Gestational hypertension and risk of atopic diseases in offspring, a national-wide cohort study
IntroductionGestational hypertension can lead to complications, such as preeclampsia. Preeclampsia is one of leading causes of perinatal morbidity and mortality. Abnormal placentation, immune dysregulation, and maternal inflammatory response are possible etiologies. The burden of atopic diseases is...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2023.1283782/full |
| _version_ | 1827668878951448576 |
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| author | Chun-Ti Yang Ching-Heng Lin Ming-Chih Lin Ming-Chih Lin Ming-Chih Lin Ming-Chih Lin Ming-Chih Lin |
| author_facet | Chun-Ti Yang Ching-Heng Lin Ming-Chih Lin Ming-Chih Lin Ming-Chih Lin Ming-Chih Lin Ming-Chih Lin |
| author_sort | Chun-Ti Yang |
| collection | DOAJ |
| description | IntroductionGestational hypertension can lead to complications, such as preeclampsia. Preeclampsia is one of leading causes of perinatal morbidity and mortality. Abnormal placentation, immune dysregulation, and maternal inflammatory response are possible etiologies. The burden of atopic diseases is increasing worldwide. Prenatal exposure might play a role in the pathogenesis of these two diseases. The aim of this study was to evaluate the association between gestational hypertension and atopic diseases from a nationwide perspective.Material and methodsThe primary data were retrieved from Taiwan's National Health Insurance Research Database. The Maternal and Child Health Database was used to generate links between mothers and children. From 2004 to 2019, mothers with a diagnosis of gestational hypertension were identified as cases. The control groups were matched to the cases by maternal age, neonatal gender, date of birth, at a control-to-case ratio of 4:1. Each child was reviewed to confirm the diagnosis of atopic disease. Covariates including both maternal and neonatal factors were also collected.ResultsA total of 1,935,874 primiparas were enrolled in this study. After excluding 16,851 mothers with a history of hypertension, a total of 1,919,023 offspring were included in the study for the period 2004–2019. Gestational hypertension was associated with asthma (HR, 1.12, 95% CI, 1.02–1.23) and atopic dermatitis (HR, 1.10, 95% CI, 1.00–1.21) in offspring after controlling for cofactors. Nevertheless, gestational hypertension did not play an independent factor for allergic rhinitis (HR, 1.02, 95% CI, 0.95–1.10) or urticaria (HR, 1.02, 95% CI, 0.91–1.15).ConclusionMaternal gestational hypertension increases the cumulative risk for asthma and atopic dermatitis in offspring. |
| first_indexed | 2024-03-10T03:51:45Z |
| format | Article |
| id | doaj.art-ed2e2f973c46445fae5634df7db38d09 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-03-10T03:51:45Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-ed2e2f973c46445fae5634df7db38d092023-11-23T11:06:04ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602023-11-011110.3389/fped.2023.12837821283782Gestational hypertension and risk of atopic diseases in offspring, a national-wide cohort studyChun-Ti Yang0Ching-Heng Lin1Ming-Chih Lin2Ming-Chih Lin3Ming-Chih Lin4Ming-Chih Lin5Ming-Chih Lin6Children’s Medical Center, Taichung Veterans General Hospital, Taichung, TaiwanDepartment of Medical Research, Taichung Veterans General Hospital, Taichung, TaiwanChildren’s Medical Center, Taichung Veterans General Hospital, Taichung, TaiwanDepartment of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, TaiwanSchool of Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanDepartment of Food and Nutrition, Providence University, Taichung, TaiwanSchool of Medicine, Chung Shan Medical University, Taichung, TaiwanIntroductionGestational hypertension can lead to complications, such as preeclampsia. Preeclampsia is one of leading causes of perinatal morbidity and mortality. Abnormal placentation, immune dysregulation, and maternal inflammatory response are possible etiologies. The burden of atopic diseases is increasing worldwide. Prenatal exposure might play a role in the pathogenesis of these two diseases. The aim of this study was to evaluate the association between gestational hypertension and atopic diseases from a nationwide perspective.Material and methodsThe primary data were retrieved from Taiwan's National Health Insurance Research Database. The Maternal and Child Health Database was used to generate links between mothers and children. From 2004 to 2019, mothers with a diagnosis of gestational hypertension were identified as cases. The control groups were matched to the cases by maternal age, neonatal gender, date of birth, at a control-to-case ratio of 4:1. Each child was reviewed to confirm the diagnosis of atopic disease. Covariates including both maternal and neonatal factors were also collected.ResultsA total of 1,935,874 primiparas were enrolled in this study. After excluding 16,851 mothers with a history of hypertension, a total of 1,919,023 offspring were included in the study for the period 2004–2019. Gestational hypertension was associated with asthma (HR, 1.12, 95% CI, 1.02–1.23) and atopic dermatitis (HR, 1.10, 95% CI, 1.00–1.21) in offspring after controlling for cofactors. Nevertheless, gestational hypertension did not play an independent factor for allergic rhinitis (HR, 1.02, 95% CI, 0.95–1.10) or urticaria (HR, 1.02, 95% CI, 0.91–1.15).ConclusionMaternal gestational hypertension increases the cumulative risk for asthma and atopic dermatitis in offspring.https://www.frontiersin.org/articles/10.3389/fped.2023.1283782/fullgestational hypertensionasthmaatopic dermatitisallergic rhinitisurticaria |
| spellingShingle | Chun-Ti Yang Ching-Heng Lin Ming-Chih Lin Ming-Chih Lin Ming-Chih Lin Ming-Chih Lin Ming-Chih Lin Gestational hypertension and risk of atopic diseases in offspring, a national-wide cohort study Frontiers in Pediatrics gestational hypertension asthma atopic dermatitis allergic rhinitis urticaria |
| title | Gestational hypertension and risk of atopic diseases in offspring, a national-wide cohort study |
| title_full | Gestational hypertension and risk of atopic diseases in offspring, a national-wide cohort study |
| title_fullStr | Gestational hypertension and risk of atopic diseases in offspring, a national-wide cohort study |
| title_full_unstemmed | Gestational hypertension and risk of atopic diseases in offspring, a national-wide cohort study |
| title_short | Gestational hypertension and risk of atopic diseases in offspring, a national-wide cohort study |
| title_sort | gestational hypertension and risk of atopic diseases in offspring a national wide cohort study |
| topic | gestational hypertension asthma atopic dermatitis allergic rhinitis urticaria |
| url | https://www.frontiersin.org/articles/10.3389/fped.2023.1283782/full |
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