Structural basis for recognition of transcriptional terminator structures by ProQ/FinO domain RNA chaperones
In this work, the authors determine the crystal structure of a ProQ/FinO RNA chaperone bound to its RNA target. This provides insight into how this family of bacterial proteins recognize transcriptional terminator structures.
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-11-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-34875-5 |
| _version_ | 1797984103767736320 |
|---|---|
| author | Hyeong Jin Kim Mazzen Black Ross A. Edwards Flora Peillard-Fiorente Rashmi Panigrahi David Klingler Reiner Eidelpes Ricarda Zeindl Shiyun Peng Jikun Su Ayat R. Omar Andrew M. MacMillan Christoph Kreutz Martin Tollinger Xavier Charpentier Laetitia Attaiech J. N. Mark Glover |
| author_facet | Hyeong Jin Kim Mazzen Black Ross A. Edwards Flora Peillard-Fiorente Rashmi Panigrahi David Klingler Reiner Eidelpes Ricarda Zeindl Shiyun Peng Jikun Su Ayat R. Omar Andrew M. MacMillan Christoph Kreutz Martin Tollinger Xavier Charpentier Laetitia Attaiech J. N. Mark Glover |
| author_sort | Hyeong Jin Kim |
| collection | DOAJ |
| description | In this work, the authors determine the crystal structure of a ProQ/FinO RNA chaperone bound to its RNA target. This provides insight into how this family of bacterial proteins recognize transcriptional terminator structures. |
| first_indexed | 2024-04-11T06:56:12Z |
| format | Article |
| id | doaj.art-ed2f8557c2fb4c6eb131771b7b1f7a50 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T06:56:12Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-ed2f8557c2fb4c6eb131771b7b1f7a502022-12-22T04:39:01ZengNature PortfolioNature Communications2041-17232022-11-0113111210.1038/s41467-022-34875-5Structural basis for recognition of transcriptional terminator structures by ProQ/FinO domain RNA chaperonesHyeong Jin Kim0Mazzen Black1Ross A. Edwards2Flora Peillard-Fiorente3Rashmi Panigrahi4David Klingler5Reiner Eidelpes6Ricarda Zeindl7Shiyun Peng8Jikun Su9Ayat R. Omar10Andrew M. MacMillan11Christoph Kreutz12Martin Tollinger13Xavier Charpentier14Laetitia Attaiech15J. N. Mark Glover16Department of Biochemistry, University of AlbertaDepartment of Biochemistry, University of AlbertaDepartment of Biochemistry, University of AlbertaCIRI, Centre International de Recherche en Infectiologie, Team “Horizontal gene transfer in bacterial pathogens”, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Université de LyonDepartment of Biochemistry, University of AlbertaInstitute of Organic Chemistry, Center for Molecular Biosciences Innsbruck (CMBI), University of InnsbruckInstitute of Organic Chemistry, Center for Molecular Biosciences Innsbruck (CMBI), University of InnsbruckInstitute of Organic Chemistry, Center for Molecular Biosciences Innsbruck (CMBI), University of InnsbruckDepartment of Biochemistry, University of AlbertaDepartment of Biochemistry, University of AlbertaDepartment of Biochemistry, University of AlbertaDepartment of Biochemistry, University of AlbertaInstitute of Organic Chemistry, Center for Molecular Biosciences Innsbruck (CMBI), University of InnsbruckInstitute of Organic Chemistry, Center for Molecular Biosciences Innsbruck (CMBI), University of InnsbruckCIRI, Centre International de Recherche en Infectiologie, Team “Horizontal gene transfer in bacterial pathogens”, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Université de LyonCIRI, Centre International de Recherche en Infectiologie, Team “Horizontal gene transfer in bacterial pathogens”, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Université de LyonDepartment of Biochemistry, University of AlbertaIn this work, the authors determine the crystal structure of a ProQ/FinO RNA chaperone bound to its RNA target. This provides insight into how this family of bacterial proteins recognize transcriptional terminator structures.https://doi.org/10.1038/s41467-022-34875-5 |
| spellingShingle | Hyeong Jin Kim Mazzen Black Ross A. Edwards Flora Peillard-Fiorente Rashmi Panigrahi David Klingler Reiner Eidelpes Ricarda Zeindl Shiyun Peng Jikun Su Ayat R. Omar Andrew M. MacMillan Christoph Kreutz Martin Tollinger Xavier Charpentier Laetitia Attaiech J. N. Mark Glover Structural basis for recognition of transcriptional terminator structures by ProQ/FinO domain RNA chaperones Nature Communications |
| title | Structural basis for recognition of transcriptional terminator structures by ProQ/FinO domain RNA chaperones |
| title_full | Structural basis for recognition of transcriptional terminator structures by ProQ/FinO domain RNA chaperones |
| title_fullStr | Structural basis for recognition of transcriptional terminator structures by ProQ/FinO domain RNA chaperones |
| title_full_unstemmed | Structural basis for recognition of transcriptional terminator structures by ProQ/FinO domain RNA chaperones |
| title_short | Structural basis for recognition of transcriptional terminator structures by ProQ/FinO domain RNA chaperones |
| title_sort | structural basis for recognition of transcriptional terminator structures by proq fino domain rna chaperones |
| url | https://doi.org/10.1038/s41467-022-34875-5 |
| work_keys_str_mv | AT hyeongjinkim structuralbasisforrecognitionoftranscriptionalterminatorstructuresbyproqfinodomainrnachaperones AT mazzenblack structuralbasisforrecognitionoftranscriptionalterminatorstructuresbyproqfinodomainrnachaperones AT rossaedwards structuralbasisforrecognitionoftranscriptionalterminatorstructuresbyproqfinodomainrnachaperones AT florapeillardfiorente structuralbasisforrecognitionoftranscriptionalterminatorstructuresbyproqfinodomainrnachaperones AT rashmipanigrahi structuralbasisforrecognitionoftranscriptionalterminatorstructuresbyproqfinodomainrnachaperones AT davidklingler structuralbasisforrecognitionoftranscriptionalterminatorstructuresbyproqfinodomainrnachaperones AT reinereidelpes structuralbasisforrecognitionoftranscriptionalterminatorstructuresbyproqfinodomainrnachaperones AT ricardazeindl structuralbasisforrecognitionoftranscriptionalterminatorstructuresbyproqfinodomainrnachaperones AT shiyunpeng structuralbasisforrecognitionoftranscriptionalterminatorstructuresbyproqfinodomainrnachaperones AT jikunsu structuralbasisforrecognitionoftranscriptionalterminatorstructuresbyproqfinodomainrnachaperones AT ayatromar structuralbasisforrecognitionoftranscriptionalterminatorstructuresbyproqfinodomainrnachaperones AT andrewmmacmillan structuralbasisforrecognitionoftranscriptionalterminatorstructuresbyproqfinodomainrnachaperones AT christophkreutz structuralbasisforrecognitionoftranscriptionalterminatorstructuresbyproqfinodomainrnachaperones AT martintollinger structuralbasisforrecognitionoftranscriptionalterminatorstructuresbyproqfinodomainrnachaperones AT xaviercharpentier structuralbasisforrecognitionoftranscriptionalterminatorstructuresbyproqfinodomainrnachaperones AT laetitiaattaiech structuralbasisforrecognitionoftranscriptionalterminatorstructuresbyproqfinodomainrnachaperones AT jnmarkglover structuralbasisforrecognitionoftranscriptionalterminatorstructuresbyproqfinodomainrnachaperones |