Comparative effects of parsley leaves aqueous extract and ramipril on gentamicin induced nephrotoxicity in rats
BACKGROUND & OBJECTIVE: Rats are commonly used in experimental studies as they have a smaller body size, they are easily available, and their genetic profiles are similar to each other as compared to humans. Kidney pathologies are the result of an imbalance between reactive oxygen species and a...
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| Format: | Article |
| Language: | English |
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University of Faisalabad
2022-11-01
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| Series: | Journal of University Medical & Dental College |
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| Online Access: | https://www.jumdc.com/index.php/jumdc/article/view/729 |
| _version_ | 1811189109730836480 |
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| author | Eisha Akram Akbar Waheed Rukhsana Munawar Sidra Mumal Abdul Azeem |
| author_facet | Eisha Akram Akbar Waheed Rukhsana Munawar Sidra Mumal Abdul Azeem |
| author_sort | Eisha Akram |
| collection | DOAJ |
| description |
BACKGROUND & OBJECTIVE: Rats are commonly used in experimental studies as they have a smaller body size, they are easily available, and their genetic profiles are similar to each other as compared to humans. Kidney pathologies are the result of an imbalance between reactive oxygen species and antioxidants. Parsley aqueous extract is rich in polyphenolic contents and has nephroprotective effects. The objective of this study is to observe the effects of ramipril and parsley leaves aqueous extract in gentamicin induced nephrotoxicity.
METHODOLOGY: An Experimental study consisting of 40 healthy male albino rats were randomly distributed into two categories after taking samples for baseline values of urea and creatinine: Category 1 consisted of a control group (Group 1) having 10 rats, while category 2 comprised of 30 rats, divided into three experimental groups after being given intraperitoneal injections of gentamicin (80mg/kg) per day. Group 2 was taken as disease control, while group 3 and group 4 were parsley treated and ramipril treated for 28 days, respectively. Biochemical markers (serum urea and creatinine) were done at day 35. SPSS version 22 was applied for Statistical analysis. One-way ANOVA test was used to determine any difference in mean values. Post hoc tuckeys test was applied for multiple comparisons amongst groups. p<0.05 was measured as significant.
RESULTS: The treatment decreased the levels of serum urea and creatinine in nephrotoxic rats in group 3 (parsley treated group) and group 4 (ramipril treated group) in comparison to group 2. Group 3 had significantly reduced biochemical markers (p<0.05).
CONCLUSION: Parsley leaves extract significantly reduced the serum urea and creatinine levels as compared to ramipril.
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| first_indexed | 2024-04-11T14:30:24Z |
| format | Article |
| id | doaj.art-ed2bdc7dff194776a97d43ee0f0e2ad7 |
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| issn | 2221-7827 2310-5542 |
| language | English |
| last_indexed | 2024-04-11T14:30:24Z |
| publishDate | 2022-11-01 |
| publisher | University of Faisalabad |
| record_format | Article |
| series | Journal of University Medical & Dental College |
| spelling | doaj.art-ed2bdc7dff194776a97d43ee0f0e2ad72022-12-22T04:18:41ZengUniversity of FaisalabadJournal of University Medical & Dental College2221-78272310-55422022-11-0113410.37723/jumdc.v13i4.729Comparative effects of parsley leaves aqueous extract and ramipril on gentamicin induced nephrotoxicity in ratsEisha Akram0Akbar Waheed1Rukhsana Munawar2 Sidra Mumal3Abdul Azeem4Senior lecturer, Department of Pharmacology, Watim Medical and Dental College.Professor and Head Department of Pharmacology, Islamic International Medical College, Rawalpindi.Assistant Professor, Department of Pharmacology, Poonch Medical College, Rawalakot, Azad Jamu Kashmir.Assistant Professor, Department of Pharmacology, Islamic International Medical College, Rawalpindi.Assistant Professor, Department of Pharmacology, Watim Medical and Dental College. BACKGROUND & OBJECTIVE: Rats are commonly used in experimental studies as they have a smaller body size, they are easily available, and their genetic profiles are similar to each other as compared to humans. Kidney pathologies are the result of an imbalance between reactive oxygen species and antioxidants. Parsley aqueous extract is rich in polyphenolic contents and has nephroprotective effects. The objective of this study is to observe the effects of ramipril and parsley leaves aqueous extract in gentamicin induced nephrotoxicity. METHODOLOGY: An Experimental study consisting of 40 healthy male albino rats were randomly distributed into two categories after taking samples for baseline values of urea and creatinine: Category 1 consisted of a control group (Group 1) having 10 rats, while category 2 comprised of 30 rats, divided into three experimental groups after being given intraperitoneal injections of gentamicin (80mg/kg) per day. Group 2 was taken as disease control, while group 3 and group 4 were parsley treated and ramipril treated for 28 days, respectively. Biochemical markers (serum urea and creatinine) were done at day 35. SPSS version 22 was applied for Statistical analysis. One-way ANOVA test was used to determine any difference in mean values. Post hoc tuckeys test was applied for multiple comparisons amongst groups. p<0.05 was measured as significant. RESULTS: The treatment decreased the levels of serum urea and creatinine in nephrotoxic rats in group 3 (parsley treated group) and group 4 (ramipril treated group) in comparison to group 2. Group 3 had significantly reduced biochemical markers (p<0.05). CONCLUSION: Parsley leaves extract significantly reduced the serum urea and creatinine levels as compared to ramipril. https://www.jumdc.com/index.php/jumdc/article/view/729ParsleyAntioxidantRamiprilGentamicinSerum UreaSerum Creatinine |
| spellingShingle | Eisha Akram Akbar Waheed Rukhsana Munawar Sidra Mumal Abdul Azeem Comparative effects of parsley leaves aqueous extract and ramipril on gentamicin induced nephrotoxicity in rats Journal of University Medical & Dental College Parsley Antioxidant Ramipril Gentamicin Serum Urea Serum Creatinine |
| title | Comparative effects of parsley leaves aqueous extract and ramipril on gentamicin induced nephrotoxicity in rats |
| title_full | Comparative effects of parsley leaves aqueous extract and ramipril on gentamicin induced nephrotoxicity in rats |
| title_fullStr | Comparative effects of parsley leaves aqueous extract and ramipril on gentamicin induced nephrotoxicity in rats |
| title_full_unstemmed | Comparative effects of parsley leaves aqueous extract and ramipril on gentamicin induced nephrotoxicity in rats |
| title_short | Comparative effects of parsley leaves aqueous extract and ramipril on gentamicin induced nephrotoxicity in rats |
| title_sort | comparative effects of parsley leaves aqueous extract and ramipril on gentamicin induced nephrotoxicity in rats |
| topic | Parsley Antioxidant Ramipril Gentamicin Serum Urea Serum Creatinine |
| url | https://www.jumdc.com/index.php/jumdc/article/view/729 |
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