortex interaction is increased during phasic REM and contributes to memory consolidation |
| title_full | Hippocampus-retrosplenial cortex interaction is increased during phasic REM and contributes to memory consolidation |
| title_fullStr | Hippocampus-retrosplenial cortex interaction is increased during phasic REM and contributes to memory consolidation |
| title_full_unstemmed | Hippocampus-retrosplenial cortex interaction is increased during phasic REM and contributes to memory consolidation |
| title_short | Hippocampus-retrosplenial cortex interaction is increased during phasic REM and contributes to memory consolidation |
| title_sort | hippocampus retrosplenial cortex interaction is increased during phasic rem and contributes to memory consolidation |
| url | https://doi.org/10.1038/s41598-021-91659-5 |
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