Silencing I2PP2A rescues tau pathologies and memory deficits through rescuing PP2A and inhibiting GSK-3β signaling in human tau transgenic mice
Increase of inhibitor-2 of protein phosphatase-2A (I2PP2A) is associated with PP2A inhibition and tau hyperphosphorylation in Alzheimer’s disease (AD). Down-regulating I2PP2A attenuated amyloidogenesis and improved the cognitive functions in transgenic mice expressing amyloid precursor protein (tg25...
Main Authors: | Yao eZhang, Rong-Hong eMa, Xia-Chun eLi, Jia-Yu eZhang, Hai-Rong eShi, Wei eWei, Dan-Ju eLuo, Qun eWang, Jian-Zhi eWang, Gong-Ping eLiu |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2014-06-01
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Series: | Frontiers in Aging Neuroscience |
Subjects: | |
Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00123/full |
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