Contralateral axillary lymph node metastasis in breast cancer: An oligometastatic-like disease
Background: Contralateral axillary lymph node metastasis (CAM) is rare. It remains controversial whether CAM should be regarded as a regional or distant metastatic disease. Our study aims to investigate the accurate clinical orientation and management of CAM. Methods: Two hundred and ninety-nine fem...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Breast |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0960977623005659 |
| _version_ | 1797430092325978112 |
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| author | Qian Zhao Fan Yang Huai-liang Wu Miao Mo Yun-xiao Ling Guang-yu Liu |
| author_facet | Qian Zhao Fan Yang Huai-liang Wu Miao Mo Yun-xiao Ling Guang-yu Liu |
| author_sort | Qian Zhao |
| collection | DOAJ |
| description | Background: Contralateral axillary lymph node metastasis (CAM) is rare. It remains controversial whether CAM should be regarded as a regional or distant metastatic disease. Our study aims to investigate the accurate clinical orientation and management of CAM. Methods: Two hundred and ninety-nine female patients diagnosed with breast cancer from 2000 to 2014 and confirmed to develop CAM, oligometastasis (OM) or locoregional recurrence (LRR) at Fudan University Shanghai Cancer Center (FUSCC) were included in this study. Baseline information and survival outcomes were analyzed and compared among the three groups. Results: Patients with CAM exhibited similar overall survival (OS) and progression-free survival (PFS) to those with OM, but worse than those with LRR (HR: 0.47 [95 % CI: 0.27–0.85], p = 0.0097; HR:0.39 [95 % CI: 0.24–0.63], p < 0.0001, respectively). Considering the patients presented with CAM or OM as a whole, we found that local treatment combined with systemic treatment did not provide a superior survival benefit over systemic treatment alone. Conclusion: CAM was similar to an oligometastatic-like disease, and patients with these diseases may benefit from systemic treatment. Adding local treatment failed to significantly improve OS. |
| first_indexed | 2024-03-09T09:22:38Z |
| format | Article |
| id | doaj.art-ed2e116e0e1a47478e8d92e85ab8ab77 |
| institution | Directory Open Access Journal |
| issn | 1532-3080 |
| language | English |
| last_indexed | 2024-03-09T09:22:38Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Breast |
| spelling | doaj.art-ed2e116e0e1a47478e8d92e85ab8ab772023-12-02T06:58:49ZengElsevierBreast1532-30802023-12-0172103589Contralateral axillary lymph node metastasis in breast cancer: An oligometastatic-like diseaseQian Zhao0Fan Yang1Huai-liang Wu2Miao Mo3Yun-xiao Ling4Guang-yu Liu5Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People's Republic of ChinaDepartment of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People's Republic of ChinaDepartment of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People's Republic of ChinaClinical Statistics Center, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People's Republic of ChinaDepartment of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People's Republic of ChinaDepartment of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China; Corresponding author. Department of Breast Surgery, Fudan University Shanghai Cancer Center, 270 Dongan Road, Xuhui District, Shanghai, 200032, PR China.Background: Contralateral axillary lymph node metastasis (CAM) is rare. It remains controversial whether CAM should be regarded as a regional or distant metastatic disease. Our study aims to investigate the accurate clinical orientation and management of CAM. Methods: Two hundred and ninety-nine female patients diagnosed with breast cancer from 2000 to 2014 and confirmed to develop CAM, oligometastasis (OM) or locoregional recurrence (LRR) at Fudan University Shanghai Cancer Center (FUSCC) were included in this study. Baseline information and survival outcomes were analyzed and compared among the three groups. Results: Patients with CAM exhibited similar overall survival (OS) and progression-free survival (PFS) to those with OM, but worse than those with LRR (HR: 0.47 [95 % CI: 0.27–0.85], p = 0.0097; HR:0.39 [95 % CI: 0.24–0.63], p < 0.0001, respectively). Considering the patients presented with CAM or OM as a whole, we found that local treatment combined with systemic treatment did not provide a superior survival benefit over systemic treatment alone. Conclusion: CAM was similar to an oligometastatic-like disease, and patients with these diseases may benefit from systemic treatment. Adding local treatment failed to significantly improve OS.http://www.sciencedirect.com/science/article/pii/S0960977623005659Breast cancerContralateral axillary lymph node metastasisOligometastasisLocoregional recurrencePrognosis |
| spellingShingle | Qian Zhao Fan Yang Huai-liang Wu Miao Mo Yun-xiao Ling Guang-yu Liu Contralateral axillary lymph node metastasis in breast cancer: An oligometastatic-like disease Breast Breast cancer Contralateral axillary lymph node metastasis Oligometastasis Locoregional recurrence Prognosis |
| title | Contralateral axillary lymph node metastasis in breast cancer: An oligometastatic-like disease |
| title_full | Contralateral axillary lymph node metastasis in breast cancer: An oligometastatic-like disease |
| title_fullStr | Contralateral axillary lymph node metastasis in breast cancer: An oligometastatic-like disease |
| title_full_unstemmed | Contralateral axillary lymph node metastasis in breast cancer: An oligometastatic-like disease |
| title_short | Contralateral axillary lymph node metastasis in breast cancer: An oligometastatic-like disease |
| title_sort | contralateral axillary lymph node metastasis in breast cancer an oligometastatic like disease |
| topic | Breast cancer Contralateral axillary lymph node metastasis Oligometastasis Locoregional recurrence Prognosis |
| url | http://www.sciencedirect.com/science/article/pii/S0960977623005659 |
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