Enhancing Anti-G Antibody Induction by a Live Single-Cycle Prefusion F—Expressing RSV Vaccine Improves In Vitro and In Vivo Efficacy

Enhancing Anti-G Antibody Induction by a Live Single-Cycle Prefusion F—Expressing RSV Vaccine Improves In Vitro and In Vivo Efficacy

The human respiratory syncytial virus (RSV) is a major cause of severe respiratory tract disease, and a vaccine is not available. We previously reported a novel live vaccine expressing prefusion-stabilized fusion protein (preF) in place of the native F protein (RSV-preF<sup>ΔCT</sup>). A...

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Bibliographic Details
Main Authors: Pramila Lamichhane, Megolhubino Terhüja, Timothy A. Snider, Antonius G. P. Oomens
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Viruses
Subjects:
respiratory syncytial virus
RSV
vaccine
attachment protein
G protein
prefusion F
Online Access:https://www.mdpi.com/1999-4915/14/11/2474

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