The PRotective Effect of Maternal Immunisation on preTerm birth: characterising the Underlying mechanisms and Role in newborn immune function: the PREMITUR study protocol
Maternal immunisation, a low cost and high efficacy intervention is recommended for its pathogen specific protection. Evidence suggests that maternal immunisation has another significant impact: reduction of preterm birth (PTB), the single greatest cause of childhood morbidity and mortality globally...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1212320/full |
| _version_ | 1797380580218765312 |
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| author | Michelle L. Giles Michelle L. Giles Michelle L. Giles Stephen Cole Jessica O’Bryan Sushena Krishnaswamy Sushena Krishnaswamy Rym Ben-Othman Nelly Amenyogbe Mary-Ann Davey Tobias Kollmann |
| author_facet | Michelle L. Giles Michelle L. Giles Michelle L. Giles Stephen Cole Jessica O’Bryan Sushena Krishnaswamy Sushena Krishnaswamy Rym Ben-Othman Nelly Amenyogbe Mary-Ann Davey Tobias Kollmann |
| author_sort | Michelle L. Giles |
| collection | DOAJ |
| description | Maternal immunisation, a low cost and high efficacy intervention is recommended for its pathogen specific protection. Evidence suggests that maternal immunisation has another significant impact: reduction of preterm birth (PTB), the single greatest cause of childhood morbidity and mortality globally. Our overarching question is: how does maternal immunisation modify the immune system in pregnant women and/or their newborn to reduce adverse pregnancy outcomes and enhance the newborn infant’s capacity to protect itself from infectious diseases during early childhood? To answer this question we are conducting a multi-site, prospective observational cohort study collecting maternal and infant biological samples at defined time points during pregnancy and post-partum from nulliparous women. We aim to enrol 400 women and determine the immune trajectory in pregnancy and the impact of maternal immunisation (including influenza, pertussis and/or COVID-19 vaccines) on this trajectory. The results are expected to identify areas that can be targeted for future intervention studies. |
| first_indexed | 2024-03-08T20:40:20Z |
| format | Article |
| id | doaj.art-ed2c581ae14a4ed0a15224ab69b757d1 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-08T20:40:20Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-ed2c581ae14a4ed0a15224ab69b757d12023-12-22T14:16:54ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-12-011410.3389/fimmu.2023.12123201212320The PRotective Effect of Maternal Immunisation on preTerm birth: characterising the Underlying mechanisms and Role in newborn immune function: the PREMITUR study protocolMichelle L. Giles0Michelle L. Giles1Michelle L. Giles2Stephen Cole3Jessica O’Bryan4Sushena Krishnaswamy5Sushena Krishnaswamy6Rym Ben-Othman7Nelly Amenyogbe8Mary-Ann Davey9Tobias Kollmann10Department of Obstetrics and Gynaecology, Monash University, Melbourne, VIC, AustraliaDepartment of Infectious Diseases, University of Melbourne, Melbourne, VIC, AustraliaDepartment of Obstetric Medicine and Maternal Fetal Medicine, Royal Women’s Hospital, Melbourne, VIC, AustraliaDepartment of Obstetrics and Gynaecology, Epworth Healthcare, Melbourne, VIC, AustraliaDepartment of Infectious Diseases, Monash Health, Melbourne, VIC, AustraliaDepartment of Obstetrics and Gynaecology, Monash University, Melbourne, VIC, AustraliaDepartment of Infectious Diseases, Monash Health, Melbourne, VIC, AustraliaDepartment of Paediatrics, Telethon Kids, Perth, WA, AustraliaDepartment of Paediatrics, Telethon Kids, Perth, WA, AustraliaDepartment of Obstetrics and Gynaecology, Monash University, Melbourne, VIC, AustraliaDepartment of Paediatrics, Telethon Kids, Perth, WA, AustraliaMaternal immunisation, a low cost and high efficacy intervention is recommended for its pathogen specific protection. Evidence suggests that maternal immunisation has another significant impact: reduction of preterm birth (PTB), the single greatest cause of childhood morbidity and mortality globally. Our overarching question is: how does maternal immunisation modify the immune system in pregnant women and/or their newborn to reduce adverse pregnancy outcomes and enhance the newborn infant’s capacity to protect itself from infectious diseases during early childhood? To answer this question we are conducting a multi-site, prospective observational cohort study collecting maternal and infant biological samples at defined time points during pregnancy and post-partum from nulliparous women. We aim to enrol 400 women and determine the immune trajectory in pregnancy and the impact of maternal immunisation (including influenza, pertussis and/or COVID-19 vaccines) on this trajectory. The results are expected to identify areas that can be targeted for future intervention studies.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1212320/fullpregnancyvaccinationpreterm birthinfluenzapertussis |
| spellingShingle | Michelle L. Giles Michelle L. Giles Michelle L. Giles Stephen Cole Jessica O’Bryan Sushena Krishnaswamy Sushena Krishnaswamy Rym Ben-Othman Nelly Amenyogbe Mary-Ann Davey Tobias Kollmann The PRotective Effect of Maternal Immunisation on preTerm birth: characterising the Underlying mechanisms and Role in newborn immune function: the PREMITUR study protocol Frontiers in Immunology pregnancy vaccination preterm birth influenza pertussis |
| title | The PRotective Effect of Maternal Immunisation on preTerm birth: characterising the Underlying mechanisms and Role in newborn immune function: the PREMITUR study protocol |
| title_full | The PRotective Effect of Maternal Immunisation on preTerm birth: characterising the Underlying mechanisms and Role in newborn immune function: the PREMITUR study protocol |
| title_fullStr | The PRotective Effect of Maternal Immunisation on preTerm birth: characterising the Underlying mechanisms and Role in newborn immune function: the PREMITUR study protocol |
| title_full_unstemmed | The PRotective Effect of Maternal Immunisation on preTerm birth: characterising the Underlying mechanisms and Role in newborn immune function: the PREMITUR study protocol |
| title_short | The PRotective Effect of Maternal Immunisation on preTerm birth: characterising the Underlying mechanisms and Role in newborn immune function: the PREMITUR study protocol |
| title_sort | protective effect of maternal immunisation on preterm birth characterising the underlying mechanisms and role in newborn immune function the premitur study protocol |
| topic | pregnancy vaccination preterm birth influenza pertussis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1212320/full |
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